Primary Familial Brain Calcification

About the Disease
Basal Ganglia Calcification, Idiopathic, 1, also known as primary familial brain calcification, is related to basal ganglia calcification and parkinsonism, and has symptoms including athetosis, cerebellar ataxia and muscle rigidity. An important gene associated with Basal Ganglia Calcification, Idiopathic, 1 is SLC20A2 (Solute Carrier Family 20 Member 2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Development EGFR signaling via small GTPases. Affiliated tissues include brain, cortex and caudate nucleus, and related phenotypes are cerebral calcification and hepatomegaly

Common Targets
MYORG | SLC20A2 | JAM2

Note: If you'd like to get a target analysis report for Primary Familial Brain Calcification, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Primary Familial Brain Calcification at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Pemphigus Vulgaris | Aplasia Cutis Congenita | Pleural Tuberculosis | Common Variable Immunodeficiency | Craniopharyngioma | Pierre Robin Syndrome | Sturge-Weber Syndrome | Harlequin Ichthyosis | Coloboma | Acute Motor Axonal Neuropathy | Neurotoxicity | Pleomorphic Xanthoastrocytoma | Scleroderma, Diffuse | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Porphyria, Variegate | Adenoma, Villous | Malignant Peripheral Nerve Sheath Tumor | Sialidosis | Dentinogenesis Imperfecta | Sarcoidosis, Pulmonary | Dermatomyositis | Myelitis | Primary Cutaneous Amyloidosis | Silver-Russell Syndrome | Episodic Ataxia Type 2 | Tenosynovial Giant Cell Tumor | Hepatitis, Alcoholic | Supravalvular Aortic Stenosis | Keratoconjunctivitis | Low Phospholipid Associated Cholelithiasis | Marfan Syndrome | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Twin-to-twin Transfusion Syndrome | Esotropia | Heterotaxy | Camptocormia | Hermansky-Pudlak Syndrome | Emery-Dreifuss Muscular Dystrophy | Peyronie's Disease | Chediak-Higashi Syndrome | Trichuriasis | Acromegaly | Kashin-Beck Disease | Hydrolethalus Syndrome | Stiff-man Syndrome | Acrodermatitis Enteropathica | Congenital Aniridia | Neuroleptic Malignant Syndrome | Hemochromatosis | Hemangioma | Hereditary Hemorrhagic Telangiectasia Type 2 | Amelogenesis Imperfecta | Vitamin A Deficiency | Arthropathy | L-2-Hydroxyglutaric Aciduria | Cryptorchidism | Progressive Familial Intrahepatic Cholestasis Type 3 | Analgesia | Melanoma, Uveal | Methylmalonic Aciduria And Homocystinuria, CblC Type | Obsessive-compulsive Disorder | Pituitary Stalk Interruption Syndrome | Mitochondrial Disease | Diarrhea | Chronic Lymphocytic Leukemia | Uremic Pruritus | Hepatorenal Syndrome | Anxiety Disorders | Congenital Dyserythropoietic Anemia | Uveitis, Anterior | Kidney Stones | Urethritis | Carcinoid Syndrome | Kernicterus | Hyperinsulinemia | Osmotic Demyelination Syndrome | Small Lymphocytic Lymphoma | Long QT Syndrome Type 3 | Neuromyelitis Optica | Neurofibroma | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | DRESS Syndrome | Cutaneous T-cell Lymphoma | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Barakat Syndrome | Retinopathy, Diabetic | Barrett Esophagus | Neurofibrosarcoma | Cervicitis | Diabetes Insipidus | C3 Glomerulopathy | Neuromuscular Disorders | Hemochromatosis Type 2 | Periventricular Nodular Heterotopia | Chronic Periodontitis | Angelman Syndrome | Colitis | Varices | Spondylometaphyseal Dysplasia | Thrombasthenia | Acute Chest Syndrome | Systemic Lupus Erythematosus | Mountain Sickness | Anencephaly | Combined Deficiency Of Factor V And Factor VIII | Left Ventricular Noncompaction | Dysmorphophobia | Autism | Blepharospasm | Diffuse Intrinsic Pontine Glioma | Heavy Chain Disease | Erectile Dysfunction | Malaria | Ornithine Transcarbamylase Deficiency | Chorea | Schwartz-Jampel-Aberfeld Syndrome | Antithrombin III Deficiency | Cholangiocarcinoma | Periodic Limb Movement Disorder | Tylosis With Esophageal Cancer | Tracheal Disorders | Glioblastoma Multiforme | Geleophysic Dysplasia | Carney-Stratakis Syndrome | Meckel-Gruber Syndrome | Leukocyte Adhesion Deficiency Type 1 | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Cat Eye Syndrome | Encephalocele | Myoclonus | Nail-Patella Syndrome | Choriocarcinoma | Bone Marrow Necrosis | Spinocerebellar Ataxia Type 2 | Fuchs Dystrophy | Seborrheic Dermatitis | Multiple Sulfatase Deficiency | Growth Hormone Excess | Hyperlipidemia Type V | Vitamin D Deficiency | Presbyopia | Incontinentia Pigmenti | Epidermolysis Bullosa Simplex, Generalized | Orotic Aciduria | Aceruloplasminemia | Takotsubo Cardiomyopathy | Aneurysm, Abdominal Aortic | Acute Lung Injury | Maternally Inherited Diabetes And Deafness | Chondroma | Trichotillomania | Asthma | Cornelia De Lange Syndrome | Astrocytoma | Infertility, Male | Orthostatic Intolerance | Acute Coronary Syndrome | Carcinoma, Signet Ring Cell | ACTH-independent Macronodular Adrenal Hyperplasia | Iron Overload | Charcot-Marie-Tooth Disease Type 3 | Papillorenal Syndrome | Bruck Syndrome | Malnutrition | Hypermethioninemia | Renal-hepatic-pancreatic Dysplasia | Hypersomnia | Rubinstein-Taybi Syndrome | Proximal Symphalangism | Stromal Corneal Dystrophy | Rickets | Nicotine Addiction | Bicuspid Aortic Valve | Cryopyrin-associated Periodic Syndromes | Neurodermatitis | Norrie Disease | Trimethylaminuria | Noonan Syndrome-like Disorder With Loose Anagen Hair | Nicolaides-Baraitser Syndrome | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Kabuki Syndrome 2 | Vici Syndrome | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Chordoma | Acute Kidney Injury | Steel Syndrome | Mitochondrial Myopathy | Smith-Magenis Syndrome | Osteomyelitis | Hepatoblastoma | Primary Aldosteronism | Empyema | Protein S Deficiency | Blepharophimosis Syndrome | Tricho-hepato-enteric Syndrome | Multiple System Atrophy | Hypotonia-cystinuria Syndrome | Hepatitis, Chronic | Congenital Sodium Diarrhea | Alpha-thalassemia Myelodysplasia Syndrome | Pachyonychia Congenita | Hyperlipidemia | Lung Diseases | Glioma | Lathosterolosis | Frank-ter Haar Syndrome | Netherton Syndrome | Hereditary Folate Malabsorption | Glanzmann Thrombasthenia | Thyroid Hormone Resistance | Hairy Cell Leukemia | Cousin Syndrome | Dominant Optic Atrophy | 3-M Syndrome | Tuberculosis | Dysferlinopathy | Cerebral Amyloid Angiopathy | Hypertensive Retinopathy | Blastoma, Pleuropulmonary | 3C Syndrome | Glycogen Storage Disease Type 3 | Thromboembolism | Osteoporosis | Pre-eclampsia | ADNP Syndrome | Dental Caries | Medulloblastoma | Sjogren Syndrome | Wolcott-Rallison Syndrome | Pierpont Syndrome | Distal Spinal Muscular Atrophy | Constipation | Herpes Simplex Dermatitis | Carcinoid Tumor | Gangliosidosis, GM1 | Richter's Syndrome | Polycythemia | Lymphoproliferative Disease, X-linked | Erythropoietic Protoporphyria | COACH Syndrome | Aldosteronism | Antley-Bixler Syndrome | Encephalopathy, Ethylmalonic | Lattice Corneal Dystrophy | Coffin-Lowry Syndrome | Temporal Lobe Epilepsy | Trachoma | Cholesteryl Ester Storage Disease | Pulmonary Stenosis | Eating Disorder | Acrodysostosis | Glycogen Storage Disease Type 0, Muscle | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Corneal Dystrophy And Perceptive Deafness | Goiter | Hyperkalemic Periodic Paralysis | Pseudomyxoma Peritonei | GAPO Syndrome | Fibronectin Glomerulopathy | Long QT Syndrome Type 2 | Demyelinating Diseases | Psoriasis | Scleritis | Glutaric Aciduria Type 3 | Epilepsy Of Infancy With Migrating Focal Seizures | Chiari Malformation Type I | Blepharoconjunctivitis | Thyroid Dyshormonogenesis | B-cell Prolymphocytic Leukemia | Myositis | Spinocerebellar Ataxia Type 31 | Cushing Syndrome | Ileitis | Hyperthyroidism | Sarcoma, Endometrial Stromal | Chromosome 8q21.11 Deletion Syndrome | Hypocalcemia | FG Syndrome | Pulmonary Alveolar Microlithiasis | Beta-Propeller Protein-associated Neurodegeneration | Fragile X Syndrome | Ameloblastic Carcinoma | Larsen Syndrome | Lymphedema-distichiasis Syndrome | Tardive Dyskinesia | Amyotrophic Lateral Sclerosis, Juvenile | Cohen Syndrome | Beckwith-Wiedemann Syndrome | Alexander Disease | Thrombophilia | Leigh Syndrome | Progressive Osseous Heteroplasia | IgA Deficiency | Microphthalmia | Cataract | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Pyoderma Gangrenosum | Raynaud Phenomenon | Tetanus | Bronchitis | Progressive Familial Intrahepatic Cholestasis | Facioscapulohumeral Muscular Dystrophy Type 2 | Stevens-Johnson Syndrome | Silicosis | Osteogenesis Imperfecta Type II | Nephroblastoma | Glycogen Storage Disease Type 0 | PASLI Disease | Acute Leukemia | Roberts Syndrome | Dyggve-Melchior-Clausen Disease | Spastic Paraplegia Type 7 | Generalized Epilepsy With Febrile Seizures Plus | Arthritis | Veno-occlusive Disease | Major Depression | Recurrent Respiratory Papillomatosis | Neuroendocrine Cancer | Enhanced S-cone Syndrome | Bernard-Soulier Syndrome | 3-methylglutaconic Aciduria Type I | Periodontitis | Mucolipidosis | Chronic Mucocutaneous Candidiasis | Congenital Muscular Dystrophy | Endocarditis | McKusick Type Metaphyseal Chondrodysplasia | Cancer, Colon | Pulmonary Veno-occlusive Disease | Hypobetalipoproteinemias | Fibrodysplasia Ossificans Progressiva | Bloom Syndrome | Adenosine Deaminase 2 Deficiency | Hypoproteinemia, Hypercatabolic | Iron Metabolism Disorders | Pigment Dispersion Syndrome | Lymphoma | Bardet-Biedl Syndrome | Ovarian Hyperstimulation Syndrome | Congenital Poikiloderma | Osteoarthritis | Seizures-scoliosis-macrocephaly Syndrome | Encephalopathy, Hepatic | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Lymphangiomatosis | Urofacial Syndrome | WAGR Syndrome | Hypersensitivity Pneumonitis | Cluster Headache | Partington Syndrome | Spermatocele | Paroxysmal Kinesigenic Dyskinesia | Mucormycosis | Lipid Storage Diseases | Autosomal Recessive Bestrophinopathy | Limb Girdle Muscular Dystrophy | Language Disorders | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Neonatal Progeroid Syndrome | Cancer, Breast | Prolactinoma | Central Core Disease | Werner's Syndrome | Eclampsia | Nutrition Disorders | Agranulocytosis | Alazami Syndrome | Uterine Leiomyoma | Clouston Hidrotic Ectodermal Dysplasia | Cone Dystrophy | Erythromelalgia | Split Hand-foot Malformation | Congenital Dyserythropoietic Anemia Type 1 | Insulinoma | Lymphedema | Hereditary Elliptocytosis | Hereditary Pyropoikilocytosis | Rheumatoid Arthritis | Nail Disorder, Nonsyndromic Congenital | Chronic Granulomatous Disease, X-linked | Blastomycosis | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Dystonia | Chordoid Glioma | Polydactyly | Pemphigoid | Miyoshi Myopathy | Carney Triad | Charcot-Marie-Tooth Disease Axonal Type 2N | Toxoplasmosis | Early Infantile Epileptic Encephalopathy 28 | Arthritis, Reactive | Tonsillitis | Exocrine Pancreatic Insufficiency | Niemann-Pick Disease | Congenital Fiber-type Disproportion Myopathy | Liver Diseases | Hypertriglyceridemia | Usher Syndrome Type IIC | Batten Disease