Birt-Hogg-Dube Syndrome

About the Disease
Birt-Hogg-Dube Syndrome, also known as fibrofolliculomas with trichodiscomas and acrochordons, is related to pneumothorax, primary spontaneous and renal oncocytoma. An important gene associated with Birt-Hogg-Dube Syndrome is FLCN (Folliculin), and among its related pathways/superpathways are Signal Transduction and Viral mRNA Translation. The drugs Miconazole and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and lung, and related phenotypes are emphysema and papule

Common Targets
PRDM10 | Lactate Dehydrogenase (LDH) | NRAS | FLCN

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