Progressive Osseous Heteroplasia

About the Disease
Osseous Heteroplasia, Progressive, also known as progressive osseous heteroplasia, is related to myositis ossificans and ossification of the posterior longitudinal ligament of spine, and has symptoms including polydipsia and muscle weakness. An important gene associated with Osseous Heteroplasia, Progressive is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Signal Transduction and Akt Signaling. The drugs Etoricoxib and Cyclooxygenase 2 Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and skeletal muscle, and related phenotypes are subcutaneous nodule and limitation of joint mobility

Common Targets
GNAS | FAM111B

Note: If you'd like to get a target analysis report for Progressive Osseous Heteroplasia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Progressive Osseous Heteroplasia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Spinal And Bulbar Muscular Atrophy | Proteus Syndrome | Duchenne Muscular Dystrophy | Pompe Disease | Creatine Deficiency Syndrome | X-linked Acrogigantism | Hepatitis, Autoimmune | Hashimoto Thyroiditis | Nestor-Guillermo Progeria Syndrome | Methylmalonic Aciduria And Homocystinuria, CblC Type | Spinocerebellar Ataxia | ACTH-independent Macronodular Adrenal Hyperplasia | Arrhythmogenic Right Ventricular Cardiomyopathy | Retinitis | Depression | Encephalopathy, Glycine | Wolman Disease | Macular Corneal Dystrophy | Cranioectodermal Dysplasia | Hyperferritinemia-cataract Syndrome | Intestinal Hypomagnesemia 1 | Congenital Tufting Enteropathy | Colon Adenoma | Precocious Puberty | Cat Eye Syndrome | Juvenile Xanthogranuloma | Primary Hyperoxaluria Type 1 | Periventricular Leukomalacia | Congenital Nephrotic Syndrome | Oculocutaneous Albinism Type 4 | Bardet-Biedl Syndrome | Relapsing Polychondritis | Specific Granule Deficiency | Sarcoma, Alveolar Soft Part | Corneal Dystrophies, Hereditary | Progressive Myoclonic Epilepsy | Hartnup Disease | Fundus Albipunctatus | Congenital Myopathy | Hemangioendothelioma | Choroiditis | Protein S Deficiency | Hidradenitis | Beare-Stevenson Syndrome | Aicardi-Goutieres Syndrome | Rolandic Epilepsy | Temporal Lobe Epilepsy | Glycogen Storage Disease Type 4 | Panuveitis | Chronic Granulomatous Disease | Meleda Disease | Sponastrime Dysplasia | Triple A Syndrome | Interstitial Lung Diseases | Meckel-Gruber Syndrome | Diabetes Type 2 | Sleep Disorder | Glutaric Aciduria Type 2 | Arts Syndrome | Spinocerebellar Ataxia Type 1 | Lymphoma, B-cell | Corneal Neovascularization | Vitamin B12 Deficiency | Leukocyte Adhesion Deficiency | Myoclonus-dystonia Syndrome | Tuberculous Meningitis | Heterotopic Ossification | Blastomycosis | Fibronectin Glomerulopathy | Thrombocythemia, Essential | Hepatitis | Dysmorphophobia | Von Willebrand Disease | NDH Syndrome | Adenylosuccinate Lyase Deficiency | Hereditary Xerocytosis | Encephalocele | Hemorrhagic Disorders | Acute Kidney Injury | Glycogen Storage Disease Type 0 | Obsessive-compulsive Disorder | Dementia, Vascular | Crigler-Najjar Syndrome | Anuria | Spinocerebellar Ataxia Type 10 | Amyloidosis | Inflammatory Myofibroblastic Tumor | Atelosteogenesis Type 2 | KBG Syndrome | Farber Disease | Spinocerebellar Ataxia Type 16 | Leishmaniasis, Cutaneous | Hoyeraal-Hreidarsson Syndrome | Uveitis | Bloom Syndrome | Waardenburg Syndrome Type 2A | T-cell Lymphoma, Subcutaneous Panniculitis-like | Apraxia | Benign Familial Neonatal Convulsions | Headache | Maple Syrup Urine Disease | Osteomalacia | Familial Exudative Vitreoretinopathy | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Spasticity | Retinal Detachment | Orotic Aciduria | Stargardt Disease | Osteopathia Striata With Cranial Sclerosis | Chronic Granulomatous Disease, X-linked | Tendinitis | Cystitis, Interstitial | Acquired Partial Lipodystrophy | Dyslexia | Charcot-Marie-Tooth Disease Type 4 | Cutaneous Mastocytosis | Ectodermal Dysplasia | Osteitis | Megalencephaly | Primary Biliary Cholangitis | Mitochondrial Disease | Bulimia Nervosa | Seasonal Mood Disorder | Proteasome-associated Autoinflammatory Syndrome 2 | Babesiosis | Congenital Primary Aphakia | Neurofibromatosis Type 1 | Olmsted Syndrome | Cholestasis, Intrahepatic | MELAS Syndrome | McCune-Albright Syndrome | Hypertension, Renal | Rash | Blue Rubber Bleb Nevus Syndrome | Acromesomelic Dysplasia | Ectopia Lentis, Isolated, Autosomal Recessive | Primary Torsion Dystonia | Behcet's Disease | Harlequin Ichthyosis | Thrombosis | Angiodysplasia | Gastritis | Steel Syndrome | Bietti Crystalline Dystrophy | Prune Belly Syndrome | Xeroderma Pigmentosum | Hemorrhoids | Charcot-Marie-Tooth Disease Type 4B1 | Mandibuloacral Dysplasia With Type A Lipodystrophy | Hyperlipidemia Type V | Hypotrichosis | Anencephaly | Astrocytoma, Anaplastic | Achondrogenesis | Christianson Syndrome | Wiskott-Aldrich Syndrome | Common Variable Immunodeficiency | Ovarian Sex Cord-stromal Tumor | Gangliosidosis, GM1 | Myocarditis | Polydactyly | Epidermolysis Bullosa | Nephrotic Syndrome Type 1 | Cancer, Colon | Nijmegen Breakage Syndrome | Osteogenesis Imperfecta Type V | Infertility, Male | Mevalonate Kinase Deficiency | Focal Cortical Dysplasia Type 2 | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Encephalopathy, Ethylmalonic | Papulopustular Rosacea | Pericarditis | Micropenis | Tangier Disease | Leri-Weill Dyschondrosteosis | Otopalatodigital Syndrome Type 2 | Ureteropelvic Junction Obstruction | Spinocerebellar Ataxia Type 7 | IgA Nephropathy | Kearns-Sayre Syndrome | Temtamy Preaxial Brachydactyly Syndrome | Adrenoleukodystrophy, X-linked | Dysferlinopathy | Dowling-Degos Disease | Miyoshi Myopathy | Brooke-Spiegler Syndrome | Congenital Aniridia | Dyslipidemia | Raynaud Phenomenon | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Phosphoglycerate Dehydrogenase Deficiency | Alazami Syndrome | Pseudoachondroplasia | Chromosome 17q21.31 Deletion Syndrome | Leiomyoma | Hypoparathyroidism | Metaphyseal Chondrodysplasia, Schmid Type | Strabismus | Facioscapulohumeral Muscular Dystrophy Type 1 | Tuberculosis | Sick Sinus Syndrome | Silicosis | Neurodermatitis | Cannabis Abuse | Porphyria, Acute Intermittent | Autosomal Recessive Spastic Paraplegia Type 35 | Diffuse Mesangial Sclerosis | Vascular Calcification | Addison Disease | Asplenia | Cleidocranial Dysplasia | Wolff-Parkinson-White Syndrome | Dysgerminoma | Carbonic Anhydrase VA Deficiency | Cryptosporidiosis | Palmoplantar Keratoderma | Frontotemporal Dementia | Crisponi Syndrome | Osteogenesis Imperfecta Type VI | Congenital Stromal Corneal Dystrophy | Hypermetropia | Restless Legs Syndrome | WAGR Syndrome | Niemann-Pick Disease, Type A | Acral Lentiginous Melanoma | Avian Influenza | Angiomyolipoma | Empyema | Mucolipidosis Type II | Fetal Akinesia Deformation Sequence | Melanoma, Malignant | Obesity, Morbid | Genitopatellar Syndrome | Pineoblastoma | Cardiospondylocarpofacial Syndrome | Microphthalmia, Syndromic 7 | Hereditary Hemorrhagic Telangiectasia | Genee-Wiedemann Syndrome | Trichothiodystrophy | Mitochondrial DNA Depletion Syndrome 13 | Smoldering Myeloma | Hepatic Adenomatosis | Splenomegaly | Hemolytic Uremic Syndrome | Acute Coronary Syndrome | Odonto-onycho-dermal Dysplasia | Binge Eating Disorder | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Chronic Myeloid Leukemia | Retinopathy Of Prematurity | Hemochromatosis Type 2 | Influenza | Congenital Lipoid Adrenal Hyperplasia | Polymyositis | Coffin-Lowry Syndrome | Vestibular Disease | Haim-Munk Syndrome | Chondrodysplasia Punctata 1, X-linked Recessive | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Fucosidosis | Gastric Atrophy | Glaucoma | Purpura, Thrombotic Thrombocytopenic | Localized Scleroderma | Myofibromatosis | Nutrition Disorders | Diabetic Nephropathy | Micro Syndrome | Clouston Hidrotic Ectodermal Dysplasia | MIRAGE Syndrome | Hepatitis E | Chromosome 8q21.11 Deletion Syndrome | Amyotrophic Lateral Sclerosis, Juvenile | Jaundice, Obstructive | Corneal Dystrophy And Perceptive Deafness | Charcot-Marie-Tooth Disease, Type 6 | Thin Basement Membrane Disease | Postpartum Depression | Myasthenia | Menetrier Disease | Rhabdomyosarcoma | Azoospermia | Spinocerebellar Ataxia Type 12 | Primary Lateral Sclerosis | Guillain-Barre Syndrome | Polyneuropathy | Anosmia, Congenital | Disseminated Superficial Actinic Porokeratosis | Enterocolitis, Necrotizing | Epidermolysis Bullosa Simplex, Localized | Behavioral Variant Of Frontotemporal Dementia | Keratocystic Odontogenic Tumor | Schwartz-Jampel-Aberfeld Syndrome | Takotsubo Cardiomyopathy | Arthrogryposis | Lateral Meningocele Syndrome | Ophthalmia, Sympathetic | Tetraplegia | Blastoma, Pleuropulmonary | Congenital Heart Block | Encephalopathy, Hepatic | Hydrocephalus | Waardenburg Syndrome Type 4 | Thyroid Dysgenesis | Epidermolytic Hyperkeratosis | Parapsoriasis | Pemphigus | Renal Hypouricemia | Systemic Lupus Erythematosus | Neurogenic Bladder | Hypercalcemia | Hereditary Mixed Polyposis Syndrome | Pityriasis Rubra Pilaris | Gerodermia Osteodysplastica | Alzheimer Disease, Late Onset | Loeys-Dietz Syndrome | Dystrophy, Cone-rod | Epidermolysis Bullosa Simplex, Generalized | Teratozoospermia | Superficial Spreading Melanoma | Cole-Carpenter Syndrome | Pituitary Stalk Interruption Syndrome | Panniculitis | Leukoplakia, Oral | Brenner Tumor | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Juvenile Myoclonic Epilepsy | Neuropathy | Corneal Ulcer | IMAGe Syndrome | Nance-Horan Syndrome | Fowler's Syndrome | Disseminated Intravascular Coagulation | Toxoplasmosis | Saethre-Chotzen Syndrome | Werner's Syndrome | Scoliosis | Diabetes Insipidus, Neurogenic | Asphyxia Neonatorum | X-linked Myotubular Myopathy | Heimler Syndrome | Riboflavin Transporter Deficiency Neuronopathy | Schistosomiasis | Granular Corneal Dystrophy Type 1 | Lymphangiomatosis | Charcot-Marie-Tooth Disease Type 2E | Leishmaniasis, Visceral | Periventricular Nodular Heterotopia | Dent Disease | Distal Myopathy 2 | Spinocerebellar Ataxia Type 42 | Amish Infantile Epilepsy Syndrome | Prostatitis | Intermittent Claudication | Shprintzen-Goldberg Syndrome | Cabezas Syndrome | Greenberg Dysplasia | Benign Familial Pemphigus | Seizures | Mixed Connective Tissue Disease | Leprosy | Erysipelas | Peroxisomal Disorder | Chronic Idiopathic Myelofibrosis | Mannosidase Deficiency Diseases | Isovaleric Acidemia | Ghosal Syndrome | Ameloblastic Carcinoma | Pneumonia, Viral | Keloid | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Spondyloepiphyseal Dysplasia Tarda, X-linked | Prurigo Nodularis | Salla Disease | Charcot-Marie-Tooth Disease Type 4D | Metanephric Adenoma | Intestinal Obstruction | Perry Syndrome | T-cell Chronic Lymphocytic Leukemia | Gnathodiaphyseal Dysplasia | Hereditary Elliptocytosis | Dystonia | L-2-Hydroxyglutaric Aciduria | Facioscapulohumeral Muscular Dystrophy | Molybdenum Cofactor Deficiency | Basal Cell Nevus Syndrome | Leiomyosarcoma | Hypotonia-cystinuria Syndrome | Charcot-Marie-Tooth Disease, Type 2A | Prolymphocytic Leukemia | Infantile Spasm | Snyder-Robinson Syndrome | Osteoarthritis | Restrictive Dermopathy | Glucagonoma | Sarcomatoid Carcinoma Of The Lung | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Pitt-Hopkins Syndrome | Learning Disability