Calcium Pyrophosphate Deposition Disease

About the Disease
Chondrocalcinosis, also known as pseudogout, is related to familial calcium pyrophosphate deposition and gitelman syndrome, and has symptoms including joint stiffness An important gene associated with Chondrocalcinosis is CCAL1 (Chondrocalcinosis 1 (Calcium Pyrophosphate-Deposition Disease, Early Onset Osteoarthritis)), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and Inflammasomes. The drugs Prednisone and Povidone K30 have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and b cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Common Targets
TNFRSF11B | ALPL | HFE | ADAMTS5 | ENPP3 | MS4A1 | Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) (nonspecified subtype) | ENPP1 | ALPI | ENPP2

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