Papillon-Lefevre Syndrome

About the Disease
Papillon-Lefevre Syndrome, also known as papillon-lefèvre syndrome, is related to periodontitis and dermatophytosis. An important gene associated with Papillon-Lefevre Syndrome is CTSC (Cathepsin C), and among its related pathways/superpathways are Innate Immune System and Extracellular matrix organization. The drugs Acetaminophen and Valaciclovir have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and brain, and related phenotypes are palmoplantar keratoderma and abnormal fingernail morphology

Common Targets
HLA-DRB1 | CTSC

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