Glaucoma

About the Disease
Intraocular Pressure Quantitative Trait Locus, also known as glaucoma, is related to primary angle-closure glaucoma and open-angle glaucoma. An important gene associated with Intraocular Pressure Quantitative Trait Locus is ZEB1 (Zinc Finger E-Box Binding Homeobox 1), and among its related pathways/superpathways are Clear cell renal cell carcinoma pathways and BMP signaling in eyelid development. The drugs Topiramate and Bromfenac have been mentioned in the context of this disorder. Affiliated tissues include Eye, retina and bone marrow, and related phenotypes are homeostasis/metabolism and nervous system

Common Targets
Superoxide dismutase (SOD) (nonspecified subtype) | NADPH Oxidase (nonspecified subtype) | ADRA2C | HSP90B1 | ALOX15 | G7124 | GPR55 | MMP1 | MMP16 | G5243 | G7422 | HTR7 | MYLK4 | G6647 | COX2 | HRH3 | RNR1 | Prostaglandin EP Receptor (nonspecified subtype) | Lysophospholipid (edg) Receptors (nonspecified subtype) | MAP3K12 | P2RY1 | ENPP2 | CSNK1E | INPPL1 | EDNRA | G114548 | JAK3 | NTRK2 | PDE4D | JAK1 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | G5599 | cAMP Phosphodiesterase (nonspecified subtype) | G6714 | MINK1 | TAFA5 | Prostanoid Receptor (nonspecified subtype) | m-Calpain | SOS2 | CNIH4 | RNR2 | Calpain (nonspecified subtype) | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | IFNB1 | KDR | NGFR | CRBN | ADAMTS10 | PTGES | GLIS1 | Carbonic Anhydrase (nonspecified subtype) | CA5A | G1956 | SLC18A2 | MC1R | ABL1 | GBA1 | LIMK1 | TNFRSF1B | gamma-Secretase | COX3 | Rho GTPase (nonspecified subtype) | KISS1 | GRM5 | JAK2 | Serine/Threonine Kinase (nonspecified subtype) | IL1B | SRF | LRRK2 | Geranylgeranyl transferase type-1 | PTGER3 | MTNR1A | CHRM4 | Tyrosine-Protein Kinases Src (nonspecified subtype) | THRB | cGMP-Dependent Protein Kinase (nonspecified subtype) | OPRK1 | ADRA1A | PRKCG | ADRA2B | HDAC6 | TXNRD2 | MGLL | G3620 | Thyroid hormone receptor (nonspecified subtype) | HDAC2 | LIMK2 | GPR18 | beta-Secretase (nonspecified subtype) | CA6 | G3569 | GRK3 | Heat shock protein 90 (nonspecified subtype) | TAFA1 | YWHAG | OPRM1 | ROCK1 | BTK | CA1 | MYOC | Alpha-2 Adrenergic receptors (nonspecified subtype) | CA12 | CNR2 | ND1 | TNIK | SIGMAR1 | Mucin (nonspecified subtype) | SORT1 | ACE | CHRM1 | FKBP1A | Transforming growth factor (nonspecified subtype) | PPARA | Calcium channel (nonspecified subtype) | CYTB | SLC22A12 | G1432 | BMX | DBH | TJP1 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | CDKN2B | TYR | SIX6 | P2RY6 | S1PR2 | mTOR complex 1 | BMP1 | Protein kinase C (nonspecified subtype) | GAS1RR | G7099 | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | TYK2 | SGK2 | CDK5 | HSF1 | ADORA1 | NF-kappaB (NFkB) | ADORA2B | KCNN4 | Neurotrophic Factor (nonspecified subtype) | Myosin Class II (nonspecified subtype) | PANX1 | PDE6C | alpha-Adrenoceptor (nonspecified subtype) | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | TRPM8 | Adenylate Cyclase (nonspecified subtype) | G4780 | HMGCR | PIEZO1 | Chloride channel (nonspecified subtype) | HTR2B | HTR1A | ND2 | CA13 | LINGO1 | LOXL1-AS1 | KIT | DRD2 | Nicotinic alpha4beta2 receptor | CA7 | TMTC2 | ABCA1 | G7852 | DDAH1 | PLEKHA7 | PMEL | BCHE | G4137 | CDKN2B-AS1 | CNR1 | MTNR1B | PGR | Estrogen receptor (nonspecified subtype) | ANGPT2 | cAMP-Dependent protein kinase (PKA) | TRPV2 | ADRA2A | S1PR3 | TIE1 | SMURF1 | CASP2 | PRKCH | MAP4K4 | LOXL1 | LCP2 | Na+/K+-ATPase (nonspecified subtype) | HSD11B1 | PPARD | MYH2 | DDIT4 | ND3 | G581 | 15-Lipoxygenase (nonspecified subtype) | GREM1 | AKR1B1 | PRKCD | K(ATP) Channel (nonspecified subtype) | ADORA2A | SSTR4 | Tyrosine Kinase (nonspecified subtype) | PDGFRB | IL1R1 | TRPV1 | BACE1 | Voltage-Gated Sodium Channel Complex | SRBD1 | PTGDR | LRRN1 | ADORA3 | ADRB1 | OPRD1 | CASP8 | MME | PTGS1 | ACHE | CHRM3 | CAPN1 | Prostanoid TP receptor (nonspecified subtype) | beta-Adrenoceptor (nonspecified subtype) | KCNA7 | LRP1 | DRD1 | GSK3B | LRRC4 | NTRK1 | ANGPTL7 | PTGER4 | LTBP2 | OGA | PDE1B | TRPM7 | ACMSD | G2475 | ND4 | Actin (nonspecified subtype) | EDN1 | SLC1A1 | Integrin alphaLbeta2 (LFA-1) receptor | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | FAAH | MYLK | MMP13 | G3630 | ENPEP | Carbonic Anhydrase V (nonspecified subtype) | TLL1 | Sodium channel (nonspecified subtype) | HTR6 | TGFB2 | GRK5 | CA14 | G836 | Mitogen-Activated Protein Kinase (nonspecified subtype) | FPR2 | PTGER1 | Cannabinoid receptor (nonspecified subtype) | NQO2 | TMEM97 | Adenosine receptor (nonspecified subtype) | ATP6 | FLT1 | BLK | TEK | G4318 | MAPK10 | TLL2 | VCP | CA2 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | SLCO2A1 | NOS3 | CA9 | DDR1 | P2RY14 | G7157 | PLA2G7 | ROCK2 | PGF | SCN9A | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | Aurora Kinase (nonspecified subtype) | COL11A1 | ADRB2 | MMP8 | OPA1 | CA5B | alpha1-Adrenoceptor (nonspecified subtype) | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | CAV2 | NR3C1 | SEMA3A | GAA | ATP8 | NOX3 | Endothelin receptor (nonspecified subtype) | IL2 | NMDA receptor | LRP2 | LYN | AGTR2 | PDE5A | APP | AGTR1 | Imidazoline I3 receptor (I3) | 5-Hydroxytryptamine Receptor (nonspecified subtype) | ND5 | NT5E | MMP2 | NAMPT | ADRA1B | alpha-Amylase (nonspecified subtype) | AQP1 | Tubulin | CA3 | FOXC1 | PKN2 | G367 | GRK2 | NOS2 | P2RX7 | KRR1 | HTR2C | GRN | HTR2A | MMP14 | TRPA1 | MRTFA | CYP1B1 | PDE1A | TBK1 | PTGFR | IFNG | REN | G5743 | NADPH Oxidase Complex | CHRNB2 | Bradykinin receptor (nonspecified subtype) | NPR2 | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | Rho kinase (ROCK) (nonspecified subtype) | IRS1 | Potassium Channels (nonspecified subtype) | PRKG1 | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | SLC1A2 | FOXE3 | IKBKE | NTF4 | PRKN | RIPK1 | HTR1D | COX1 | SLC6A5 | S1PR1 | MC5R | MAOB | CHRM2 | DHFR | mu-Calpain (calpain 1) | INPP5D | RHOA | Soluble guanylyl cyclase | ND6 | CAPN2 | PTGER2 | MTHFR | NGF | FLT3 | KISS1R | Histone deacetylase (nonspecified subtype) | ADAR | IL10 | CA4 | PITX2 | CYP19A1

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