Anxiety Disorders

About the Disease
Anxiety, also known as anxiety disorders, is related to generalized anxiety disorder and separation anxiety disorder, and has symptoms including nervousness, agitation and feeling tense. An important gene associated with Anxiety is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and Class A/1 (Rhodopsin-like receptors). The drugs Amlodipine and Lorazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and thyroid, and related phenotypes are nervous system and normal

Common Targets
BBS9 | PDE4B | TACR2 | HDAC10 | PPARA | CDK6 | Prostaglandin EP Receptor (nonspecified subtype) | CACNA2D1 | GRM5 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | DRD2 | PIEZO2 | MAD1L1 | HTR1F | Protein kinase C (nonspecified subtype) | LOC105377329 | GPR88 | NCAN | CDK4 | L-type voltage-dependent calcium channel complex | GDNF-AS1 | Kainate Receptor (GluR) (nonspecified subtype) | ADRA1A | KCNN3 | CYSLTR1 | SLC18A2 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | TCEA2 | GABRA4 | Calcium channel (nonspecified subtype) | MKNK2 | TOP1 | TRPM8 | G2475 | FKBP4 | CRY2 | NOS1 | MTNR1A | CHRM4 | COMT | DRD4 | MANEA | KCNQ4 | DAO | ESR2 | DCAF15 | Gamma-Aminobutyric acid type B receptor | MAOA | HTR1A | PPARG | GRIN2C | Tachykinin Receptor (nonspecified subtype) | CNR1 | LTA | HABP2 | ROCK1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | TYR | ITIH3 | ADRA2B | SLC6A2 | Lipoxygenase (nonspecified subtype) | MGLL | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | ALDH2 | SIGMAR1 | RGS13 | NPSR1 | GPR52 | TRPV1 | G5594 | NPY1R | HRH2 | Estrogen receptor (nonspecified subtype) | AVPR1B | RXFP3 | CHRM1 | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | TRPC5 | KCNQ3 | CDC73 | GABRG2 | GPNMB | TXNRD2 | BMAL2 | GABRB2 | CDK5 | HDAC1 | PTGS1 | APLNR | GAL | G2099 | GCK | Kir 3.1/3.4 | G23411 | CCKBR | LINC00882 | NR3C1 | ADORA1 | HTR4 | GABA(A) receptor | HTR2B | PDE10A | KCNA4 | P2RX3 | ACHE | PDE1C | GRM6 | HSD11B1 | ITIH4 | ADORA2A-AS1 | DYRK1A | CALM1 | TRPV2 | SSTR3 | HCRTR1 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | HDAC3 | MC2R | PDE9A | Voltage-Gated Sodium Channel Complex | ACSS2 | G5743 | Glutamate Transporter (nonspecified subtype) | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | alpha-Adrenoceptor (nonspecified subtype) | KCNK2 | DBH | DPP4 | GRM2 | SPECC1L-ADORA2A | Neurotrophic Factor (nonspecified subtype) | ADORA2A | CACNB2 | GRIN2D | NAV1 | G1385 | CACNA1C | Opioid receptor (nonspecified subtype) | SYK | GALR3 | CHRNA7 | Tyrosine Kinase (nonspecified subtype) | DRD5 | AKR1B1 | G5243 | TMEFF2 | XDH | ADRA2A | OXT | BCHE | SLC6A9 | NPY2R | ADCY2 | Nicotinic alpha3beta4 Receptor | G4318 | Sodium channel (nonspecified subtype) | G4137 | GSK3B | Nicotinic alpha4beta2 receptor | G367 | MTNR1B | G4233 | Histone acetyltransferase (HAT) (nonspecified subtype) | GRM7 | NR1H4 | TMEM132D | UCHL5 | GLO1 | TMPRSS11D | Kir 3.1/3.2 | NTSR2 | SCN4A | UTS2R | HTR5A | MC3R | OPRL1 | SLC12A5 | Mitogen-Activated Protein Kinase (nonspecified subtype) | GABRG3 | ERCC2 | FKBP5 | OPRD1 | IL10 | SLC22A2 | SSTR4 | KCNJ3 | ADORA3 | GRIN2A | SAT1 | Pim Kinase (nonspecified subtype) | KCNQ Channels (K(v) 7) (nonspecified subtype) | SLC45A4 | TSPO | NPY | CHRM3 | Orexin receptor (nonspecified subtype) | SLC6A4 | GABRB3 | ARVCF | NPY5R | GABRA1 | PRF1 | DRD1 | RAF1 | RGS18 | DLG4 | MMP2 | POLG | MME | HCRTR2 | PTGDR2 | ADRB1 | OGT | FAAH | SLC6A11 | GRM8 | TRIM55 | Trypsin (nonspecified subtype) | P2RY12 | G7422 | PTPN5 | IL1B | ABCC8 | TPH2 | beta-Adrenoceptor (nonspecified subtype) | sigma Receptor (nonspecified subtype) | HTR2A | CALCRL | UGT2B15 | G3569 | LINC02210-CRHR1 | ACKR3 | IGSF9B | MAST4 | SLC6A12 | NTSR1 | KCNJ5 | CRHR1 | NOS2 | CDH2 | TRPA1 | CHRNA3 | NMDA receptor | ADRA1D | PDE2A | G196 | PDE4C | PDE1B | Dopamine receptor (nonspecified subtype) | EPHA4 | HRH1 | SCN9A | ROCK2 | ADCYAP1R1 | HTR6 | L-Type calcium channel (nonspecified subtype) | GAA | BRPF1 | LIN28A | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | TACR1 | AGTR1 | GRM3 | TPH1 | NOX3 | HTR1B | Vasopressin Receptor (nonspecified subtype) | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | CRTC1 | AMPD3 | PROKR1 | TMEM97 | GNAS | TDO2 | GPR171 | ADRB2 | Gastric H+/K+-ATPase | GABRA5 | TH | alpha1-Adrenoceptor (nonspecified subtype) | KCNJ6 | CCKAR | PI4K2A | GRM1 | SSTR5 | GPX4 | NLRP3 Inflammasome | DGKA | Adenosine receptor (nonspecified subtype) | MC4R | SLC6A1 | NPFFR1 | RO60 | NQO2 | PLAU | APP | GABRD | AS3MT | HTR2C | DRD3 | NF-kappaB (NFkB) | ASIC1 | G114548 | G3576 | SLC6A13 | KMT2D | PDE4A | SYNE1 | FTO | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | NADPH Oxidase Complex | THOP1 | P2RX7 | Focal Adhesion Kinases (FAK) (nonspecified subtype) | DAGLA | GABRA2 | Nitric oxide synthase (NOS) (nonspecified subtype) | 5-Hydroxytryptamine Receptor (nonspecified subtype) | ALOX5 | MIR4717 | Histamine Receptor (HR) (nonspecified subtype) | NR1D2 | SLC6A3 | ATXN1 | STX1A | NELL1 | GAD1 | NR1D1 | SSTR1 | G596 | OXTR | Potassium Channels (nonspecified subtype) | IRAK1 | G238 | GRM4 | GPR55 | KCNA1 | MAOB | ADRA1B | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | ANK3 | NR4A2 | RGS1 | CSNK1D | Rho kinase (ROCK) (nonspecified subtype) | NADPH Oxidase (nonspecified subtype) | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | RGS21 | ANPEP | CHRNB2 | RXFP4 | KCNN1 | Gamma-aminobutyric-acid A receptor, Rho | GRIN2B | CHRM2 | RGS2 | REN | ABAT | PDE1A | G7124 | GABRA6 | MCHR1 | Nicotinic alpha3beta2 receptor | NTRK2 | TAAR1 | CRHR2 | MIRLET7 | ODC1 | Glutamate Receptor Ionotropic (nonspecified subtype) | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | IGF2 | SLC1A2 | DAGLB | PDE4D | Melanocortin receptor (nonspecified subtype) | Vasopressin V1 Receptor (nonspecified subtype) | NMUR2 | HTR1D | CTNND2 | STXBP1 | Phosphodiesterase (nonspecified subtype) | Melanin-concentrating hormone (MCH) receptor (nonspecified subtype) | KCNQ2 | MC5R | HDAC6 | CLOCK | ADRA2C | MC1R | HTR7 | ITPR1 | Glutamate Receptor Ionotropic AMPA Receptor | GABRA3 | GABRG1 | G3620 | MIR4761 | Acyl-CoA Synthetase Short-Chain (nonspecified subtype) | cAMP Responsive Element Binding Protein (CREB) (nonspecified subtype) | Monoamine oxidase (MAO) (nonspecified subtype) | AVPR1A | HRH3 | BDNF | HDAC2 | OPRM1 | SCN2A | GABRB1 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | SNCA | DLGAP1 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | KCNIP4 | MIR1307 | TACR3 | CSNK1E | CCK receptor (nonspecified subtype) | PER2 | CDK2 | ACE | OPRK1 | GDNF | PAWR | FFAR4 | CNR2 | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype) | SSTR2 | CACNA1B | CETP | PROKR2 | ELANE | TRPC4 | KDM5B | G4780 | ERCC1

Note: If you'd like to get a target analysis report for Anxiety Disorders, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Anxiety Disorders at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Esophagitis, Eosinophilic | Osteosarcoma | Thyroid Dysgenesis | Reticular Dysgenesis | Growth Hormone Excess | Creatine Deficiency Syndrome | Mucolipidosis Type IV | Hyperkalemic Periodic Paralysis | Kaposiform Hemangioendothelioma | Giant Cell Glioblastoma | Lupus Erythematosus | Nemaline Myopathy 10 | Hereditary Elliptocytosis | Pontocerebellar Hypoplasia | Choriocarcinoma | Tularemia | Keratopathy | Spinocerebellar Ataxia Type 5 | Myelodysplasia | Chronic Kidney Disease | Schizophrenia, Paranoid | Vascular Cognitive Impairment | Spondylosis | Birk-Barel Syndrome | Renal-hepatic-pancreatic Dysplasia | Alzheimer Disease, Late Onset | NGLY1 Deficiency | Aphasia | Weill-Marchesani Syndrome | Ghosal Syndrome | Congestive Heart Failure | Gastroenteritis | Waardenburg Syndrome | Familial Glucocorticoid Deficiency | Infantile Nephropathic Cystinosis | Retinal Detachment | Cardiomyopathy, Dilated, 1L | Poretti-Boltshauser Syndrome | Measles | Spinocerebellar Ataxia Type 13 | Zellweger Syndrome | Argininosuccinic Aciduria | Language Disorders | Osteogenesis Imperfecta | X-linked Myotubular Myopathy | Microtia | MELAS Syndrome | Leiomyosarcoma | Infantile Spasm | Trichorhinophalangeal Syndrome | Herpes Simplex Dermatitis | Multisystemic Smooth Muscle Dysfunction Syndrome | Cannabis Abuse | H Syndrome | Inborn Errors Of Metabolism | Carcinoma, Small Cell | Aplasia Cutis Congenita | Sclerocornea | Connective Tissue Disorders | Schwartz-Jampel-Aberfeld Syndrome | Cartilage Disorders | Pancytopenia | Takayasu's Arteritis | Hyperphenylalaninemia | Mycosis Fungoides | Non-bullous Congenital Ichthyosiform Erythroderma | Skin Fragility-woolly Hair Syndrome | Hypertelorism | Chronic Granulomatous Disease | Bronchitis | Metatropic Dysplasia | Scapuloperoneal Spinal Muscular Atrophy | Neuroblastoma | Cousin Syndrome | Dysmorphophobia | Toxoplasmosis | Epidermolytic Palmoplantar Keratoderma | Chronic Lymphocytic Leukemia | Postpoliomyelitis Syndrome | Hepatorenal Syndrome | Thalassemia, Beta | Pericarditis | Recurrent Respiratory Papillomatosis | Charcot-Marie-Tooth Disease Type 2E | Hemorrhoids | Spasticity | Aspartylglycosaminuria | X-linked Sideroblastic Anemia | Retinal Diseases | Stroke | Hemochromatosis | Uveitis | DOCK8 Immunodeficiency Syndrome | Abetalipoproteinemia | Congenital Nystagmus | Conn Syndrome | Usher Syndrome Type I | Neuronal Ceroid Lipofuscinosis | Aromatic L-amino Acid Decarboxylase Deficiency | Stiff-man Syndrome | Scoliosis | Myocarditis | Familial Hypertrophic Cardiomyopathy | Usher Syndrome | Myelitis, Transverse | Meconium Ileus | Adenoma, Pleomorphic | Schnitzler Syndrome | Glomerulonephritis, Membranous | Graft-versus-host Disease | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Congenital Dyserythropoietic Anemia | Autoimmune Polyendocrinopathy Syndrome Type I | Pheochromocytoma | Lactose Intolerance | Thyroiditis | Thanatophoric Dysplasia Type 1 | Pituitary Dwarfism | Ameloblastic Carcinoma | Histoplasmosis | Autonomic Nervous System Disorders | Hepatitis | Polymicrogyria | Benign Familial Infantile Seizures | Neuroendocrine Cancer | Facioscapulohumeral Muscular Dystrophy | Prader-Willi Syndrome | Extramammary Paget's Disease | Hodgkin Lymphoma | Asphyxia Neonatorum | Choroideremia | Alpha-thalassemia Myelodysplasia Syndrome | Sarcoma, Alveolar Soft Part | Kallmann Syndrome | HANAC Syndrome | Tatton-Brown-Rahman Syndrome | Zimmermann-Laband Syndrome | Pyoderma Gangrenosum | T-cell Prolymphocytic Leukemia | Glioma | Granular Corneal Dystrophy Type 1 | Gliosarcoma | Carcinoma, Squamous Cell | Hemophilia | Stickler Syndrome | Dementia | Hereditary Mixed Polyposis Syndrome | Lymphedema-distichiasis Syndrome | Microphthalmia, Syndromic 7 | Warsaw Breakage Syndrome | Eating Disorder | Stomatitis | Epidermolytic Hyperkeratosis | Epidermolysis Bullosa Simplex | Osteoglophonic Dysplasia | Axenfeld-Rieger Syndrome | Pfeiffer Syndrome | Vaginitis | Usher Syndrome Type III | Multiple Sclerosis | Craniolenticulosutural Dysplasia | Retinitis Pigmentosa | Waardenburg Syndrome Type 2A | Hypotrichosis | Auriculocondylar Syndrome | Oligoastrocytoma | Congenital Generalized Lipodystrophy | Hypertension, Renal | Hypercalciuria | Erysipelas | Cone Dystrophy | Brachydactyly | Progressive External Ophthalmoplegia | Carcinoma In Situ | LMNA-related Congenital Muscular Dystrophy | Epithelial-myoepithelial Carcinoma | Interstitial Lung Diseases | Cutaneous Mastocytosis | Brenner Tumor | Glycogen Storage Disease Type 1b | Hypopituitarism | Fatty Aldehyde Dehydrogenase Deficiency | Hypertensive Retinopathy | Chronic Neutrophilic Leukemia | Jalili Syndrome | IMAGe Syndrome | Multiple Hamartoma Syndrome | Compartment Syndrome | Anencephaly | Neuroma | Alcoholism | Rhabdomyosarcoma, Embryonal | Trichotillomania | Spinocerebellar Ataxia Type 1 | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Congenital Nephrotic Syndrome | Arthrogryposis | Erectile Dysfunction | Craniofacial Dysostosis | AIDS Dementia Complex | Hyperammonemia | Meningococcal Meningitis | Skin Papilloma | Early Infantile Epileptic Encephalopathy 28 | Avian Influenza | Sialidosis | Necrotizing Autoimmune Myopathy | Bacterial Meningitis | Fukuyama Congenital Muscular Dystrophy | Paroxysmal Nocturnal Hemoglobinuria | Distal Myopathy 2 | Rhabdoid Tumor | Tibial Muscular Dystrophy | Synpolydactyly | Hyperparathyroidism-jaw Tumor Syndrome | Nutrition Disorders | Charcot-Marie-Tooth Disease, Type 6 | Atelosteogenesis Type 2 | Leukemia | Nemaline Myopathy | Pearson Syndrome | Autoimmune Polyendocrine Syndrome | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Antisynthetase Syndrome | Major Depression | Clouston Hidrotic Ectodermal Dysplasia | Liver Failure | Menetrier Disease | Macular Degeneration | Persistent Truncus Arteriosus | Dermatitis Herpetiformis | Pure Autonomic Failure | Charcot-Marie-Tooth Disease Type 3 | Adenomyosis | Keratoacanthoma | Liebenberg Syndrome | Neurofibromatosis-Noonan Syndrome | Asplenia | Spinocerebellar Ataxia Type 15 | Carney Triad | Ileitis | Pigment Dispersion Syndrome | C3 Glomerulonephritis | Corneal Neovascularization | Pulmonary Stenosis | Pycnodysostosis | Myotonia | Atherosclerosis | Niemann-Pick Disease, Type A | Congenital Mirror Movements | Arthritis | Non-epidermolytic Palmoplantar Keratoderma | Sezary Syndrome | Hamartoma | Encephalopathy, Glycine | Hypogammaglobulinemia | Sickle Cell Anemia | Pulmonary Veno-occlusive Disease | Glycogen Storage Disease Type 5 | Keratosis | Crigler-Najjar Syndrome | Microphthalmia | Hypotonia-cystinuria Syndrome | Absence Epilepsy | DRESS Syndrome | Pelvic Inflammatory Disease | Mohr-Tranebjaerg Syndrome | Ataxia-ocular Apraxia 2 | Myhre Syndrome | Peroxisomal Disorder | Gastritis, Atrophic | Hereditary Spastic Paraplegia | Amyotrophic Lateral Sclerosis, Juvenile | Erythema Multiforme | Cancer, Bladder | Carcinoid Tumor | Short-chain Acyl-CoA Dehydrogenase Deficiency | Orotic Aciduria | Scleroderma, Diffuse | Chondromyxoid Fibroma | Best Macular Dystrophy | Allan-Herndon-Dudley Syndrome | Treacher Collins Syndrome | Ornithine Transcarbamylase Deficiency | Colorectal Adenoma | Progressive Familial Intrahepatic Cholestasis | Adrenoleukodystrophy, X-linked | Liddle Syndrome | Blepharophimosis Syndrome | Hemolytic Uremic Syndrome | Pulmonary Alveolar Microlithiasis | Seizures-scoliosis-macrocephaly Syndrome | Bronchitis, Chronic | Nephrotic Syndrome | Renal Dysplasia | Hemorrhage | Pituitary Disorders | Sensory Neuropathy | Frontotemporal Dementia | Fowler's Syndrome | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Situs Inversus | Sorsby Fundus Dystrophy | Pemphigus Foliaceus | Bethlem Myopathy | Hypothyroidism | NDH Syndrome | Inflammatory Myofibroblastic Tumor | Progressive Familial Intrahepatic Cholestasis Type 1 | Combined Pituitary Hormone Deficiency | Epidermolysis Bullosa | Generalized Epilepsy And Paroxysmal Dyskinesia | Goldenhar Syndrome | Metaphyseal Chondrodysplasia, Schmid Type | Pneumococcal Meningitis | Leri Pleonosteosis | Lymphoma, AIDS-related | Ovarian Hyperstimulation Syndrome | Chiari Malformation Type I | POEMS Syndrome | Perivascular Epithelioid Cell Tumor | Familial Mediterranean Fever | Joubert Syndrome 2 | SAPHO Syndrome | Autosomal Recessive Bestrophinopathy | Neutropenia | Epilepsy Of Infancy With Migrating Focal Seizures | Phenylketonuria | Leigh Syndrome | Urea Cycle Disorder | Papilledema | Chylothorax, Congenital | Congenital Stationary Night Blindness | Transcobalamin Deficiency | Osteopetrosis | Pneumonia, Mycoplasma | Coffin-Lowry Syndrome | Pneumonia, Viral | Endocarditis | Angiomyolipoma | Paraganglioma, Carotid Body | Empyema | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Sleep Apnea | Pineoblastoma | Bladder Exstrophy | Hypohidrotic Ectodermal Dysplasia | Leri-Weill Dyschondrosteosis | Speech Disorders | Centronuclear Myopathy | Esthesioneuroblastoma | Multiple Sclerosis, Chronic Progressive | Potocki-Shaffer Syndrome | Cryopyrin-associated Periodic Syndromes | Vascular Calcification | Pouchitis | Nijmegen Breakage Syndrome | Blepharitis | 3C Syndrome | Heterotopic Ossification | Peritonitis | Narcolepsy | Kaposi Sarcoma | Syncope | Leukoencephalopathy, Progressive Multifocal | Atrioventricular Septal Defect | Lafora Disease | Adenomatoid Tumor | Diabetes Mellitus, Transient Neonatal | Calcium Pyrophosphate Deposition Disease | Arthritis, Gouty | Diffuse Palmoplantar Keratoderma | Familial Pheochromocytoma-paraganglioma | Methemoglobinemia Type IV | Fragile X Syndrome | Cerebrovascular Disorders | Craniometaphyseal Dysplasia | Diabetes Insipidus | Mucolipidosis Type III | Retinitis | Charcot-Marie-Tooth Disease | Dementia, Vascular | Platelet Disorders | Heart Failure | Peutz-Jeghers Syndrome | Wolman Disease | Glioblastoma Multiforme | Astigmatism | Hyperinsulinemic Hypoglycemia | Vitamin K Deficiency | Erythrokeratodermia Variabilis | Bloom Syndrome | Sensorineural Hearing Loss | Barakat Syndrome | Alveolar Capillary Dysplasia | Mastitis | Neurodevelopmental Disorders | Rhabdomyosarcoma, Alveolar | Basan Syndrome | Infantile Liver Failure Syndrome 1