5-oxoprolinase Deficiency

About the Disease
Glutathione Synthetase Deficiency, also known as pyroglutamic aciduria, is related to hemolytic anemia and bilirubin metabolic disorder, and has symptoms including abdominal pain, diarrhea and vomiting. An important gene associated with Glutathione Synthetase Deficiency is GSS (Glutathione Synthetase), and among its related pathways/superpathways are Metabolism and Metapathway biotransformation Phase I and II. Affiliated tissues include brain, neutrophil and bone marrow, and related phenotypes are hemolytic anemia and abnormality of immune system physiology

Common Targets
OPLAH

Note: If you'd like to get a target analysis report for 5-oxoprolinase Deficiency, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of 5-oxoprolinase Deficiency at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Spinocerebellar Ataxia Type 13 | Kabuki Syndrome | Fascioliasis | Myocardial Infarction | Supravalvular Aortic Stenosis | Hemolytic Uremic Syndrome, Atypical | Lymphedema-distichiasis Syndrome | Congenital Myopathy | Zimmermann-Laband Syndrome | Anal Fissure | Mountain Sickness | VACTERL Association | Ophthalmoplegia | Angiosarcoma Of The Breast | Gastroenteritis, Eosinophilic | Schizotypal Personality Disorder | Primary Hyperoxaluria Type 1 | Joubert Syndrome | Exotropia | Schindler Disease | Primary Ovarian Insufficiency | Diffuse Palmoplantar Keratoderma | Cancer, Prostate | Metabolic Syndrome | Hypospadias | Superficial Spreading Melanoma | Neuroendocrine Cancer | Keratoacanthoma | Leishmaniasis, Cutaneous | Hypolipoproteinemia | Sclerosteosis | Spinocerebellar Ataxia Type 27 | Hepatorenal Syndrome | Hypertensive Nephropathy | Wilson's Disease | Metatropic Dysplasia | Lichen Sclerosus | IgA Deficiency | Glycogen Storage Disease Type 5 | Polycythemia Vera | Malonyl-CoA Decarboxylase Deficiency | Marshall-Smith Syndrome | Pyelonephritis | Sarcosinemia | Graft-versus-host Disease | DICER1 Syndrome | Kaposi Sarcoma | Neurocutaneous Melanocytosis | Non-Hodgkin Lymphoma | Porphyria | Phosphoglycerate Dehydrogenase Deficiency | Conn Syndrome | Membranous Nephropathy | Pancreatitis | Cysticercosis | Vasculitis | Cholangitis | Lymphoma | Abetalipoproteinemia | Barrett Esophagus | Multiple System Atrophy | WAGR Syndrome | Ureteropelvic Junction Obstruction | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Infectious Diarrhea | Currarino Syndrome | Evans Syndrome | Hemorrhoids | ADNP Syndrome | Sarcoma, Alveolar Soft Part | Ganglioglioma | Xeroderma Pigmentosum Variant Type | Ichthyosis Hystrix, Curth-Macklin Type | Dysplastic Nevus | Congenital Diaphragmatic Hernia | Hypogammaglobulinemia | Orthostatic Intolerance | Asthma | Pontocerebellar Hypoplasia Type 7 | Autoimmune Hemolytic Anemia | IMAGe Syndrome | Hereditary Elliptocytosis | Acne Vulgaris | Episodic Ataxia Type 2 | Liebenberg Syndrome | Dystrophy, Cone-rod | Dyggve-Melchior-Clausen Disease | Congenital Heart Block | Pearson Syndrome | Nevus | Twin-to-twin Transfusion Syndrome | Spondylolisthesis | Early Infantile Epileptic Encephalopathy 4 | Hyperandrogenemia | Interstitial Lung Diseases | Mosaic Variegated Aneuploidy Syndrome 2 | Takotsubo Cardiomyopathy | Chylomicron Retention Disease | Trichomegaly | Cataract | Corticobasal Syndrome | Glomerulonephritis, Membranoproliferative | Sitosterolemia | Hypopigmentation | Incontinentia Pigmenti | Systemic Mastocytosis | DiGeorge Syndrome | Spinocerebellar Ataxia Type 12 | Vitiligo | Pfeiffer Syndrome | Cerebellar Ataxia, Cayman Type | Occipital Neuralgia | Arthritis, Psoriatic | Inborn Errors Of Metabolism | Usher Syndrome | Glanzmann Thrombasthenia | Veno-occlusive Disease | Snyder-Robinson Syndrome | Pleural Tuberculosis | Hypercalciuria | Osteogenesis Imperfecta Type V | Mitochondrial Encephalomyopathy | Trachoma | Rosacea | Neovascular Glaucoma | 3-methylglutaconic Aciduria | Enlarged Vestibular Aqueduct | Hepatic Veno-occlusive Disease | Prolymphocytic Leukemia | Chromosome 17q21.31 Deletion Syndrome | Restrictive Dermopathy | Myositis, Focal | Cockayne Syndrome | Sezary Syndrome | PASLI Disease | Granuloma Annulare | Apert Syndrome | Lipid Storage Myopathy | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Hyperostosis | Glioblastoma Multiforme | Neurocysticercosis | Malaria | Dermatitis | Dowling-Degos Disease | Hyperprolactinemia | Cabezas Syndrome | Charcot-Marie-Tooth Disease Type 4E | Hamartoma | Congenital Stromal Corneal Dystrophy | Myelodysplasia | Cutaneous Mastocytosis | Myoclonic Atonic Epilepsy | Muir-Torre Syndrome | Trichotillomania | Von Hippel-Lindau Disease | Adult Polyglucosan Body Disease | Ichthyosis Bullosa Of Siemens | Rhizomelic Chondrodysplasia Punctata | Anorchia | Leukocyte Adhesion Deficiency | Rothmund-Thomson Syndrome | Heterotopic Ossification | Pulmonary Veno-occlusive Disease | Dysgerminoma | Trimethylaminuria | Polymyositis | Impulse Control Disorder | Myotonia | Fibromuscular Dysplasia | Amelogenesis Imperfecta | Stuttering | Peutz-Jeghers Syndrome | Peyronie's Disease | Optic Atrophy 2 | Pleomorphic Xanthoastrocytoma | Mitochondrial DNA Depletion Syndrome 13 | DRESS Syndrome | Thrombocytopenia | Multiple Sclerosis | Anorexia Nervosa | Tibial Muscular Dystrophy | Microcephaly, Seizures, And Developmental Delay | Goiter, Nodular | Cole-Carpenter Syndrome | Otitis Externa | Achromatopsia | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | ICF Syndrome | Cohen Syndrome | Spinocerebellar Ataxia Type 1 | Bruck Syndrome | Cerebrovascular Disorders | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Crisponi Syndrome | Premature Ejaculation | Headache | Autosomal Recessive Bestrophinopathy | Papillon-Lefevre Syndrome | HANAC Syndrome | Turner's Syndrome | Tetanus | Schistosomiasis Mansoni | Transcobalamin Deficiency | Pituitary Disorders | Sickle Cell Anemia | Large Granular Lymphocytic Leukemia | Sarcoma | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Overactive Bladder | Craniopharyngioma | Osteogenesis Imperfecta Type III | Swine Influenza | Hyperparathyroidism | Gynecomastia | Aarskog-Scott Syndrome | Aldosterone Synthase Deficiency | Primary Erythromelalgia | Chediak-Higashi Syndrome | Atelosteogenesis Type 2 | Urticaria | Carotid Artery Disease | Anemia | Nephrosclerosis | Acquired Partial Lipodystrophy | Cutaneous T-cell Lymphoma | Central Core Disease | Dystonia-parkinsonism, X-linked | Anencephaly | Peritonitis | Acute Coronary Syndrome | Megalencephaly | Fundus Albipunctatus | Atrioventricular Septal Defect | N-acetylglutamate Synthase Deficiency | Glycogen Storage Disease Type 1b | Enhanced S-cone Syndrome | Rift Valley Fever | Osteomalacia | Congenital Poikiloderma | Glomerulonephritis | Klippel-Feil Syndrome | Trismus-pseudocamptodactyly Syndrome | Speech Disorders | Cholelithiasis | Hypodontia | Lennox-Gastaut Syndrome | Parkinsonism | Walker-Warburg Syndrome | Duane Retraction Syndrome | Spondylo-ocular Syndrome | Eiken Syndrome | Pericarditis | Alpha-thalassemia Myelodysplasia Syndrome | Vogt-Koyanagi-Harada Syndrome | Urea Cycle Disorder | Hypohidrotic Ectodermal Dysplasia, X-linked | Progressive Myoclonic Epilepsy | Alagille Syndrome | Sleep Apnea, Obstructive | Adenoid Cystic Carcinoma | Leiomyoma | Congenital Afibrinogenemia | Aneurysm, Thoracic Aortic | Spinocerebellar Ataxia Type 8 | Christianson Syndrome | Stickler Syndrome | Polyarteritis Nodosa | Meningeal Melanocytoma | Ollier Disease | Acne | KBG Syndrome | Retinal Dystrophy | Cryptosporidiosis | Porphyria, Acute Intermittent | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Camptocormia | Cancer, Brain | Acrodysostosis | Familial Male-limited Precocious Puberty | Ophthalmia, Sympathetic | Generalized Epilepsy And Paroxysmal Dyskinesia | Chronic Mucocutaneous Candidiasis | Spinocerebellar Ataxia | Gingivitis | Chronic Granulomatous Disease | Cyst | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Inflammatory Myopathy | Insulin Resistance | Osteoglophonic Dysplasia | Diabetes Insipidus | Krabbe Disease | Papilloma | Cold-induced Sweating Syndrome | Hyperuricemia | Chronic Kidney Disease | Diverticulitis | Thyrotoxic Periodic Paralysis | Blue Nevus | Hypoproteinemia, Hypercatabolic | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Pachyonychia Congenita | Polyomavirus Nephropathy | Greig Cephalopolysyndactyly Syndrome | Orotic Aciduria | Anti-glomerular Basement Membrane Disease | Focal Dermal Hypoplasia | Takenouchi-Kosaki Syndrome | Transthyretin-related Amyloidosis | Bacterial Meningitis | Microphthalmia, Syndromic 7 | Pulmonary Vein Stenosis | Polycystic Kidney, Autosomal Dominant | Measles | Nephrotic Syndrome | Charcot-Marie-Tooth Disease, Type 6 | Depression | Anosmia, Congenital | Silver-Russell Syndrome | Silicosis | Congenital Hereditary Endothelial Dystrophy Type I | Loeys-Dietz Syndrome | Marinesco-Sjogren Syndrome | Osteogenesis Imperfecta Type IV | Encephalopathy, Hepatic | Muckle-Wells Syndrome | Charcot-Marie-Tooth Disease, Type 2A | Cranial Nerve Disease | Asperger Syndrome | Diabetes Insipidus, Neurogenic | Camurati-Engelmann Disease | Mixed Connective Tissue Disease | Congenital Aniridia | Phenylketonuria II | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Babesiosis | Acute Lung Injury | Congenital Heart Defects | Agammaglobulinemia | Syphilis | Thyroid Dyshormonogenesis | Scleroderma | Esophageal Carcinoma | Familial Retinal Arterial Macroaneurysm | Opisthorchiasis | Bone Marrow Necrosis | Smith-Magenis Syndrome | Sporadic Inclusion Body Myositis | Granular Corneal Dystrophy Type 1 | Mucolipidosis | Celiac Disease | Chordoma | Haim-Munk Syndrome | Rotor Syndrome | Traboulsi Syndrome | Birk-Barel Syndrome | Parapsoriasis | Ectodermal Dysplasia | Lattice Corneal Dystrophy | Neurofibromatosis | Spinocerebellar Ataxia Type 23 | Epidermolytic Palmoplantar Keratoderma | Anorectal Fistula | Lissencephaly 2 | Herpes Simplex Dermatitis | Impetigo | Melanoma, Uveal | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Pancreatitis, Chronic | Lymphangioleiomyomatosis | Neuromuscular Disorders | Agnathia-Otocephaly Complex | Primary Biliary Cholangitis | Idiopathic Pulmonary Fibrosis | Noonan Syndrome | Vascular Cognitive Impairment | Specific Granule Deficiency | Early Infantile Epileptic Encephalopathy 13 | Okihiro Syndrome | CDKL5 Deficiency Disorder | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Fibromyalgia | Aphasia | Cholestasis | Skin Fragility-woolly Hair Syndrome | Cancer, Lung | Familial Isolated Hyperparathyroidism | Roberts Syndrome | Congenital Bile Acid Synthesis Defect | Premenstrual Syndrome | Long QT Syndrome Type 3 | Hypertension, Pulmonary | Hereditary Xerocytosis | Cerebellofaciodental Syndrome | Neurofibroma | Histoplasmosis | Carcinoma, Transitional Cell | Hyperferritinemia-cataract Syndrome | Charcot-Marie-Tooth Disease Type 2D