Infantile Neuroaxonal Dystrophy

About the Disease
Neurodegeneration with Brain Iron Accumulation 2a, also known as infantile neuroaxonal dystrophy, is related to dementia, lewy body and parkinson disease 3, autosomal dominant, and has symptoms including ataxia, seizures and abnormal pyramidal signs. An important gene associated with Neurodegeneration with Brain Iron Accumulation 2a is PLA2G6 (Phospholipase A2 Group VI), and among its related pathways/superpathways are Metabolism and Glycerophospholipid biosynthesis. The drugs Desipramine and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and skin, and related phenotypes are developmental regression and cerebellar atrophy

Common Targets
GPR18 | METTL21C | PLA2G6 | NALCN | TFG | INSL6

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