Disease

Polyneuropathy

About the Disease
Polyneuropathy, also known as polyneuropathies, is related to amyloidosis, hereditary, transthyretin-related and chronic inflammatory demyelinating polyradiculoneuropathy, and has symptoms including neuralgia An important gene associated with Polyneuropathy is GDAP1 (Ganglioside Induced Differentiation Associated Protein 1), and among its related pathways/superpathways are Guidance Cues and Growth Cone Motility and Intracellular trafficking proteins involved in CMT neuropathy. The drugs Imipramine and Levetiracetam have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, liver and brain, and related phenotypes are no effect and no effect

Common Targets
AARS1 | PDXK | G23411 | CHRM1 | ABHD16A | FCGR3A | DNM2 | GSTP1 | POLG | CTNNB1 | FCGR2A | CD59 | ARHGEF10 | ATP8 | G6647 | CAT | G5243 | TTR | AIFM1

疾病靶点研报
Polyneuropathy

Note: If you'd like to get a target analysis report for Polyneuropathy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Polyneuropathy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Dystonia Musculorum Deformans | Kaposi Sarcoma | Palmoplantar Keratoderma | Arts Syndrome | Adenomyosis | TARP Syndrome | B-cell Chronic Lymphocytic Leukemia | Anorchia | Angina Pectoris | Leukemia-lymphoma, Adult T-cell | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Primary Familial Brain Calcification | Early Infantile Epileptic Encephalopathy 13 | Autonomic Neuropathy | Bullous Pemphigoid | Pulmonary Veno-occlusive Disease | Urofacial Syndrome | Pseudoexfoliation Syndrome | Retinoblastoma | Biotinidase Deficiency | Hepatitis, Chronic | Myoclonus | Non-Hodgkin Lymphoma | Glomerulonephritis, Membranous | Warsaw Breakage Syndrome | Myasthenia | Mucolipidosis Type II | Leukemia | Splenomegaly | Nemaline Myopathy 8 | Methemoglobinemia Type IV | Chromosome 16p11.2 Deletion Syndrome | Genee-Wiedemann Syndrome | Glycogen Storage Disease Type 1a | Aspartylglycosaminuria | Hypocalcemia | Infantile Spasm | Spinocerebellar Ataxia Type 23 | PHARC Syndrome | Myocardial Infarction | Ileitis | Macrophage Activation Syndrome | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Adenoma, Pituitary | Ebstein Anomaly | Spinocerebellar Ataxia Type 6 | Pseudoachondroplasia | Leukocyte Adhesion Deficiency Type 1 | Erythromelalgia | Neurodevelopmental Disorders | Usher Syndrome Type I | Birk-Barel Syndrome | Fontaine Progeroid Syndrome | Coenzyme Q10 Deficiency | Central Pain Syndrome | Palsy, Cerebral | Charcot-Marie-Tooth Disease Type 2T | Aspergillosis | Primary Biliary Cholangitis | Congenital Hereditary Endothelial Dystrophy Type II | Amelogenesis Imperfecta | COACH Syndrome | Muckle-Wells Syndrome | Globozoospermia | Epilepsy, Generalized | Methemoglobinemia | Familial Glucocorticoid Deficiency | Autoimmune Polyendocrine Syndrome | Diabetes Insipidus, Nephrogenic | Robinow Syndrome | Allan-Herndon-Dudley Syndrome | Camptocormia | Skin Papilloma | Bethlem Myopathy | Glycogen Storage Disease Type 9 | Scapuloperoneal Myopathy, X-linked Dominant | Pelizaeus-Merzbacher Disease | Pre-eclampsia | Poretti-Boltshauser Syndrome | Arthritis, Reactive | Charcot-Marie-Tooth Disease, Type 2A | Johanson-Blizzard Syndrome | Hemolytic Anemia | Persistent Hyperplastic Primary Vitreous | Oligodendroglioma | Systemic Lupus Erythematosus | Hypoproteinemia, Hypercatabolic | Basan Syndrome | 3-methylglutaconic Aciduria Type IV | Scapuloperoneal Spinal Muscular Atrophy | Ichthyosis | Craniofrontonasal Syndrome | Cutaneous Angiosarcoma | Glycogen Storage Disease | Schistosomiasis | Polyradiculopathy | Neurocutaneous Syndromes | Tendinitis | Hyperbilirubinemia, Neonatal | Episodic Ataxia | Oculocutaneous Albinism Type 4 | Cavitary Optic Disc Anomalies | Abetalipoproteinemia | Communication Disorders | Colon Adenoma | Diabetic Nephropathy | Acquired Partial Lipodystrophy | Chromosome 17q21.31 Deletion Syndrome | Motor Neuron Diseases | Retinal Coloboma | Autonomic Nervous System Disorders | Acute Kidney Injury | Dupuytren Disease | Lysosomal Acid Lipase Deficiency | Pseudo-pseudohypoparathyroidism | Arthritis | Hydrocephalus | IgA Nephropathy | Saethre-Chotzen Syndrome | Parapsoriasis | Pneumoconiosis | Evans Syndrome | Antley-Bixler Syndrome | Ornithine Transcarbamylase Deficiency | Sickle Cell Disease | Primary Carnitine Deficiency | Pernicious Anemia | Niemann-Pick Disease, Type C | Dental Caries | Autosomal Recessive Spastic Paraplegia Type 75 | Cocaine-Related Disorders | Chronic Periodontitis | Chorea-acanthocytosis | Desmosterolosis | Chronic Lymphocytic Leukemia | Alazami Syndrome | Coronary Restenosis | Ischemia | Mast Cell Leukemia | Nephrotic Syndrome Type 1 | Optic Atrophy 2 | Familial Hemiplegic Migraine | Microphthalmia, Syndromic 7 | Central Retinal Artery Occlusion | Iron Overload | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Cerebellar Ataxia, Cayman Type | Varices | Hoyeraal-Hreidarsson Syndrome | Fetal Alcohol Syndrome | Spina Bifida | Stargardt Disease | Frontometaphyseal Dysplasia | Recurrent Respiratory Papillomatosis | Craniometaphyseal Dysplasia | Silicosis | Norrie Disease | Follicular Dendritic Cell Sarcoma | Arthritis, Gouty | Woodhouse-Sakati Syndrome | Tay-Sachs Disease | Pneumococcal Meningitis | Essential Fructosuria | Amblyopia | Dyggve-Melchior-Clausen Disease | Arteriovenous Malformations | Hyperlipidemia | Pontocerebellar Hypoplasia | Zellweger Syndrome | Melanoma, Malignant | Bone Marrow Necrosis | Sweet Syndrome | Esophageal Adenocarcinoma | Carney-Stratakis Syndrome | Gastroenteritis, Eosinophilic | Congenital Fiber-type Disproportion Myopathy | Antisocial Personality Disorder | Pneumonia, Viral | Stomatitis | Isobutyryl-CoA Dehydrogenase Deficiency | Spinocerebellar Ataxia Type 3 | Tyrosinemia Type 1 | Hyperbilirubinemia | Adult Polyglucosan Body Disease | Tinea Versicolor | Herpes Simplex Dermatitis | Microvillus Inclusion Disease | Progressive Familial Intrahepatic Cholestasis Type 2 | Prune Belly Syndrome | Angioedema, Acquired | Cherubism | Hemochromatosis Type 2 | Myocarditis | Congenital Mirror Movements | Chronic Myelomonocytic Leukemia | Antithrombin III Deficiency | Shock, Cardiogenic | Pemphigoid | Becker Muscular Dystrophy | Photosensitivity | X-linked Acrogigantism | Pancytopenia | T-cell Chronic Lymphocytic Leukemia | Paraganglioma, Carotid Body | Spinal Cord Diseases | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Idiopathic Multicentric Castleman Disease | Osteogenesis Imperfecta Type I | Nijmegen Breakage Syndrome | Lactose Intolerance | Amyotrophic Lateral Sclerosis, Juvenile | Lipid Storage Myopathy | Crigler-Najjar Syndrome | Addison Disease | Speech Disorders | Nestor-Guillermo Progeria Syndrome | Situs Inversus | Nevus | Ophthalmia, Sympathetic | Spondylometaphyseal Dysplasia | Congenital Hereditary Endothelial Dystrophy Type I | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Dwarfism | Adenomatoid Tumor | Influenza | Gastroschisis | Peripheral Neuropathy | Reticular Dysgenesis | Rhizomelic Chondrodysplasia Punctata | Diabetes | Renal Oncocytoma | Neuromuscular Disorders | Asthma, Exercise-induced | Dysthymia | Gilbert Syndrome | Subacute Sclerosing Panencephalitis | Nephrocalcinosis | Neurofibromatosis | Panic Disorder | Gangliosidosis, GM1 | Hidradenitis | Hypertensive Retinopathy | Klippel-Feil Syndrome | Hydrops Fetalis | Hypertension, Renal | Anovulation | Smoldering Myeloma | Triphalangeal Thumb-polysyndactyly Syndrome | Kaposiform Hemangioendothelioma | Melanoma, Uveal | Plasma Cell Leukemia | Glycogen Storage Disease Type 0 | DEND Syndrome | Muir-Torre Syndrome | Rift Valley Fever | 3C Syndrome | Occipital Neuralgia | Mixed Connective Tissue Disease | Dysplastic Nevus | Thin Basement Membrane Disease | Papulopustular Rosacea | Lesch-Nyhan Syndrome | Pneumothorax | Cholecystitis | Creatine Deficiency Syndrome | Chondromyxoid Fibroma | Conn Syndrome | Epidermolysis Bullosa | Mucolipidosis | Metachondromatosis | Limb Girdle Muscular Dystrophy | Endometritis | HANAC Syndrome | Subcortical Band Heterotopia | Batten Disease | Pycnodysostosis | Waardenburg Syndrome Type 2E | Odonto-onycho-dermal Dysplasia | Retinoschisis | Light Chain Amyloidosis | Optic Neuropathy | Hermansky-Pudlak Syndrome | Waardenburg Syndrome | Kernicterus | Corneal Dystrophy And Perceptive Deafness | Takotsubo Cardiomyopathy | Marfan Syndrome | Motion Sickness | Sickle Cell Anemia | Otosclerosis | Adenosine Deaminase 2 Deficiency | 3-methylglutaconic Aciduria Type I | Bursitis | Japanese Encephalitis | Progressive External Ophthalmoplegia | Polyomavirus Nephropathy | Multiple Myeloma | Leukodystrophies | Spinocerebellar Ataxia Type 2 | Hyper IgE Syndrome | Aphasia | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Blue Nevus | Herpes Genitalis | Combined Malonic And Methylmalonic Acidemia | Amish Infantile Epilepsy Syndrome | Measles | Congenital Heart Defects | Carpal Tunnel Syndrome | Conjunctivitis, Allergic | Spondylocarpotarsal Synostosis Syndrome | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Panuveitis | Galactosemia | Osteogenesis Imperfecta Type III | Cervicitis | Glycogen Storage Disease Type 4 | Long QT Syndrome Type 2 | Dystonia-parkinsonism, X-linked | Sensorineural Hearing Loss | Keratitis-ichthyosis-deafness Syndrome | Multiple Sclerosis, Primary Progressive | Diffuse Intrinsic Pontine Glioma | Fatty Aldehyde Dehydrogenase Deficiency | Actinomycetoma | DOCK8 Immunodeficiency Syndrome | Weill-Marchesani Syndrome | Axenfeld-Rieger Syndrome | C3 Glomerulonephritis | Distal Myopathy | Brachydactyly | NDH Syndrome | Budd-Chiari Syndrome | Autoimmune Disease | Pituitary Stalk Interruption Syndrome | Miyoshi Myopathy | Pupil Disorders | Wolcott-Rallison Syndrome | Meckel-Gruber Syndrome | Metatropic Dysplasia | Hyperlipidemia, Familial Combined | Vascular Calcification | HUPRA Syndrome | Partington Syndrome | Eosinophilia | Hepatitis, Autoimmune | Holoprosencephaly | Autosomal Recessive Congenital Ichthyosis | 3-M Syndrome | Aplastic Anemia | Goiter, Nodular | Hemophagocytic Lymphohistiocytosis | Aicardi-Goutieres Syndrome | Lymphopenia | Anorectal Fistula | Glutaric Aciduria Type 2 | Hyperkalemic Periodic Paralysis | Carney Triad | Anodontia | Congenital Disorders Of Glycosylation | Sarcoma, Endometrial Stromal | FG Syndrome | Acute Motor Axonal Neuropathy | Trichuriasis | Myofibrillar Myopathy | Swine Influenza | Ulcerative Colitis | DICER1 Syndrome | Blepharospasm | Tendinopathy | LMNA-related Congenital Muscular Dystrophy | Nephroblastoma | Hypersensitivity | Pneumonia, Mycoplasma | Macular Corneal Dystrophy Type 1 | Spinocerebellar Ataxia Type 15 | Pulmonary Vein Stenosis | Cervical Dystonia | Bruck Syndrome | Anxiety Disorders | Enterocolitis, Necrotizing | Hypercalcemia | Filariasis | Glaucoma | Retinopathy Of Prematurity | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Primary Progressive Nonfluent Aphasia | Oculocutaneous Albinism | Myelodysplasia | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Mood Disorder | Coffin-Siris Syndrome | Christianson Syndrome | Hemoglobinopathies | Castleman Disease | Acute Anterior Uveitis | Venous Insufficiency | Orotic Aciduria | Anemia | Colitis, Collagenous