Spasticity

About the Disease
Spasticity is related to spastic paraplegia 41, autosomal dominant and spastic paraplegia 19, autosomal dominant. An important gene associated with Spasticity is SPAST (Spastin), and among its related pathways/superpathways is Sudden infant death syndrome (SIDS) susceptibility pathways. The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and skeletal muscle, and related phenotypes are nervous system and growth/size/body region

Common Targets
Alpha-2 Adrenergic receptors (nonspecified subtype) | HTR1A | Nicotinic alpha4beta2alpha5 Receptor | Kainate Receptor (GluR) (nonspecified subtype) | GABA(A) receptor | Gamma-Aminobutyric acid type B receptor | Voltage-Gated Sodium Channel Complex | MGLL | KCNQ3 | Sodium channel (nonspecified subtype) | SCN3A | TRPV2 | G1/S-specific cyclin-E (nonspecified subtype) | SCN8A | CHRNA7 | Guanylate cyclase (nonspecified subtype) | SLC6A9 | OPRD1 | Nicotinic alpha4beta2 receptor | SCN4A | Myosin Class II (nonspecified subtype) | NMDA receptor | TRPA1 | PTGDR2 | GABRA1 | MYH2 | SCN9A | EXOSC3 | CCNE1 | SCN1A | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | Glycine receptor | SLC2A1 | Cannabinoid receptor (nonspecified subtype) | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | GPR55 | SCN5A | MAOB | GABRA2 | CDK2/Cyclin E | G595 | OPRM1 | CHRNB2 | Neuronal acetylcholine receptor alpha2beta2 receptor | ABAT | CNR2 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | KCNQ2 | SCN2A | Glutamate Receptor Ionotropic AMPA Receptor | Calcium channel (nonspecified subtype) | CDK2 | CDK4 | SLC6A5 | SCN10A | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | Nicotinic alpha1beta1deltaepsilon Receptor | CDK4/Cyclin D1 | Protein kinase C (nonspecified subtype) | TRPM8 | CNR1 | MAOA | TRPV1

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