Amyotrophic Lateral Sclerosis

About the Disease
Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, also known as guam disease, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 3 and frontotemporal dementia and/or amyotrophic lateral sclerosis 2, and has symptoms including tremor, bradykinesia and abnormality of extrapyramidal motor function. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 is TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Varenicline and Riluzole have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spinal cord and brain, and related phenotypes are muscle weakness and dementia

Common Targets
DYSF | PSEN1 | HTR1A | MAP3K12 | GBA1 | RBFOX1 | ZFPM1 | MLKL | SLC1A3 | TARDBP | EMC10 | CCNF | ROCK1 | G4233 | GARS1 | PLD1 | Kainate Receptor (GluR) (nonspecified subtype) | CARM1 | LOC105377329 | PTBP1 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | GABA(A) receptor | NOS1 | GAPDH | UMODL1 | ERLIN1 | VDR | NGFR | SARM1 | KCND3 | PRMT6 | KEAP1 | TAFA5 | Lipoxygenase (nonspecified subtype) | G4318 | GDF11 | TRPV4 | Carnitine O-Palmitoyltransferase 1 (CPT-1) (nonspecified subtype) | G3569 | SPG11 | GH1 | SIGMAR1 | Voltage-Gated Sodium Channel Complex | DRD4 | PDE8A | Gamma-Aminobutyric acid type B receptor | MAP2K7 | IFNB1 | G3630 | CHRM1 | LIMK1 | GRIN1 | HDAC8 | CFD | CDK13 | LOC102724192 | MAP3K5 | KCNQ4 | MELK | LCK | MGLL | BCR | DAO | SUSD2 | SPATS2 | T-Type Calcium Channel | ICAM1 | PRDM16 | KCNQ3 | Sodium channel (nonspecified subtype) | C9orf72 | CCNH | APLNR | CHGB | MTM1 | SCFD1 | PRMT8 | Rho GTPase (nonspecified subtype) | G7124 | PLD2 | KRT18P55 | PPP3R2 | CCDC102A | HTR2B | TRPC5 | NRG1 | IL13RA2 | AQP7 | ME1 | NCAM1 | CA1 | TRPV2 | GNG13 | LINC03021 | CDK5/p25 | ADORA2B | MN1 | NOS3 | EVA1A | CDK5 | NOL4L-DT | PSEN2 | IL1B | SRR | HDAC3 | MMP21 | G367 | CSNK1G2 | NR1H3 | STX8 | ADORA2A | ANKRD18B | MIR4300HG | IL-1 Receptor (nonspecified subtype) | DYRK1A | MMP12 | ZMAT4 | CASP8 | PPP3CC | NPHP4 | GPNMB | CELF1 | PPIB | ARPP21 | HNRNPA1 | MIR485 | G3480 | VAV2 | ANXA11 | PDE10A | MIR155 | NTRK1 | ZFYVE26 | CCKBR | CD14 | P3H3 | XDH | Neurotrophic Factor (nonspecified subtype) | Tyrosine Kinase (nonspecified subtype) | LIMK2 | TLR2 | G7422 | PLA2G4B | ITM2B | PPID | GSTA1 | SCN8A | cGMP-Dependent Protein Kinase (nonspecified subtype) | SOD2 | DPYSL3 | SHANK2 | CDNF | NTRK3 | Glutamate Transporter (nonspecified subtype) | PDE9A | GSK3B | CHRNA7 | alpha-Adrenoceptor (nonspecified subtype) | ABCG1 | BCHE | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | RET | ANKRD29 | beta-Secretase (nonspecified subtype) | MC2R | NLRC3 | TNNI2 | SORT1 | KCNK2 | MOBP | LOC101060106 | MYORG | G836 | RTN4 | Casein kinase I (nonspecified subtype) | Reverse transcriptase (Telomerase) | MMP2 | S1PR4 | CD38 | HSPA12B | HSF1 | NFATC2 | INSR | Opioid receptor (nonspecified subtype) | ERICH1 | PGAM5-KEAP1-NRF2 Complex | ATP7A | CHCHD10 | G7015 | MAP3K11 | GRIA2 | Gap junction Connexin ( (nonspecified subtype) | SMPD1 | FCGR3A | EIF4B | DNM1L | TESK1 | XPO1 | LSM7 | GPR3 | SEC23A | TGM2 | APOC3 | G4137 | TUBA4A | IRAK4 | TAF15 | Alcohol Dehydrogenase (nonspecified subtype) | MCF2L | KIF3B | SLC6A4 | TIA1 | Mitogen-Activated Protein Kinase (nonspecified subtype) | G7157 | UNC13A | HTR2A | SLC46A1 | NIPA1 | Nicotinic alpha4beta2 receptor | Chaperone (nonspecified subtype) | SPEM1 | SS18L1 | Nicotinic alpha3beta4 Receptor | HTRA3 | NF-kappaB (NFkB) | Skeletal muscle troponin | Death-associated protein kinase (nonspecified subtype) | FXN | SGK2 | ADRB1 | GRIN2A | LDLRAD1 | NINJ2 | PYY2 | HS3ST1 | S1PR3 | GRM7 | NEXMIF | Interleukin-12 (IL-12) | PDGFRA | TRAPPC9 | TLR9 | USP14 | PLXNA1 | GSTP1 | KLHL29 | JAK2 | PARP11 | MOB3B | TNKS2 | K(ATP) Channel (nonspecified subtype) | TMEM132D | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | SEMA5B | NMDA receptor | TSPO | PRMT1 | SLC12A5 | CHMP2B | PRSS3 | SLC1A6 | EIF2AK4 | FKBP5 | FAAH | TRPA1 | KCNK13 | FERMT2 | PTPRJ | DAD1 | PIKFYVE | BSCL2 | BBS7 | IGHMBP2 | KIF5A | G673 | MAP3K13 | MAP4K4 | HIC1 | KIT | PTK2B | TRHDE | CYP2R1 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | DHCR7 | VHL | AAK1 | PRF1 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | ADRB2 | DDR1 | BMP2K | MATR3 | ZBTB5 | SCN9A | SPIDR | TNNT3 | CASP2 | OSBPL2 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | E4F1 | ERBB4 | LOC105374187 | JAK1 | ATP8B3 | JAK3 | DERL1 | MAP4K1 | TREM2 | P4HB | SPTLC1 | ROCK2 | CLCN1 | GSTO2 | RBFOX3 | MMP13 | NLRP3 Inflammasome | DLG4 | CHIA | UGDH-AS1 | OPTN | HMG20B | PANX2 | LILRB3 | Proteasome Complex | ERVW-1 | KDM1A | FAM205A | MFN2 | G114548 | NOX3 | PINK1 | SPAST | ATP6V0E2 | PJVK | CDK1/Cyclin B | DHCR24 | CAPN1 | ALS2 | Complement Complex | Histone deacetylase (nonspecified subtype) | NADSYN1 | LARGE1 | H2BP1 | APOE | KCNQ1 | GRID1 | ABHD6 | Pyruvate dehydrogenase kinase (nonspecified subtype) | Transforming growth factor beta (nonspecified subtype) | CRBN | GAA | TNFRSF11A | SLC52A3 | FOLH1 | AFF2 | MAP2K2 | MEGF6 | C7 | Heat shock protein 70 (nonspecified subtype) | CHROMR | GLT8D1 | PON1 | CA2 | EPX | PLEKHG5 | APEX1 | SPG7 | LMNA | Janus Kinase (nonspecified subtype) | G7099 | UBAP2 | LYN | GC | VAPB | HTR6 | Dopamine receptor (nonspecified subtype) | ACVR1B | EPHA4 | PDE1B | PFN1 | HSPB1 | Poly [ADP-ribose] polymerase (nonspecified subtype) | MIF | HTR1B | LRRC4 | TGFB1 | KCNQ5 | BCL2L14 | TREM1 | EPOR | FAM167B | OGA | C3 | FBXO38 | S1PR5 | NPEPPS | TTC7A | CALB2 | SUN3 | PPP3CB | NADPH Oxidase Complex | HTR2C | RORB | STMN2 | PTPRN2 | APP | ADH7 | Cyclooxygenase (COX) (nonspecified subtype) | SYNE1 | NAMPT | DNAJB2 | Potassium Channels (nonspecified subtype) | VCP | FTO | GABRA5 | PPP3R1 | IL6R | TRPM2 | ARHGEF39 | TMEM97 | Nitric oxide synthase (NOS) (nonspecified subtype) | DCTN1 | PEPD | CLK1 | ACMSD | DPP6 | ANG | TRPM7 | STING1 | ABL1 | Peptidylprolyl Isomerase (nonspecified subtype) | AMDHD1 | MC4R | ALOX5 | FUS | SPHK1 | ZNF512B | XRCC1 | RECK | SSTR5 | G6774 | SLC1A1 | PRDM16-DT | NT5E | P2RX7 | ZBTB7A | MSTN | LRRC20 | GPR55 | C5AR1 | GLP1R | ZNF843 | SMPD3 | PLEKHA3 | ASIC1 | MMP8 | POU3F3 | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | ALB | KIFAP3 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | TRHR | NQO2 | ARL14EPL | NEFH | FYN | PAX8 | SIRT5 | CRISPLD2 | KRR1 | FGFR2 | GABRD | GSTZ1 | AKR1B10 | RUSC2 | SMN1 | MAOB | HTT | SETX | PLA2G7 | Gap Junction Protein (nonspecified subtype) | NADPH Oxidase (nonspecified subtype) | SQLE | VRK1 | GRHPR | RIPK1 | Arginase (nonspecified subtype) | ATXN1 | S1PR1 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | IRAK1 | EIF2AK3 | CDK1 | Rho kinase (ROCK) (nonspecified subtype) | SEMA3A | TGFBR2 | GRIN2B | MYCN | TRMT2A | HIF1A | GJD2 | RIPK3 | NR1D2 | SLC26A8 | AMP-activated protein kinase (AMPK) | STX1A | CAB39 | PPP1R9A | ANKRD20A19P | SLC43A1 | TNIP1 | ADAMTS2 | FIG4 | OPRM1 | PDGFRB | KIF24 | CSF1R | BTK | MMP14 | ARHGAP45 | WDR18 | PARK7 | MIR126 | CDK7/Cyclin H | CX3CR1 | PRKN | HDAC6 | NR4A2 | G2475 | G6647 | TLN1 | G4780 | SLC29A1 | MPO | CFAP410 | NTRK2 | SYF2 | STK39 | UBQLN2 | CSNK1D | SORL1 | G6714 | CDK12 | IL1RN | CDK7 | TBK1 | PTAFR | CDC42 | ERVK-6 | ABAT | DNAJC7 | KDM4B | PLEKHF1 | G8878 | HDAC2 | PPARGC1A | LGALS1 | CAMKK1 | CRACR2A | GRN | PRKG1 | Superoxide dismutase (SOD) (nonspecified subtype) | CNR2 | HPGDS | RAB39B | ALDH1B1 | ODC1 | TTBK1 | PRPH | PTGER2 | WASHC5 | Phosphodiesterase (nonspecified subtype) | RORC | MYRF | NGF | EXOC2 | ATXN2 | CASP6 | KCNQ2 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | SLC1A2 | ASTL | FOS | PON2 | HRH3 | HTR1D | Glutamate Receptor Ionotropic (nonspecified subtype) | STXBP1 | HTR7 | CYLD | SPAG8 | CDK6 | Protein Phosphatase 2B | LY96 | PIK3CA | LRP4 | MMP10 | L3MBTL1 | PRMT3 | MIR129-1 | HELZ2 | PPARA | Calcium channel (nonspecified subtype) | Glutamate Receptor Ionotropic AMPA Receptor | CD3 Complex (T Cell Receptor Complex) | DRD2 | PPIA | CDK2 | CDK4 | RNASEL | NEK1 | SELENOW | MTHFR | Na+/Ca2+ Exchanger (NCX) (nonspecified subtype) | ARHGAP22 | G1956 | RIGI | mu-Calpain (calpain 1) | KCNN2 | SNCA | Carbonic Anhydrase (nonspecified subtype) | TYK2 | SLC6A5 | YES1 | PDE7A | RIPK2 | APTX | LRRK2 | FGFR3 | ADAR | Monoamine oxidase (MAO) (nonspecified subtype) | Heat shock protein 90 (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | RIN1 | HFE | NOTCH3 | TRPM8 | MED9 | CTSD | PLCG2 | KAT2B | GPR35 | NR3C1 | CGAS | ATL1 | POLDIP3 | G142 | POLR1E | MFN1 | Eukaryotic translation initiation factor 2B | PPP5D1P | RAB29 | MAP2K4 | CSK | SREBF1 | PCSK1 | TNKS | GSK3A | KMO | GHSR | CNR1 | CYP51A1 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | C5 | TRPV1 | CDC7 | CASZ1 | TFG | CD40LG | SIRT2 | C19orf12 | Cyclin B (nonspecified subtype) | CEP112 | TCF7L1 | G5743 | MAOA | PTGES | Complement component 1q | GAREM2 | Tubulin | CENPV | BRD4 | GNE | PON3 | ZGRF1 | CYSLTR1 | GRM5 | MAP2K1 | ITPR2 | DDR2 | IL2RA | DNASE1 | UNC13B | G4851 | LINC02911 | HDAC1 | PTGS1 | AACS | ACHE | PPP1R15A | MED14 | SLC6A2 | FLCN | FKBP1A

Note: If you'd like to get a target analysis report for Amyotrophic Lateral Sclerosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Amyotrophic Lateral Sclerosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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