Orthostatic Hypotension

About the Disease
Pure Autonomic Failure, also known as orthostatic hypotension, is related to multiple system atrophy 1 and dementia, lewy body. An important gene associated with Pure Autonomic Failure is DBH (Dopamine Beta-Hydroxylase), and among its related pathways/superpathways are Neuroscience and superpathway of tryptophan utilization. The drugs Droxidopa and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, heart and brain, and related phenotypes are orthostatic hypotension and anhidrosis

Common Targets
ADRA1A | COMT | SLC6A2 | DBH | SLC6A4 | CYB561 | GRIN2B | DDC

Note: If you'd like to get a target analysis report for Orthostatic Hypotension, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Orthostatic Hypotension at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Gardner Syndrome | Postpartum Depression | Hereditary Sensory Neuropathy Type 1 | Neuromyotonia | Retinal Detachment | Auriculocondylar Syndrome | Pterygium | Left Ventricular Noncompaction | Inflammatory Joint Disease | Salla Disease | Progressive Myoclonic Epilepsy | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Spinocerebellar Ataxia Type 20 | Stroke, Ischemic | Sotos Syndrome | Leishmaniasis, Visceral | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Megaloblastic Anemia | Parkinson's Disease | Idiopathic Multicentric Castleman Disease | Proctitis | Fibrosis | Chondrodysplasia Punctata | Cocaine-Related Disorders | Pseudo-pseudohypoparathyroidism | Ichthyosis | Pycnodysostosis | Sickle Cell Disease | Waardenburg Syndrome Type 4A | Leiomyosarcoma | Cri-du-chat Syndrome | Familial Male-limited Precocious Puberty | Schuurs-Hoeijmakers Syndrome | Cerebrovascular Disorders | Hennekam Lymphangiectasia-lymphedema Syndrome | Behcet's Disease | Histoplasmosis | Neurofibromatosis-Noonan Syndrome | Optic Neuropathy | Vitreoretinal Degeneration, Snowflake Type | Tendinopathy | Neuroectodermal Tumors, Primitive | Adams-Oliver Syndrome | Autoimmune Hemolytic Anemia | Ectopia Lentis, Isolated, Autosomal Recessive | Cornelia De Lange Syndrome | Systemic Mastocytosis | Hairy Cell Leukemia | Adrenoleukodystrophy, X-linked | Von Willebrand Disease | Carotid Artery Disease | Pleural Tuberculosis | Gerodermia Osteodysplastica | Congenital Torticollis | Heimler Syndrome | Menetrier Disease | Myoclonus | Hypercalcemia | Duane Retraction Syndrome | Multicentric Carpotarsal Osteolysis Syndrome | Craniofrontonasal Syndrome | Optic Atrophy 2 | Hodgkin Lymphoma | Metatropic Dysplasia | Peroxisomal Disorder | Vitamin A Deficiency | Hypoparathyroidism | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Infertility | 3-methylglutaconic Aciduria | Dysferlinopathy | Glycogen Storage Disease | Asthma, Exercise-induced | Malnutrition | DEND Syndrome | Cutaneous T-cell Lymphoma | Cold Agglutinin Disease | Renal Tubular Acidosis | Carbamoyl Phosphate Synthetase I Deficiency | Spinocerebellar Ataxia Type 14 | Pericarditis | Wolman Disease | Periodic Limb Movement Disorder | Hemangioblastoma | Pseudohypoaldosteronism | Hepatopulmonary Syndrome | Progressive Familial Intrahepatic Cholestasis | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Renal Tubular Dysgenesis | Rhizomelic Chondrodysplasia Punctata | Stevens-Johnson Syndrome | Mevalonate Kinase Deficiency | Granular Corneal Dystrophy | Congenital Myopathy | MIRAGE Syndrome | Familial Hypertrophic Cardiomyopathy | Stickler Syndrome | Intellectual Disability, Autosomal Dominant 5 | Abetalipoproteinemia | Pachyonychia Congenita | Pyruvate Decarboxylase Deficiency | Sarcomatoid Carcinoma Of The Lung | Loeys-Dietz Syndrome Type 4 | Liver Failure, Acute Infantile | Epidermolysis Bullosa Simplex With Mottled Pigmentation | C3 Glomerulopathy | Familial Thoracic Aortic Aneurysm | Sialidosis | GAPO Syndrome | Endometritis | Gestational Trophoblastic Disease | X-linked Acrogigantism | Progressive Familial Intrahepatic Cholestasis Type 2 | Poretti-Boltshauser Syndrome | Charcot-Marie-Tooth Disease, Type 2 | Cryptococcal Meningitis | Obesity, Morbid | Paracoccidioidomycosis | Hypertension | Endometrial Hyperplasia | Anodontia | Goiter, Nodular | Tangier Disease | Dengue Shock Syndrome | Diffuse Palmoplantar Keratoderma | Paroxysmal Kinesigenic Dyskinesia | 3-M Syndrome | Renal Hypouricemia | Encephalopathy, Hepatic | CHARGE Syndrome | Non-proliferative Diabetic Retinopathy | B-cell Chronic Lymphocytic Leukemia | Marfan Syndrome | Congenital Heart Block | Meningioma | Reticular Dysgenesis | Mosaic Variegated Aneuploidy Syndrome 2 | Glycogen Storage Disease Type 5 | Familial Glucocorticoid Deficiency | Spinocerebellar Ataxia Type 27 | Vitelliform Macular Dystrophy | 3C Syndrome | Hereditary Neuropathy With Liability To Pressure Palsies | Silver-Russell Syndrome | Arthritis, Gouty | Fontaine Progeroid Syndrome | Chromosome 8q21.11 Deletion Syndrome | Rheumatic Heart Disease | Chitayat Syndrome | Usher Syndrome Type III | Trismus-pseudocamptodactyly Syndrome | Hypogammaglobulinemia | Eosinophilic Asthma | Schizophrenia, Paranoid | Galloway-Mowat Syndrome | Spinocerebellar Ataxia Type 21 | Atopy | Peyronie's Disease | Hepatoblastoma | Stargardt Disease | Lassa Fever | Lamellar Ichthyosis | Papilloma | Papillon-Lefevre Syndrome | Meleda Disease | Androgen Insensitivity | Episodic Ataxia Type 2 | Spinocerebellar Ataxia Type 7 | Goiter | Pitt-Hopkins Syndrome | Huntington's Disease | Ophthalmia, Sympathetic | Japanese Encephalitis | Lipodystrophy | Bronchiolitis | Cerebral Cavernous Malformations | Hyperoxaluria | Inborn Errors Of Metabolism | Primary Hyperoxaluria | Neuropathy | Spinocerebellar Ataxia Type 12 | Prediabetes | Scleroderma, Diffuse | Metabolic Diseases | Nemaline Myopathy 10 | ICF Syndrome | Primary Erythromelalgia | Tietze Syndrome | Medulloblastoma | Adrenomyeloneuropathy | Lipid Storage Myopathy | Epilepsy | L-2-Hydroxyglutaric Aciduria | Anorexia Nervosa | Myosin Storage Myopathy | Primary Progressive Aphasia | Ichthyosis, X-linked | Early Infantile Epileptic Encephalopathy 28 | Eccrine Porocarcinoma | SAPHO Syndrome | Gastroschisis | Spinocerebellar Ataxia Type 1 | Hereditary Folate Malabsorption | Uremia | Hermansky-Pudlak Syndrome | Tularemia | Adenoid Cystic Carcinoma | Charcot-Marie-Tooth Disease Type 2E | Kallmann Syndrome | Pregnancy, Ectopic | Choroiditis | Hereditary Xerocytosis | Osteogenesis Imperfecta Type I | Charcot-Marie-Tooth Disease, Type 1A | Coenzyme Q10 Deficiency | Ureteropelvic Junction Obstruction | Retinal Vasculitis | Asthma | DiGeorge Syndrome | Obsessive-compulsive Disorder | Optic Nerve Diseases | Delirium | Cholesteryl Ester Storage Disease | Porphyria | Blue Rubber Bleb Nevus Syndrome | Cole-Carpenter Syndrome | Intermittent Explosive Disorder | Osteogenesis Imperfecta Type VI | Alveolar Capillary Dysplasia | Familial Hemiplegic Migraine | Sclerosteosis | Ehlers-Danlos Syndrome | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Bipolar Disorder | Myoclonic Epilepsy With Ragged Red Fibers | Fuchs Dystrophy | TARP Syndrome | Familial Cerebral Amyloid Angiopathy | HANAC Syndrome | Non-Hodgkin Lymphoma | Cirrhosis | Smith-Kingsmore Syndrome | Syndactyly | Oculocutaneous Albinism Type 1 | Klinefelter Syndrome | Perry Syndrome | Hypermetropia | Anosmia, Congenital | Vitamin K Deficiency | Benign Familial Infantile Seizures | Bacterial Meningitis | Poikiloderma With Neutropenia | Bainbridge-Ropers Syndrome | Weill-Marchesani Syndrome | Thrombosis | Familial Episodic Pain Syndrome | Dominant Optic Atrophy | Amish Infantile Epilepsy Syndrome | Pilomatrix Carcinoma | Hypersensitivity Pneumonitis | Pulmonary Alveolar Microlithiasis | Asphyxia Neonatorum | IMAGe Syndrome | Hypereosinophilic Syndrome | Hyperparathyroidism-jaw Tumor Syndrome | Spinocerebellar Ataxia | Periventricular Nodular Heterotopia | Macrophage Activation Syndrome | Acute Coronary Syndrome | McKusick Type Metaphyseal Chondrodysplasia | Pemphigus | Branchiootorenal Syndrome | X-linked Charcot-Marie-Tooth Disease | Multisystemic Smooth Muscle Dysfunction Syndrome | Addison Disease | Hydrops Fetalis | Senior-Loken Syndrome | IgA Deficiency | Thymoma, Malignant | Okihiro Syndrome | H Syndrome | Spinocerebellar Ataxia Type 13 | Exfoliative Dermatitis | Chanarin-Dorfman Syndrome | Cardiospondylocarpofacial Syndrome | Bartter Syndrome | Bare Lymphocyte Syndrome | Pancytopenia | Alazami Syndrome | Kabuki Syndrome | Thalassemia, Beta | Contact Dermatitis | Scapuloperoneal Myopathy, X-linked Dominant | Congenital Adrenal Hyperplasia 1 | 3-methylglutaconic Aciduria Type IV | Genee-Wiedemann Syndrome | Chiari Malformation Type I | Arthritis, Reactive | Gilbert Syndrome | Keratoconus | Supravalvular Aortic Stenosis | Treacher Collins Syndrome | Pontocerebellar Hypoplasia | Subacute Sclerosing Panencephalitis | Familial Partial Lipodystrophy | Kearns-Sayre Syndrome | REM Sleep Behavior Disorder | Tyrosinemia Type 1 | Cystinuria | Acute Myeloid Leukemia | Moyamoya Disease | Urticaria | Papulopustular Rosacea | Hyperinsulinism-hyperammonemia Syndrome | Acquired Partial Lipodystrophy | Ataxia-ocular Apraxia 2 | Dermatofibrosarcoma | Gingivitis | Chronic Myeloid Leukemia | Dyskeratosis Congenita | Erythematotelangiectatic Rosacea | GM2-gangliosidosis AB Variant | D-2-Hydroxyglutaric Aciduria | Hereditary Mixed Polyposis Syndrome | Sleep Disorder | Epiphyseal Chondrodysplasia, Miura Type | Glioma | Gynecomastia | Myofibromatosis | Hypobetalipoproteinemias | Scapuloperoneal Spinal Muscular Atrophy | Microtia | Connective Tissue Disorders | Tendinitis | Pulmonary Alveolar Proteinosis | Retinitis | Extramammary Paget's Disease | Aceruloplasminemia | Premature Ejaculation | Low Phospholipid Associated Cholelithiasis | Periventricular Leukomalacia | Tyrosinemia | Bloom Syndrome | Compartment Syndrome | Thin Basement Membrane Disease | Disseminated Superficial Actinic Porokeratosis | Phenylketonuria | Zollinger-Ellison Syndrome | Encephalopathy, Ethylmalonic | Hydrolethalus Syndrome | Schnitzler Syndrome | Multiple Hamartoma Syndrome | Pyloric Stenosis, Infantile Hypertrophic | Tonsillitis | Yellow Fever | Congenital Tufting Enteropathy | Glycogen Storage Disease Type 9 | Meningococcal Infections | Angiosarcoma Of The Breast | Hypersensitivity | Renal Hypomagnesemia 3 | Martsolf Syndrome | Lichen Sclerosus | Microcephalic Primordial Dwarfism | Craniosynostosis | Light Chain Amyloidosis | Hemolytic Anemia | Hepatitis, Autoimmune | Macular Corneal Dystrophy | Acute Chest Syndrome | Congenital Lipoid Adrenal Hyperplasia | Acute Leukemia | Progressive Encephalopathy-optic Atrophy Syndrome | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Cerebrotendinous Xanthomatosis | Inflammatory Myopathy | Epidermal Nevus Syndrome | Stuttering | Muir-Torre Syndrome | Gerstmann-Straussler-Scheinker Syndrome | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Ectrodactyly | Hypolipoproteinemia | Cervical Dystonia | Neuroendocrine Cancer | Varices | Parkinson Disease 6, Autosomal Recessive Early-onset | Sialidosis Type I | Sorsby Fundus Dystrophy | Osteoporosis | Paraganglioma, Carotid Body | Subcortical Band Heterotopia | Blomstrand Osteochondrodysplasia | Dysfibrinogenemia | Dengue Hemorrhagic Fever | Combined Pituitary Hormone Deficiency | Disseminated Intravascular Coagulation | Familial Digital Arthropathy-brachydactyly | Hypospadias | Primary Familial Brain Calcification