Heterotaxy

About the Disease
Visceral Heterotaxy, also known as situs ambiguus, is related to situs inversus and right atrial isomerism. An important gene associated with Visceral Heterotaxy is CFAP53 (Cilia And Flagella Associated Protein 53), and among its related pathways/superpathways are Mesodermal commitment pathway and Signaling by NODAL. The drug Kava has been mentioned in the context of this disorder. Affiliated tissues include heart, spleen and liver, and related phenotypes are nervous system and growth/size/body region

Common Targets
BCL9L | SESN1 | CCDC103 | MMP21 | FOXI2 | DNAH5 | CFAP53 | DNAH6 | DNAH11 | PKD1L1 | BCOR | CFTR | SPIRE1 | RPGR | ZIC3 | PCSK6 | NODAL | LEFTY2 | DNAH9 | CRELD1

Note: If you'd like to get a target analysis report for Heterotaxy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Heterotaxy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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