Sezary Syndrome

About the Disease
Sezary's Disease, also known as sezary syndrome, is related to primary cutaneous t-cell non-hodgkin lymphoma and lymphoma, hodgkin, classic, and has symptoms including pruritus An important gene associated with Sezary's Disease is BCL10 (BCL10 Immune Signaling Adaptor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Denileukin diftitox and Fosaprepitant have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone marrow, and related phenotypes are dry skin and neoplasm of the skin

Common Targets
G999 | CCR10 | GPR25 | TRIM3 | LRRC7 | OR5M3 | G0S2 | RAPGEF6 | MED23 | FBXW5 | ADGRB3 | CLPX | VIL1 | ECRG4 | UMODL1 | ELP2 | ANKRD50 | RUNX3 | WFDC8 | SEMA5A | RGS7 | ZEB1 | SYT17 | GNB2 | RPS6KA2 | FFAR1 | PDXK | ADAMTSL4 | SEC16B | RBM19 | IFNGR1 | ZNF682 | VN1R2 | ZNF75A | GNAL | CTNNA3 | KCNK15 | CRTC2 | FAT4 | KRTAP9-6 | ZNF572 | HEATR6 | GABRG2 | OR11L1 | CACNA1S | MUC16 | TMPRSS13 | HDAC3 | ASB5 | PLCZ1 | SLC28A1 | NLGN3 | HHAT | NRG1 | NCAM1 | PKHD1L1 | ME1 | CNOT1 | MLPH | DPP4 | TOM1L1 | GABRB2 | MAGEC1 | JAKMIP1 | BMX | CARD11 | LOC100506422 | CCR4 | SLCO4C1 | MYH10 | CACNA1G | TANC1 | TNPO2 | G3605 | PCDH18 | IFI44L | ANO4 | COL8A2 | AQP4 | PTCH1 | CLSTN2 | LSM14B | OBSCN | PDE8B | TAAR5 | ADAMTS8 | SLCO2B1 | PRR30 | COL4A6 | ZFYVE26 | TSPOAP1 | DDX52 | TMEM132B | GLI3 | MYO3B | AGRN | FPR1 | TAF1L | PCDH19 | DROSHA | PCDH20 | CCDC83 | PRDM10 | DIP2B | IVL | TMEM266 | SLC18A3 | PCSK5 | ASXL3 | EIF2A | CAMTA1 | GATA6 | IRX6 | ZNF644 | Interferon-gamma Receptor | MMP2 | ABCA8 | CPT1A | SNX16 | G7157 | PIGA | PCDHA1 | RSL24D1 | TNS4 | RHEB | ZNF749 | CACNB2 | SUN1 | TSSK1B | PRR21 | TSPAN4 | NBR1 | TPO | TMC6 | LIN7A | TET2 | PLIN3 | DYNC1I1 | PLS3 | RYR2 | POM121L2 | HNRNPH1 | PABIR3 | CKAP4 | GART | KRTAP5-1 | DYNC1I2 | HSPD1 | TTC28 | LEAP2 | FAT3 | COL9A1 | SPACA7 | EFCAB6 | GRTP1 | TEX14 | SHROOM3 | FAM186A | APOH | CERKL | RNF145 | DNMT3B | IQGAP1 | TMPO | UNC13A | DNAH5 | MAGEB18 | IGFN1 | GRIN2A | FAM83C | EVC | NRG3 | ZFHX4 | SLC6A15 | SIRPA | CENPF | JUNB | ASPH | C1orf87 | PHLDB1 | ZNF471 | ERI2 | SPATA3 | PFKFB2 | ILDR1 | GRM7 | ZSCAN5B | GCOM1 | CHRM3 | ANKRD13D | ADD1 | EML6 | GFRA1 | TENM1 | DYTN | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | STC1 | PXDN | DTD2 | AMIGO2 | SLC22A2 | MME | MOB3B | IQSEC1 | IL2 | EPPK1 | KCNK10 | TMEM132D | OLIG3 | LMOD2 | NOS2 | IGDCC4 | WDR17 | ANO3 | TANC2 | SEMA5B | SENP5 | DCHS1 | TET1 | TAS1R2 | ADGRV1 | KRT8 | ADAM23 | PCDHGB2 | HLA-DQA2 | CDC27 | SCNN1G | IGHMBP2 | LILRA4 | CCDC113 | CD52 | MKI67 | PMEL | TNFAIP3 | OBSL1 | LINGO1 | HSPB6 | WSB1 | KCNJ3 | OR10G4 | FGGY | ELMO1 | CACNG7 | ID4 | C6orf118 | TAS1R1 | GBP3 | STPG2 | TFAP2A | PSME1 | PRRC2B | WNK2 | PAOX | CCAR1 | CYP4F22 | ABCC9 | BCO1 | Histone deacetylase (nonspecified subtype) | TRIM60 | CRBN | NOX3 | MAP3K19 | IGSF1 | OR10AD1 | G920 | PCLO | LONP1 | SKIDA1 | DPP10 | TGFB2 | CMYA5 | JAKMIP3 | P3H2 | DRAM1 | CPEB3 | ZNF804A | ALDH1A1 | OSGIN2 | CREB3L1 | YLPM1 | VCPIP1 | CD70 | ANO2 | UNC13C | ZBTB41 | ASS1 | FGF10 | CD7 | PPP1R1C | LYN | UNC79 | GALNT17 | HMCN1 | NANOGNB | ZNF222 | LTBP1 | MARK1 | DNAH2 | MTMR9 | PHC2 | ITLN1 | IER5 | MAML2 | LRRC17 | OR2W3 | OR52I2 | UBP1 | G5133 | ADCY8 | ATP2A2 | CDH7 | AMPD2 | IL18RAP | SNCAIP | OR2T8 | SPTBN1 | TOP2A | MMRN1 | PLCG1 | CD3E | UGGT2 | COL10A1 | PROM1 | NIN | NEK4 | USH2A | OR2L13 | KDM2B | ATXN7L3B | IMPG1 | MUC2 | RASL10A | FAS | ZNF423 | HUWE1 | SLC9C2 | DDX43 | DNAH7 | WDR59 | PAM | APPBP2 | GABRQ | LAMA2 | LTN1 | CD47 | LRRC30 | OTOG | PTPRN2 | LMNTD1 | DSPP | EEF1A2 | TH | CCDC8 | SAMHD1 | RIMS1 | FEM1B | LAMA1 | TMC5 | ARID1A | RXYLT1 | ACACB | VWC2 | GRM1 | GJC2 | CNTN1 | TDRD6 | PREX2 | MAOB | GPLD1 | GUCY2C | CRYBG3 | FAM209B | DOCK3 | FAM227A | TAL1 | ARL6 | CLMN | PCDHGA1 | DSC1 | CRISPLD2 | SCAPER | REG3A | POLR2A | CCDC172 | NDP | USP30 | LRP1B | G29126 | GALNT18 | LRP2 | MAPRE3 | PSD2 | KCNK5 | TRPS1 | NRAP | SPIRE1 | DCDC1 | CLCN5 | COL11A1 | CDHR2 | OR2A12 | GPR158 | ATXN1 | MDGA2 | MUC21 | NUP88 | ATR | SLC15A5 | GMPS | SEMA3A | SLCO2A1 | PLPPR1 | PTN | ZC2HC1A | PLEKHN1 | SCHIP1 | DOCK8 | WDR87 | TECPR2 | SLCO3A1 | PTK7 | ACTA1 | HDAC6 | UNC80 | PPP2R3A | OSMR | CORIN | ABCB11 | GPR83 | TRA2B | MROH7 | OTOF | PTCHD1 | UCHL3 | CACNA1E | ARL14EP | TWIST1 | SLF1 | SCAI | FEZ1 | USP9X | MIPOL1 | ZNF416 | TSPYL6 | EPRS1 | NPAT | HDAC2 | MAGEB10 | RHOA | BTBD9 | ACSM4 | COL6A3 | KCNU1 | CCDC175 | HCN1 | DPYD | RNF122 | SLC22A17 | ABCC3 | BMP5 | WNT16 | STON2 | DMD | DDAH2 | NEXN | ARMC5 | USH1C | QRICH2 | CDK5RAP3 | ANGPTL5 | HTR3D | STARD9 | ARMC12 | SALL3 | ATXN2 | DIABLO | STAT5B | CSMD2 | PLCH1 | RELN | RAG2 | RAP1B | COL4A4 | TLR3 | MLLT10 | UBE2E3 | PTGR3 | PID1 | SYTL5 | ZNF711 | CXCL16 | GNMT | GRIN3A | OR8U1 | MTUS2 | PDE3A | CC2D2A | PLEKHM3 | ENPP5 | CCDC168 | COL21A1 | EEA1 | SYT3 | P2RX6 | ARHGEF28 | GALR1 | CYP2C19 | SLC7A8 | TRUB2 | DIDO1 | NR3C2 | MYO5B | ATP1A2 | ITPR1 | LAMA4 | ADGRL3 | DOP1A | PLPP3 | RIPK2 | LAMC3 | COL22A1 | MYH8 | ZNF160 | ZNF831 | CNTNAP1 | GOLGA3 | alpha-Mannosidase (nonspecified subtype) | DNAH9 | LRRIQ1 | NEBL | MAP2K3 | APBB2 | SLC7A14 | EMD | LSG1 | NRXN3 | FMN2 | NES | RPS6KA1 | DNMT3A | AK5 | GOLGA4 | HSP90B1 | KIAA1107 | ARHGAP32 | SLN | LAMA5 | EFNB2 | G7124 | EPHA6 | PCDHA12 | HDAC1 | DCLK3 | STC2 | CCDC149 | NCOR1 | LINGO2 | TREML2 | ADAM29 | ABCA13 | CACNA2D1 | CDC7 | SYTL2 | DMRTB1 | TLR5 | KRTAP13-1 | PDZD2 | ST8SIA2 | HTR1A | C10orf90 | CSMD3 | COL12A1 | ZGRF1 | XIRP2 | CMTM2 | ANKUB1 | PLCB4 | ZFHX2 | PTPRR | TNFRSF1B | TRPC4 | NELL2 | OAS1 | CDH26 | KIR3DL2 | MPPED1 | LLCFC1 | SH3TC2 | MUC17 | OR4K1 | CHST15 | CRYBG1 | KRTAP5-5 | OR5AN1 | SENP3

Note: If you'd like to get a target analysis report for Sezary Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Sezary Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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