Ewing Sarcoma

About the Disease
Ewing Sarcoma, also known as neuroepithelioma, is related to extraosseous ewing sarcoma and ewing sarcoma of bone, and has symptoms including eye manifestations, pain in or around eye and redness or discharge of eye. An important gene associated with Ewing Sarcoma is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways is Chromatin Regulation / Acetylation. The drugs Cobalt and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and bone marrow, and related phenotypes are peripheral primitive neuroectodermal neoplasm and nausea and vomiting

Common Targets
IDH1 | CD248 | BCR | GRB10 | G3845 | PIK3AP1 | NPTX2 | DNA-Directed RNA Polymerase (nonspecified subtype) | G3479 | G3480 | CD99 | FLT3 | ENG | PHF11 | CDK9/Cyclin T1 | RET | CDK9 | XIAP | CSF3R | GCNA | CTLA4 | MMP2 | ECHDC2 | INSR | G7157 | FHIT | STK11 | G4170 | ADGRG2 | RYR2 | FCGR3A | Mitogen-Activated Protein Kinase (nonspecified subtype) | PDGFRA | CLU | TEK | CCNT1 | EGR2 | APC | KIT | KCNA5 | HHEX | VHL | FLI1 | GNAS | G672 | CTNNB1 | MGMT | KDM1A | CREG1 | HNF1A | PTPN11 | NNAT | DNA-Directed RNA Polymerase II | NTSR1 | ADRA1D | RASSF6 | G596 | ABL1 | TOP2A | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | NAMPT | MLH1 | ABCC6 | DRD3 | TMEM127 | CEP41 | G2146 | G1029 | FGFR2 | RASSF1 | CLPP | G5728 | NEFH | BIRC5 | PDGFRB | CDK1 | CSF1R | HIF1A | ALDOC | MEST | G595 | PCDHB10 | IGF2 | CDK7 | G5243 | G1956 | PIK3CA | DRD2 | DNAJA4 | BRCA2 | CDK6 | CD3 Complex (T Cell Receptor Complex) | CDK2 | CDK4 | DNA-Directed DNA Polymerase Complex | RASSF2 | STEAP1 | Heat shock protein 90 (nonspecified subtype) | STAG2 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | TOP1 | PIK3CD | Protein Kinase B (PKB/Akt) (nonspecified subtype) | Tubulin | THBS1 | BRD4 | G9429 | CTHRC1 | G4233 | EWSR1 | PTPRD | CSF3 | KDR | FGFR1 | IKZF1 | MACF1 | RARRES2

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