Tenosynovial Giant Cell Tumor

About the Disease
Pigmented Villonodular Synovitis, also known as localized pigmented villonodular synovitis, is related to villonodular synovitis and synovitis, and has symptoms including pain An important gene associated with Pigmented Villonodular Synovitis is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Granisetron and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testis and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
CCN1 | IFIT1B | H3-3B | SOGA3 | ASB7 | FANCE | CC2D1A | TNFSF11 | G4318 | OSGIN1 | ANKRD61 | TENM1 | FLT3 | MIDEAS | PFKFB4 | SESTD1 | IDH2 | FDPS | CBL | SLC45A1 | RUFY1 | CXCR2 | IKZF3 | CSF2 | DNAH7 | IGFBP4 | KMT2D | ZNF665 | KIT | ATN1 | SLC15A5 | MMP1 | LRRC3C | MAN2B1 | MYO3A | PCDHB6 | IKBKE | KIF26A | CSF1R | PDGFRB | ZNF687 | PPARG | ASXL1 | ZXDB | ZNF366 | H3-3A | MED13L

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