DiGeorge Syndrome

About the Disease
Chromosome 22q11.2 Deletion Syndrome, Distal, also known as 22q11.2 deletion syndrome, is related to digeorge syndrome and velocardiofacial syndrome. An important gene associated with Chromosome 22q11.2 Deletion Syndrome, Distal is TBX1 (T-Box Transcription Factor 1), and among its related pathways/superpathways is 22q11.2 copy number variation syndrome. The drugs Risperidone and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and thymus, and related phenotypes are intellectual disability and global developmental delay

Common Targets
WDR74 | THAP7-AS1 | ASXL1 | SNX12 | UFD1 | SHANK3 | FBN1 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | ZFC3H1 | H4C8 | AP2S1 | TBX1 | TRPM8 | ZNF595 | SMARCA2 | IL17RA | Gamma-Aminobutyric acid type B receptor | PRMT5 | H2AC21 | COMT | H4C9 | SNX5 | CLIC6 | LOC653513 | CRKL | MRGPRF | SNX16 | SGO1-AS1 | GOLM2 | HNRNPC | TRPV2 | CLTCL1 | SLC15A3 | TIAM1 | EIF3F | IQSEC1 | H2BC21 | HES7 | LOC105375928 | PRODH | ABCB9 | IQCG | PRMT5-DT | RNU6-2 | RPL7A | JAG1 | ARVCF | ADNP2 | H2BC12 | LOC105371522 | PHC1 | SETD2 | PDE4DIP | SGO1 | HDAC4 | LOC105374377 | H2AC4 | H2AC20 | ZFPM2 | H3C3 | ANG | EP400 | CEP76 | MGME1 | RNASE4 | RPL35A | RDH10 | LOC105369835 | SALL4 | TAGLN2 | AGBL2 | SLC7A2 | DGCR2 | MED22 | LASP1 | SPECC1L | GPR55 | ARLNC1 | DNAJB4 | SNORD36B | CHEK2 | SNORD36A | LINC03055 | LOC105374903 | SNORD24 | ARSA | GNB1L | LOC105374985 | RNU2-2P | THAP7 | P2RX6 | CTTN | H3C2 | OGFOD2 | H2BC3 | G3308 | H4C1 | G595 | GAB1 | RPL7 | TMEM259 | SHF | SKI

Note: If you'd like to get a target analysis report for DiGeorge Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of DiGeorge Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Hypotonia-cystinuria Syndrome | Vitelliform Macular Dystrophy | Cholera | Hypobetalipoproteinemias | Pathological Gambling | Pneumothorax | Milk Allergy | Spinocerebellar Ataxia Type 27 | Retinoschisis | Primrose Syndrome | Ocular Surface Squamous Neoplasia | Von Hippel-Lindau Disease | Hyperparathyroidism | Hepatitis | Colorectal Adenoma | LRBA Deficiency | Hypertension, Essential | Myotonic Disorders | Compartment Syndrome | Hyperekplexia | Craniofrontonasal Syndrome | Cholesteryl Ester Storage Disease | Barakat Syndrome | Granular Corneal Dystrophy | Hypocalcemia | Hypertension, Portal | Renal Oncocytoma | Aplastic Anemia | Diastrophic Dysplasia | Enterocolitis, Necrotizing | Polymyalgia Rheumatica | Chondroma | Gastrointestinal Disorders | Lichen Sclerosus | Hepatitis A | Batten Disease | DRESS Syndrome | Hepatitis, Autoimmune | Neuronal Ceroid Lipofuscinosis | Vitreoretinal Degeneration, Snowflake Type | Liddle Syndrome | Glycogen Storage Disease Type 6 | Anti-NMDA Receptor Encephalitis | Hypopituitarism | Thrombophilia | Adenoma, Pituitary | Echinococcosis | Distal Myopathy 2 | Chudley-McCullough Syndrome | Progressive Familial Intrahepatic Cholestasis | Fundus Albipunctatus | Esophageal Motility Disorders | Kabuki Syndrome 2 | Hyperlipidemia, Familial Combined | Chronic Neutrophilic Leukemia | Polymicrogyria | Disseminated Superficial Actinic Porokeratosis | Charcot-Marie-Tooth Disease, Type 2C | Heterotopic Ossification | Polycythemia Vera | Leukocyte Adhesion Deficiency | Neuromyelitis Optica | MELAS Syndrome | Inflammatory Myopathy | Intestinal Pseudo-obstruction | Transthyretin-related Amyloidosis | Metabolic Diseases | Osmotic Demyelination Syndrome | Facioscapulohumeral Muscular Dystrophy | Tinea | Aldosterone Deficiency | Anencephaly | Cutaneous Lupus Erythematosus | Niemann-Pick Disease, Type C | Chylomicron Retention Disease | Gaucher Disease | Cervicitis | Pituitary Dwarfism | Waardenburg Syndrome Type 2E | Conjunctivitis, Allergic | Down Syndrome | Cherubism | Chromosome 5q Deletion Syndrome | Brachydactyly | Lipoma | Primary Hyperoxaluria | Nijmegen Breakage Syndrome | Dent Disease | Bulimia Nervosa | Periodontitis | Dermatofibrosarcoma | Lymphoma | Paraplegia | Lymphoproliferative Disease, X-linked | Neurocysticercosis | NDH Syndrome | Hemolytic Uremic Syndrome | Endophthalmitis | Neuromuscular Disorders | Skin Carcinoma | Aceruloplasminemia | Guillain-Barre Syndrome | Nicolaides-Baraitser Syndrome | Amyotrophic Lateral Sclerosis, Juvenile | Pelizaeus-Merzbacher Disease | Dysmorphophobia | Mucolipidosis | Malonyl-CoA Decarboxylase Deficiency | Acute Leukemia | Cryptosporidiosis | Spinocerebellar Ataxia Type 42 | Pigment Dispersion Syndrome | Heterotaxy | Von Willebrand Disease | Anorchia | Nail Disorder, Nonsyndromic Congenital | Pancytopenia | C3 Glomerulonephritis | Phenylketonuria | Analgesia | Mohr-Tranebjaerg Syndrome | Autism Spectrum Disorders | Pontocerebellar Hypoplasia Type 7 | Camurati-Engelmann Disease | Pyoderma Gangrenosum | Neuroendocrine Cancer | Keratoacanthoma | Adenomyosis | Purpura, Thrombotic Thrombocytopenic | Eosinophilic Asthma | High Molecular Weight Kininogen Deficiency | Cancer, Brain | Crisponi Syndrome | Lentigo | Premenstrual Syndrome | Trichomegaly | Twin-to-twin Transfusion Syndrome | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Cutis Laxa | Eating Disorder | Panuveitis | Tinea Versicolor | Hidradenitis | Sclerosteosis 2 | Ichthyosis Hystrix, Curth-Macklin Type | Necrobiosis Lipoidica | Congenital Nystagmus | Pyruvate Carboxylase Deficiency Disease | Arthrogryposis | Heart Block | Sick Sinus Syndrome 1 | Porphyria | Ehlers-Danlos Syndrome | Nance-Horan Syndrome | Hemorrhoids | Malignant Peripheral Nerve Sheath Tumor | Otitis Externa | Mood Disorder | Diabetes Gestational | Loeys-Dietz Syndrome Type 4 | Hemangioblastoma | Ameloblastic Carcinoma | Nephrotic Syndrome Type 1 | Pouchitis | Histiocytosis | Keratosis, Seborrheic | Hyperuricemic Nephropathy, Familial Juvenile | Amelogenesis Imperfecta | Wolcott-Rallison Syndrome | Paroxysmal Nocturnal Hemoglobinuria | Mitochondrial Cytopathy | Early Infantile Epileptic Encephalopathy 28 | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Lateral Meningocele Syndrome | Epilepsy, Generalized | Infectious Diarrhea | Sarcosinemia | Pitt-Hopkins Syndrome | Cancer, Skin | Muckle-Wells Syndrome | Basan Syndrome | Non-bullous Congenital Ichthyosiform Erythroderma | Dental Caries | Primary Torsion Dystonia | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Congenital Hereditary Endothelial Dystrophy Type I | Brenner Tumor | Dermatitis | Acute Lung Injury | Giant Cell Glioblastoma | Allergic Contact Dermatitis | Congenital Afibrinogenemia | Juvenile Polyposis | Diabetes Insipidus, Neurogenic | Nephroblastoma | Miyoshi Myopathy | Avian Influenza | Usher Syndrome Type I | Pyelonephritis | Metatropic Dysplasia | Diabetic Nephropathy | Chronic Myeloid Leukemia | Autonomic Neuropathy | Diabetes Insipidus | Papilledema | Spondylocostal Dysostosis | Esthesioneuroblastoma | Williams Syndrome | Glaucomatocyclitic Crisis | Leiomyosarcoma | Pulmonary Alveolar Proteinosis | Alpers Syndrome | Alopecia Totalis | Tonsillitis | Leri-Weill Dyschondrosteosis | Vogt-Koyanagi-Harada Syndrome | Urethritis | Enhanced S-cone Syndrome | Sezary Syndrome | Postpoliomyelitis Syndrome | Sensorineural Hearing Loss | Cystitis | Atelosteogenesis Type 1 | Nephrotic Syndrome | Fetal Akinesia Deformation Sequence | Protein S Deficiency | Wolman Disease | Spinocerebellar Ataxia Type 31 | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Inborn Errors Of Metabolism | Congenital Adrenal Hyperplasia | Beckwith-Wiedemann Syndrome | Nutrition Disorders | Malaria, Cerebral | Overactive Bladder | Dengue Hemorrhagic Fever | Meningioma | Insulinoma | Communication Disorders | Lafora Disease | Goldenhar Syndrome | Sotos Syndrome | Cutaneous Mastocytosis | Ectodermal Dysplasia | Whipple's Disease | Congenital Generalized Lipodystrophy | Deafness, Dystonia, And Cerebral Hypomyelination | Double Outlet Right Ventricle | Cluster Headache | Autoimmune Autonomic Ganglionopathy | Creatine Deficiency Syndrome | Encephalopathy, Hepatic | Prune Belly Syndrome | Genee-Wiedemann Syndrome | Nicotine Addiction | Waardenburg Syndrome Type 4A | Acrodermatitis | Medulloblastoma | Uveitis | Phenylketonuria II | Melanoma | Fragile X Syndrome | T-cell Prolymphocytic Leukemia | Antithrombin III Deficiency | Basal Ganglia Disease, Biotin-responsive | Aspergillosis | Jawad Syndrome | Diabetic Encephalopathy | Nager Acrofacial Dysostosis | Cataract | Glutaric Aciduria Type 1 | HUPRA Syndrome | Spinocerebellar Ataxia Type 5 | Malnutrition | Bicuspid Aortic Valve | Strabismus | Crimean-Congo Hemorrhagic Fever | Mesothelioma, Malignant | Amblyopia | Lymphangiomatosis | Epilepsy | CEDNIK Syndrome | Multiple System Atrophy | Polycythemia | Autoimmune Polyendocrine Syndrome | Juvenile Hyaline Fibromatosis | Sleep Apnea | Oligodendroglioma | Glycogen Storage Disease Type 5 | Congenital Adrenal Hyperplasia 1 | Bloom Syndrome | Polycystic Ovary Syndrome | Hypophosphatasia | Adrenoleukodystrophy, X-linked | Long QT Syndrome Type 1 | Chediak-Higashi Syndrome | Usher Syndrome | Myelodysplasia | Alpha-1 Antitrypsin Deficiency | Chronic Inflammatory Demyelinating Polyneuropathy | DOCK8 Immunodeficiency Syndrome | Extramammary Paget's Disease | Imerslund-Grasbeck Syndrome | Prolidase Deficiency | Sarcomatoid Carcinoma Of The Lung | Hepatitis E | Papulopustular Rosacea | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Canavan Disease | Ameloblastoma | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Thyroid Dyshormonogenesis | Hyperlipidemia Type V | Bruck Syndrome | Raynaud Phenomenon | Glaucoma | Angioedema, Hereditary | Premature Ejaculation | Desbuquois Syndrome | Hepatitis B, Chronic | Chronic Leukemia | Adenoma, Pleomorphic | Schindler Disease | Hereditary Spastic Paraplegia | Marinesco-Sjogren Syndrome | Central Retinal Artery Occlusion | Infantile Neuroaxonal Dystrophy | Idiopathic Pulmonary Fibrosis | Osteoporosis, Postmenopausal | Usher Syndrome Type IIC | Long QT Syndrome Type 3 | Autosomal Recessive Congenital Ichthyosis | Bethlem Myopathy | Diabetes | CREST Syndrome | Macrophage Activation Syndrome | Albinism | Rash | Fowler's Syndrome | Joubert Syndrome | Sarcoma, Ewing | Hepatic Adenomatosis | Large Granular Lymphocytic Leukemia | Alopecia Areata | Anti-glomerular Basement Membrane Disease | Meier-Gorlin Syndrome | Schizotypal Personality Disorder | Myoclonic Epilepsy With Ragged Red Fibers | Anxiety Disorders | Pantothenate Kinase-associated Neurodegeneration | X-linked Myotubular Myopathy | Lewy Body Dementia | Costello Syndrome | Membranous Nephropathy | Fibromuscular Dysplasia | Meleda Disease | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Lymphedema | Currarino Syndrome | Eclampsia | Erythrokeratodermia Variabilis | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Gangliosidosis | Neurofibromatosis | Prader-Willi Syndrome | Cutaneous T-cell Lymphoma | Lysosomal Acid Lipase Deficiency | Sarcoma, Alveolar Soft Part | Oculocutaneous Albinism | Alstrom Syndrome | Tracheal Disorders | Endometritis | Familial Male-limited Precocious Puberty | Hypertrophy | Fibromyalgia | Pleurisy | VACTERL Association | Uremia | Ichthyosis | Hereditary Pyropoikilocytosis | Torticollis | Infantile Spasm | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Metaphyseal Chondrodysplasia, Schmid Type | Parvovirus B19 Infection | Erythromelalgia | Cushing Syndrome | Addison Disease | Encephalitis | McLeod Syndrome | Dysthymia | Posterior Polar Cataract | Keratitis | Heavy Chain Disease | Olmsted Syndrome | Occipital Neuralgia | Gerstmann-Straussler-Scheinker Syndrome | Desmosterolosis | Giant Cell Arteritis