Graft-versus-host Disease

About the Disease
Graft-Versus-Host Disease, also known as graft-versus-host disease, susceptibility to, is related to bronchiolitis obliterans and acute graft versus host disease. An important gene associated with Graft-Versus-Host Disease is IL10 (Interleukin 10), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Tacrolimus and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone marrow and t cells, and related phenotypes are elevated hepatic transaminase and skin erosion

Common Targets
CD74 | ICAM1 | Lysophospholipid (edg) Receptors (nonspecified subtype) | TRPV2 | LOC105375139 | FLT3 | ORAI1 | CD247 | LAG3 | C-C chemokine receptor (nonspecified subtype) | PPP3R2 | HDAC3 | DHODH | TNFRSF25 | SDAD1-AS1 | CD6 | DNA-Directed RNA Polymerase (nonspecified subtype) | NPM1 | SYK | DPP4 | PRMT5 | G6352 | PPP3CC | BRD2 | TLR2 | Hedgehog Protein (nonspecified subtype) | BSG | NOD2 | GSK3B | GSTT1 | G3605 | CD40 | SELL | PTCH1 | SUFU | BMX | VKORC1 | IL-1 Receptor (nonspecified subtype) | CTLA4 | LOC728392 | PPID | LOC102724428 | DAAM2 | HLA-G | IL7R | CTPS1 | Integrin alpha4beta7 (LPAM-1) receptor | SERPINE1 | CD83 | ARG1 | TNFSF13B | CD38 | IL1RL1 | ATP Synthase, H+ Transporting, Mitochondrial F0 complex | JAK2 | PDGFRA | S1PR4 | KIT | CD86 | CCR7 | HSF1 | S1PR2 | SELP | IL-2 receptor | NFKBIA | TLR9 | DCK | RAF1 | ATP5IF1 | MASP2 | MS4A1 | HDAC11 | TRPA1 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | IFNG | G673 | CMC2 | IL34 | LOC105377795 | Interleukin-12 (IL-12) | IL2 | ITK | JAK3 | FGFR4 | ADA | G7099 | G114548 | JAK1 | IL1A | S1PR3 | CYP3A5 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | IL10RB | IMPDH1 | Proteasome Complex | CRBN | Adenosine deaminase (nonspecified subtype) | NLRP3 Inflammasome | Histone deacetylase (nonspecified subtype) | FASLG | ITGA4 | SLC16A1 | CD48 | CCR5 | HLA-DPA1 | CD52 | ROCK2 | MTHFD2 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | GSTM1 | MGMT | FCRL3 | Serine protease (nonspecified subtype) | PTGDR2 | TGFB1 | PECAM1 | PLAT | IL5 | CXCR3 | CD8 | G196 | BLK | G5133 | UGT1A9 | G920 | IL4 | CYP1A2 | GLCCI1 | HLA-DQB1 | G9734 | ABL1 | PIM1 | CD80 | RFC1 | PTPN22 | SIK2 | MIR146A | AZIN1 | LHCGR | CD7 | G596 | FPR2 | Immunoproteasome | GPR55 | PPP3CB | IL6R | SELPLG | S1PR5 | ITLN1 | Integrin alphaLbeta2 (LFA-1) receptor | BRD3 | EDN1 | PPP3R1 | CSF2 | LOC105378206 | HLA-DPB1 | FAS | IL13 | G6774 | HLA-C | FGFR2 | PDGFRB | STING1 | G2475 | AKR1A1 | UGT2B17 | G238 | HLA-DRB1 | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | G2146 | G3146 | CSF1R | DHFR | HAVCR2 | TCIRG1 | CD19 | ALB | SIK1 | S1PR1 | G5243 | TNFRSF4 | TLR7 | TNFRSF17 | BTLA | PRKCQ | LOC105374527 | HIF1A | CASP1 | Uncharacterized LOC105371833, transcript variant X2 | BTK | HPSE | Glutaminase (nonspecified subtype) | G1956 | CD28 | TGFBR2 | CXCL10 | REG3A | PSMB8 | MTHFR | IRAK1 | ELANE | GLP2R | IL18 | HDAC2 | HCAR2 | G7124 | FUT2 | IL21 | IL23R | TLR6 | CYP1B1 | NFKB1 | ABO | LOC105378657 | HLA-B | Mitochondrial pyruvate carrier complex (MPC) | TNFRSF8 | BCL6 | IL1RN | AURKA | NR3C1 | PTPRC | CD79B | IL18R1 | LIG1 | FOXP3 | CD276 | AOC3 | MICA | CDK2 | CD3 Complex (T Cell Receptor Complex) | GSPT1 | LGALS1 | RORC | G3569 | RNF111 | TBK1 | CYP3A4 | FGFR3 | MADCAM1 | Protein Phosphatase 2B | ITPKB | THRA | TRPV1 | CCL24 | TYK2 | TLR8 | G925 | IL12B | PPIA | G142 | TRPM8 | PIK3CD | THBD | VSIR | CYP2C19 | Protein kinase C (nonspecified subtype) | TLR1 | ACHE | SELE | SIK3 | IL2RB | G3630 | SDAD1 | SMO | HDAC1 | IL22RA1 | RIPK2 | Interleukin 17 (nonspecified subtype) | BRD4 | G9429 | C5 | VDR | APEH | IL1B | Interleukin-7 receptor | Alpha-2 Adrenergic receptors (nonspecified subtype) | KIR2DS4 | CAMKK2 | CXCL11 | INPP5D | FGFR1 | TNFSF4 | CD40LG | FKBP1A | IL2RA | GLCCI1-DT | GSK3A | Protein Phosphatase 2A | FCGR2B | ICOS | KCNA3 | NCR2 | Integrin alpha4beta1 (VLA-4) receptor | TRBC2 | KLRC1 | MALT1 | HMGCR | Folate Receptor (nonspecified subtype) | G1432 | HDAC10 | ART3 | ROCK1 | BCR | TEC | ATP synthase, H+ transporting, mitochondrial F1 complex | PADI4 | IL10 | STAT6 | DNASE1 | PSMB5 | IL-15 receptor | PF4 | HLA-A | LCK | PGR | CCR10 | CXCL9

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