Split Hand-foot Malformation

About the Disease
Split Hand-Foot Malformation, also known as ectrodactyly, is related to split-hand/foot malformation 1 and split-hand/foot malformation with long bone deficiency 1. An important gene associated with Split Hand-Foot Malformation is LEF1 (Lymphoid Enhancer Binding Factor 1), and among its related pathways/superpathways is Validated transcriptional targets of deltaNp63 isoforms. Affiliated tissues include bone, bone marrow and heart, and related phenotype is limbs/digits/tail.

Common Targets
UBA2 | HOXD10 | WNT10B | HOXD11 | MAP3K20 | HOXD12 | FGFR1 | TP63 | EPS15L1 | BHLHA9 | POLL | C2CD3 | DLX5 | CDH3 | DLX6 | FRAS1 | PORCN | ROR2 | HOXD1 | EVX2 | LRP6 | HOXD3

Note: If you'd like to get a target analysis report for Split Hand-foot Malformation, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Split Hand-foot Malformation at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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