Sjogren Syndrome

About the Disease
Sjogren Syndrome, also known as sjogren's syndrome, is related to mononeuritis multiplex and aplasia of lacrimal and salivary glands, and has symptoms including dryness of eye, eye manifestations and back pain. An important gene associated with Sjogren Syndrome is IFNG-AS1 (IFNG Antisense RNA 1), and among its related pathways/superpathways are Apoptosis and Autophagy and NF-kappaB Signaling. The drugs Fluorometholone and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include eye, salivary gland and skin, and related phenotypes are keratoconjunctivitis sicca and xerostomia

Common Targets
FMN2 | XBP1 | IL23R | TNFSF4 | CD40LG | CGAS | OAS1 | SAP30L | TLR7 | KANSL1 | Protein Phosphatase 2B | JAK3 | PPIA | JAK1 | FAM167A | G596 | CRBN | CD247 | RORC | CCN1 | G3309 | TLR8 | G1956 | MALT1 | CA10 | TNPO3 | GTF2I | ABTB3 | CD6 | JAK2 | LRRK2 | HCP5 | AKNA | TNFSF13 | IFI44L | G3569 | FCGRT | G59272 | LPAR1 | ALDH3A2 | HIF1A | BTK | CHMP6 | ANO1 | CTSS | STAT6 | IL10RA | Mucin (nonspecified subtype) | APLNR | FKBP1A | IL2RA | VANGL1 | LRP5 | MSH5 | PPP3R2 | HLA-DQA1 | DUSP12 | BMX | FLT3LG | NF-kappaB (NFkB) | TYK2 | PPID | POGZ | PPP3CC | TNFSF13B | IL7R | DHODH | PANX1 | COMT | CD86 | PIK3CB | MICB | HLA-B | DRD2 | VCAM1 | SLC15A4 | G7852 | LILRA4 | XKR6 | NAPB | G4137 | HLA-DRB1 | FDX2 | NAB1 | PIK3CD | CCL11 | CASP4 | CD40 | UGT2B28 | CD22 | HLA-DRA | IgE Receptors (nonspecified subtype) | SYK | EBF1 | G3605 | BACE1 | FCGR3A | ACVR1 | NTRK1 | CHRM3 | GSK3B | ICOSLG | Immunoglobulin E (IgE) | IRF5 | CCR9 | TNFAIP3 | MICB-DT | MS4A1 | CELA1 | LINC02210-CRHR1 | G3630 | NCR3 | G2099 | RO60 | STAT4 | CD80 | LANCL2 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | G836 | TNFRSF13C | SSB | OSM | TNFRSF17 | ERN1 | IL12A-AS1 | NR3C1 | BLK | SIK2 | Janus Kinase (nonspecified subtype) | LINC01100 | RBMS3 | PTPN22 | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | SCN9A | LOC105374811 | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | FCGR2A | PDE4A | TACR1 | PPP3CB | PPP3R1 | ATF6 | MAP2K2 | SLU7 | HCAR2 | TNIP1 | NAMPT | Tubulin | FAS | HLA Class II Histocompatibility Antigen DQ8 | TLR9 | P2RX7 | FRZB | IFNG | CD28 | G2064 | PIK3CA | PRKCE | CKM | TNFRSF13B | HRH4 | S1PR1 | GRIN3B | Interleukin-7 receptor | SIK3 | CHRM2 | AOC3 | MICA | G7124 | IL6R | MTHFR | IL10 | RELN | H19 | TRIM8 | BANK1 | RIPK2 | TARBP1 | PPT1

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