Cholestasis

About the Disease
Cholestasis, also known as obstruction of bile duct, is related to cholestasis, intrahepatic, of pregnancy 3 and cholestasis, benign recurrent intrahepatic, 2, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Cholestasis is USP53 (Ubiquitin Specific Peptidase 53), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Lactulose and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and kidney, and related phenotypes are no effect and no effect

Common Targets
TGFB1 | GPBAR1 | PDE4B | Ribonucleoside-diphosphate reductase | CYP7A1 | NEK8 | PPARA | ABCC12 | MPV17 | PNPLA3 | CES2 | ANO1 | ABCB4 | CNR1 | PPARG | KIF12 | TJP1 | ATP8B1 | USP53 | G7124 | GABA(A) receptor | TWNK | HLA-A | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | AKR1D1 | NR1I2 | PPARD | G9429 | G836 | VPS33B | JAG1 | NR1H4 | SLC10A1 | ESRRA | POLG | ATP7B | MIR27A | HSD17B13 | Caspase (nonspecified subtype) | SLC25A13 | DCDC2 | SLC10A2 | TALDO1 | CFTR | NOTCH2 | UGT1A1 | HSD3B7 | NLRP3 Inflammasome | ABCC1 | PNLIP | ABCB11 | NPC1 | G114548 | MAOB | HNF1B | MYO5B | NF-kappaB (NFkB) | RORC | TJP2

Note: If you'd like to get a target analysis report for Cholestasis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Cholestasis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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