Diabetic Neuropathy

About the Disease
Diabetic Neuropathy, also known as diabetic neuropathies, is related to microvascular complications of diabetes 3 and diabetic polyneuropathy, and has symptoms including neuralgia and sciatica. An important gene associated with Diabetic Neuropathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and CREB Pathway. The drugs Histamine and Cetirizine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and dorsal root ganglion, and related phenotypes are no effect and no effect

Common Targets
Alpha-2 Adrenergic receptors (nonspecified subtype) | SLC6A2 | PTGS1 | AGT | HTR1A | ACHE | ROCK1 | TYR | CACNA2D2 | G4233 | TAFA5 | HMGCR | GABA(A) receptor | VDR | G23411 | CHRM4 | LPAR1 | FFAR1 | GRIK1 | G3569 | Voltage-Gated Sodium Channel Complex | G3630 | SIGMAR1 | CHRM1 | IL4R | MGLL | T-Type Calcium Channel | NFATC1 | Sodium channel (nonspecified subtype) | SCN3A | NOS3 | ALOX12 | CCR4 | HMOX2 | G7124 | CACNA1G | ADORA2A | IL1B | HSD11B1 | IL-1 Receptor (nonspecified subtype) | CCR2 | DPP4 | XDH | NTRK1 | NEDD4L | ND1 | Neurotrophic Factor (nonspecified subtype) | G7422 | PPID | CSF3R | AKR1B1 | SOD2 | CYTB | PTPN1 | FLT3 | AVPR2 | CHRNA7 | BCHE | TXNIP | N-Type Calcium Channel | RET | Reverse transcriptase (Telomerase) | KHK | HPGD | IL-4 receptor | G7015 | MASP2 | OPRD1 | TGFA | IRAK4 | PDE5A | MIR3138 | HTR2A | Nicotinic alpha4beta2 receptor | SLC6A4 | Nicotinic alpha3beta4 Receptor | AMP-activated protein kinase alpha2beta1gamma1 | ADORA3 | OPRL1 | IAPP | PTGER4 | AMP-activated protein kinase alpha1beta1gamma1 | NF-kappaB (NFkB) | CHRNA9 | GLO1 | CHRM3 | TNKS2 | AGTR1 | MME | TSPO | NMDA receptor | FAAH | 15-Lipoxygenase (nonspecified subtype) | TRPA1 | C3AR1 | AAK1 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | Heme Oxygenase (HO) (nonspecified subtype) | IL-6 receptor | SCN9A | CTNNB1 | JAK3 | PLXDC2 | NLRP3 Inflammasome | NOX3 | L-Type calcium channel (nonspecified subtype) | STS | G114548 | CCR5 | Complement Complex | MIR146A | ADIPOR1 | GHR | PRKCB | FOLH1 | CHUK | APOE | GAA | Heat shock protein 70 (nonspecified subtype) | TRPV3 | TACR1 | EDN1 | IL4 | Poly [ADP-ribose] polymerase (nonspecified subtype) | G7099 | BDKRB1 | SLC5A1 | NADPH Oxidase Complex | Gastric H+/K+-ATPase | G596 | APP | Cannabinoid receptor (nonspecified subtype) | TMEM97 | AGTR2 | IL13 | P2RX7 | ADIPOR2 | GLP1R | ASIC1 | SCN5A | NPR1 | APOL1 | HPSE | SIRT5 | SLC6A3 | F2R | HMOX1 | SERPINB7 | NADPH Oxidase (nonspecified subtype) | MAOB | Angiotensin receptor (AT) (nonspecified subtype) | S1PR1 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | Soluble guanylyl cyclase | G2069 | Rho kinase (ROCK) (nonspecified subtype) | ACE | GJD2 | AMP-activated protein kinase (AMPK) | DEFB1 | GRIN2B | OPRM1 | Nicotinic alpha9alpha10 Receptor | CHRM2 | ATP8 | ND5 | ANPEP | CHRNB2 | G6647 | HDAC6 | RHOA | G4780 | AOC3 | HDAC2 | IL1RN | CNR2 | Segment polarity protein dishevelled homolog (nonspecified subtype) | MIR499A | NGF | TRPC1 | ALOX15 | LHFPL3 | MIR128-1 | OPRK1 | IL22RA1 | HRH3 | CYBA | CAT | PPARG | Glutathione peroxidase (nonspecified subtype) | SLC5A2 | Innate Repair Receptor (IRR) | PPARA | AVPR1A | SCN10A | Carbonic Anhydrase (nonspecified subtype) | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | G1956 | NR3C2 | MTHFR | G5243 | Heat shock protein 90 (nonspecified subtype) | CACNA1H | TRPM8 | L-type voltage-dependent calcium channel complex | G142 | CACNA1B | TNKS | GHSR | CNR1 | COMT | TRPV1 | ZSCAN20 | GSR | CACNA2D1 | PICK1 | PTGES | MAOA | CSF3 | EPHX2 | G5743 | IKBKB | BRD4 | GRM5

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