Hypotension, Orthostatic

About the Disease
Pure Autonomic Failure, also known as orthostatic hypotension, is related to multiple system atrophy 1 and dementia, lewy body. An important gene associated with Pure Autonomic Failure is DBH (Dopamine Beta-Hydroxylase), and among its related pathways/superpathways are Neuroscience and superpathway of tryptophan utilization. The drugs Droxidopa and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, heart and brain, and related phenotypes are orthostatic hypotension and anhidrosis

Common Targets
ADRA1A | COMT | SLC6A2 | DBH | SLC6A4 | CYB561 | GRIN2B | DDC

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