Polyneuropathy

About the Disease
Polyneuropathy, also known as polyneuropathies, is related to amyloidosis, hereditary, transthyretin-related and chronic inflammatory demyelinating polyradiculoneuropathy, and has symptoms including neuralgia An important gene associated with Polyneuropathy is GDAP1 (Ganglioside Induced Differentiation Associated Protein 1), and among its related pathways/superpathways are Guidance Cues and Growth Cone Motility and Intracellular trafficking proteins involved in CMT neuropathy. The drugs Imipramine and Levetiracetam have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, liver and brain, and related phenotypes are no effect and no effect

Common Targets
AARS1 | PDXK | G23411 | CHRM1 | ABHD16A | FCGR3A | DNM2 | GSTP1 | POLG | CTNNB1 | FCGR2A | CD59 | ARHGEF10 | ATP8 | G6647 | CAT | G5243 | TTR | AIFM1

Note: If you'd like to get a target analysis report for Polyneuropathy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Polyneuropathy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Cherubism | Optic Neuropathy, Anterior Ischemic | Dysfibrinogenemia | Liebenberg Syndrome | Tetanus | Iron Overload | Parkinson's Disease | Fetal Alcohol Syndrome | Persistent Hyperplastic Primary Vitreous | Pseudoachondroplasia | Osteonecrosis | Lymphoma, B-cell | Adenomyosis | H Syndrome | Thromboembolism | Anxiety Disorders | Osteosarcoma | Sjogren Syndrome | Cancer, Bladder | Alazami Syndrome | DNA Ligase IV Deficiency | Episodic Ataxia Type 1 | Chronic Idiopathic Myelofibrosis | Juvenile Polyposis | Atrial Septal Defect | Uremia | Tenosynovial Giant Cell Tumor | Rubinstein-Taybi Syndrome | Thrombotic Microangiopathy | GLUT1 Deficiency Syndrome | Lupus Erythematosus | Gyrate Atrophy Of The Choroid And Retina | Sepiapterin Reductase Deficiency | Autonomic Neuropathy | Syncope | Frank-ter Haar Syndrome | Kaposiform Hemangioendothelioma | Traboulsi Syndrome | Thrombosis | Porphyria, Variegate | Tuberculosis | Schizoaffective Disorder | Progressive Familial Intrahepatic Cholestasis Type 3 | Pontocerebellar Hypoplasia Type 7 | Epidermolysis Bullosa Dystrophica | Bicuspid Aortic Valve | Cenani-Lenz Syndactyly Syndrome | Toxic Epidermal Necrolysis | Dysferlinopathy | Hyperinsulinism-hyperammonemia Syndrome | Anosmia, Congenital | Hepatopulmonary Syndrome | Central Core Disease | Seminoma | Lattice Corneal Dystrophy | FG Syndrome | Myasthenia | Vestibular Disease | Pachyonychia Congenita | Cerebellar Ataxia, Cayman Type | Arthritis | Antisocial Personality Disorder | Arteriosclerosis | Chondrodysplasia Punctata 1, X-linked Recessive | Methylmalonic Acidemia | Asplenia | Primary Cutaneous Amyloidosis | Hypertrophy | Sclerosteosis 2 | Neurofibroma | Osteoarthritis | 5-oxoprolinase Deficiency | Glutaric Aciduria Type 3 | Nemaline Myopathy | Keratopathy | Alveolar Capillary Dysplasia | Renal Failure | Basal Cell Nevus Syndrome | Blue Nevus | Bronchiectasis | Papillorenal Syndrome | Mitochondrial DNA Depletion Syndrome | Methemoglobinemia | Acute Chest Syndrome | Neuroma | Chronic Granulomatous Disease, X-linked | Sengers Syndrome | Hyperacusis | Lipid Storage Diseases | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Omenn Syndrome | Thrombasthenia | Heavy Chain Disease | Hypohidrotic Ectodermal Dysplasia, X-linked | Barrett Esophagus | Multicystic Renal Dysplasia | Hemangioma | Diffuse Mesangial Sclerosis | Angiosarcoma | Multisystemic Smooth Muscle Dysfunction Syndrome | Hypertension, Renal | Hypermetropia | Hernia, Inguinal | Lichen Planus | Megalencephaly | Infantile Spasm | Rothmund-Thomson Syndrome | Familial Retinal Arterial Macroaneurysm | Shock, Cardiogenic | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Chondroma | Schnyder Crystalline Corneal Dystrophy | Porokeratosis | Inflammatory Bowel Disease | Hepatic Veno-occlusive Disease | Congenital Disorders Of Glycosylation | Parapsoriasis | Fanconi Anemia | Pneumothorax | Congenital Bilateral Absence Of Vas Deferens | Trichomegaly | Phenylketonuria II | Aldosterone Synthase Deficiency | Familial Pheochromocytoma-paraganglioma | Primary Lateral Sclerosis | Pure Autonomic Failure | Pigment Dispersion Syndrome | Costello Syndrome | Multifocal Motor Neuropathy | Split Hand-foot Malformation | Non-bullous Congenital Ichthyosiform Erythroderma | Tendinitis | Thymoma, Malignant | Scapuloperoneal Myopathy, X-linked Dominant | Arrhythmogenic Right Ventricular Cardiomyopathy | Atelosteogenesis Type 2 | Benign Hereditary Chorea | Rett Syndrome | Vasculitis | Niemann-Pick Disease, Type C | Orotic Aciduria | Pernicious Anemia | Osteogenesis Imperfecta Type V | Fontaine Progeroid Syndrome | Bacterial Meningitis | Japanese Encephalitis | Early Infantile Epileptic Encephalopathy 28 | Venous Insufficiency | 3-methylglutaconic Aciduria Type IV | Schnitzler Syndrome | Purpura | Thrombocythemia, Essential | Homocystinuria | Pycnodysostosis | Vitreoretinal Degeneration, Snowflake Type | Choriocarcinoma | Vitamin A Deficiency | Usher Syndrome | Currarino Syndrome | Hemimegalencephaly | Anovulation | Oligoastrocytoma | Colitis, Collagenous | Vitiligo | Blepharo-cheilo-odontic Syndrome | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Focal Segmental Glomerulosclerosis | Cone Dystrophy | Schistosomiasis Mansoni | Malonyl-CoA Decarboxylase Deficiency | Hypothalamic Obesity | Barakat Syndrome | Tremor | NGLY1 Deficiency | Endocarditis | Seasonal Mood Disorder | Gangliosidosis | Borderline Personality Disorder | CHOPS Syndrome | Arteriovenous Malformations | Skin Carcinoma | Hoyeraal-Hreidarsson Syndrome | Stroke | Paracoccidioidomycosis | Heart Failure | Spondyloepiphyseal Dysplasia Tarda, X-linked | Cancer, Kidney | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Progressive External Ophthalmoplegia | Ischemia | Hypercalcemia | Heimler Syndrome | Stroke, Hemorrhagic | Nephrotic Syndrome | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Niemann-Pick Disease, Type A | Niemann-Pick Disease, Type B | Rheumatoid Arthritis | Desmosterolosis | Mitochondrial Myopathy | Geleophysic Dysplasia | Reye Syndrome | Greenberg Dysplasia | Polyneuropathy | Erysipelas | Birt-Hogg-Dube Syndrome | Vitreoretinopathy, Proliferative | Dengue Shock Syndrome | Anorectal Fistula | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Neovascular Glaucoma | Teratozoospermia | Ganglioglioma | B-cell Prolymphocytic Leukemia | Alopecia Areata | Corneal Dystrophies, Hereditary | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Spinocerebellar Ataxia Type 31 | Gastroenteritis, Eosinophilic | Diabetes Insipidus, Nephrogenic | Synovitis | Cousin Syndrome | Vascular Calcification | Autism Spectrum Disorders | Hyperparathyroidism, Secondary | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Hemangioendothelioma | Autoimmune Disease | Scapuloperoneal Spinal Muscular Atrophy | Chorea-acanthocytosis | Rhabdoid Tumor | Atopic Dermatitis | Down Syndrome | Waardenburg Syndrome | Thanatophoric Dysplasia | Trichuriasis | Restless Legs Syndrome | Hypokalemia | Trichothiodystrophy | Kashin-Beck Disease | Acromicric Dysplasia | Primary Hyperoxaluria | Sarcoma, Alveolar Soft Part | Multiple Myeloma | Smith-Lemli-Opitz Syndrome | Gangliosidosis, GM1 | Tyrosinemia | Usher Syndrome Type II | Primary Aldosteronism | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Pompe Disease | Heterotaxy | Kleine-Levin Syndrome | Adenocarcinoma | Osteochondroma | Biotinidase Deficiency | Uveitis, Anterior | Aromatic L-amino Acid Decarboxylase Deficiency | Retinal Diseases | Hyperbilirubinemia, Neonatal | Nestor-Guillermo Progeria Syndrome | Cancer, Breast | Methylmalonic Aciduria And Homocystinuria, CblC Type | Lymphoma, AIDS-related | T-cell Chronic Lymphocytic Leukemia | ADNP Syndrome | Trigonocephaly | Renal Hypouricemia | Maternally Inherited Diabetes And Deafness | Goldenhar Syndrome | Pathological Gambling | Hepatitis E | Alpha-1 Antitrypsin Deficiency | Spermatocele | N-acetylglutamate Synthase Deficiency | Von Willebrand Disease | Sclerocornea | Epidermolysis Bullosa | Familial Partial Lipodystrophy | Alpha-mannosidosis | Birk-Barel Syndrome | Dentinogenesis Imperfecta | Erythema Nodosum | Adenoma, Villous | Spondyloarthritis | Hypodontia | Blepharoconjunctivitis | Motor Neuron Diseases | Benign Familial Infantile Seizures | Combined Deficiency Of Factor V And Factor VIII | Peutz-Jeghers Syndrome | Genitopatellar Syndrome | Galactosemia | Ganglioneuroma | Acute Motor Axonal Neuropathy | Glaucomatocyclitic Crisis | Brachial Plexus Neuropathy | D-2-Hydroxyglutaric Aciduria | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Alcoholism | Urea Cycle Disorder | Majeed Syndrome | Asphyxia Neonatorum | Hemosiderosis | Bone Giant Cell Tumor | Papilledema | Parvovirus B19 Infection | Muscle Wasting | DiGeorge Syndrome | Dermatitis Herpetiformis | Hemorrhagic Disorders | Chronic Neutrophilic Leukemia | Liver Failure | Photosensitivity | T-cell Lymphoma, Subcutaneous Panniculitis-like | Pheochromocytoma | Meier-Gorlin Syndrome | Cancer, Colon | Congenital Stationary Night Blindness | Opisthorchiasis | Specific Granule Deficiency | Cutaneous T-cell Lymphoma | Huntington's Disease-like 2 | Keratosis, Actinic | Phenylketonuria | Cyst | Dysmorphophobia | Obsessive-compulsive Disorder | Hairy Cell Leukemia | Cavitary Optic Disc Anomalies | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Prostatitis | Smoldering Myeloma | Palmoplantar Keratoderma | Toxoplasmosis | Ophthalmoplegia | Apparent Mineralocorticoid Excess Syndrome | Autoimmune Polyendocrinopathy Syndrome Type I | Retinal Coloboma | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Skin Fragility-woolly Hair Syndrome | Metachromatic Leukodystrophy | Enhanced S-cone Syndrome | Hyperandrogenemia | Ichthyosis Hystrix, Curth-Macklin Type | Trismus-pseudocamptodactyly Syndrome | Ocular Surface Squamous Neoplasia | Stuve-Wiedemann Syndrome | Vaginitis | Heroin Dependence | Myelitis, Transverse | Situs Inversus | Overactive Bladder | Diarrhea | Pulmonary Sclerosing Hemangioma | Familial Cerebral Amyloid Angiopathy | Hereditary Pyropoikilocytosis | Peters-plus Syndrome | Lipoma | Osteogenesis Imperfecta Type I | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Cervical Dystonia | Personality Disorders | Paroxysmal Nocturnal Hemoglobinuria | Glycogen Storage Disease Type 4 | Macular Corneal Dystrophy Type 1 | Thyroid Dyshormonogenesis | Dental Caries | Immunoproliferative Disorders | Metaphyseal Chondrodysplasia, Schmid Type | Growth Hormone Excess | Episodic Ataxia Type 2 | Synpolydactyly | Combined Malonic And Methylmalonic Acidemia | Graves Disease | Lymphedema-distichiasis Syndrome | Usher Syndrome Type I | Diabetic Encephalopathy | Woodhouse-Sakati Syndrome | Leukocyte Adhesion Deficiency Type 1 | Marinesco-Sjogren Syndrome | Epidermolysis Bullosa Simplex, Generalized | Optic Neuritis | Spondylometaphyseal Dysplasia | Liver Diseases | Intestinal Pseudo-obstruction | Stargardt Disease | Oculopharyngeal Muscular Dystrophy | Stomatitis | Liddle Syndrome | Richter's Syndrome | Sarcoma, Ewing | Granuloma Annulare | Epidermolysis Bullosa Simplex | Congenital Adrenal Hyperplasia | Pouchitis | Myotonic Disorders | Anthrax | Pfeiffer Syndrome | Alexander Disease