Coronary Artery Disease

About the Disease
Coronary Heart Disease 1, also known as coronary heart disease, is related to angina pectoris and abdominal obesity-metabolic syndrome 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Coronary Heart Disease 1 is CX3CR1 (C-X3-C Motif Chemokine Receptor 1), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Simvastatin and Lovastatin have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Increased free cholesterol and Increased LDL uptake

Common Targets
SLC9A1 | PF4 | MRGPRX1 | AMPD1 | HLA-DQA1 | PADI4 | CNR1 | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | gamma-Secretase | PRDX1 | KCNN3 | MAP1A | APOM | MIR4432HG | EPHX2 | C5 | P2RY1 | MAS1L | IKBKB | IL2RA | LPAR2 | TOMM40 | AXL | G59272 | G142 | Lysophospholipid (edg) Receptors (nonspecified subtype) | ESR2 | FADS2 | TRIM14 | HAMP | MAOA | TRAF1 | P2RX1 | BUD13 | NR1H2 | FUT6 | PIK3CD | HTR1A | SHISA6 | LINC00824 | SLC29A2 | SLC7A9 | ADAMTS7 | TRPV1 | FKBP1A | ARHGEF26-AS1 | ITGA1 | NGFR | TAF1A-AS1 | CCR6 | MTHFR | NR3C1 | G2099 | ANGPTL4 | IL37 | PRC1 | APOA2 | Calpain (nonspecified subtype) | ROCK1 | Folate Receptor (nonspecified subtype) | SREBF2 | LTA | AGT | ALDH2 | MMUT | BRD4 | PNPLA3 | ALOX5AP | LOC340184 | TYR | G1432 | MMP3 | F13A1 | TNPO3 | DGAT1 | ZPR1 | G5243 | GNB3 | NAT2 | PTGER3 | SLC12A3 | SMG6 | EOMES | UBE2Q2 | ADIPOQ | PTGS1 | BMAL1 | MAP2K1 | ADRA2B | KCNJ13 | MADD | PTGIR | TMEM91 | CYP7A1 | G7295 | TRNT | GJA4 | CDKN2B | RAI1 | HMGCR | KEAP1 | MAP3K5 | CASR | LOC101928923 | TIMD4 | ADAMTS13 | Estrogen receptor (nonspecified subtype) | FEN1 | UBR5 | ARHGEF26 | C14orf39 | DAB1 | ACHE | LINC02398 | MCU | IL4R | CPS1 | T-Type Calcium Channel | ABCD4 | GABA(A) receptor | WARS1 | G5743 | UGT2A2 | ADORA1 | APLNR | VIM | APOA4 | mTOR complex 1 | G23411 | G6PC2 | MIR1908 | CERT1 | G9429 | HTR2B | ICAM1 | APOA5 | Cyclin-dependent kinase (nonspecified subtype) | IL6-AS1 | ABCC5 | G5594 | Glycogen phosphorylase (nonspecified subtype) | COL4A1 | DNA Topoisomerase II (nonspecified subtype) | Tubulin | XPNPEP1 | F11R | ITGA2 | CTSS | PPP3R2 | G4609 | JCAD | Matrix Metalloproteinase (MMP) (nonspecified subtype) | Thyroid hormone receptor (nonspecified subtype) | NPC1L1 | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | Voltage-Gated Sodium Channel Complex | DAB2 | Phospholipase A2 (nonspecified subtype) | VKORC1 | NR1H3 | LINC02702 | CDK5 | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | CYP1A1 | AHCY | XPNPEP2 | ADORA2B | FDFT1 | TGFBRAP1 | SFXN2 | CCR4 | SCD | AQP4 | FLT1 | ZDHHC22 | G3630 | VDR | ANKS1A | TNFSF11 | GP1BA | Ephrin Receptor (nonspecified subtype) | TRPM6 | G4318 | MMP12 | IRS2 | CDKAL1 | NOD2 | HSD11B1 | SUGP1 | DYRK1A | DGAT2 | PPP3CC | PAR Receptor (nonspecified subtype) | THBS2 | TRRAP | KALRN | LOC105370913 | ENG | F2 | TMEM163 | CDKN2B-AS1 | CD14 | MIR155 | TGFBR1 | SLC22A12 | Relaxin receptor (nonspecified subtype) | SLC22A3 | LOX | CCR2 | ATP1B1 | OGG1 | CASP8 | Integrin Receptor (nonspecified subtype) | ADORA2A | Serine palmitoyltransferase | MTRR | CAMTA1 | ANGPTL3 | PROCR | ABCA1 | PALLD | PKLR | SLC17A3 | Sodium channel (nonspecified subtype) | DPP4 | F3 | F10 | NOTCH4 | SLC14A1 | PLCL2 | ADTRP | SCARB1 | ARG1 | COQ8B | EBI3 | LOC107987407 | CCR7 | KDR | SOD2 | LPP | ADAM17 | CCDC92 | ADAMTS5 | ENTPD1-AS1 | CDK9 | GSTT1 | G3605 | SNRPD2 | UBE2E2 | XDH | LOC105375716 | CD40 | ABCG1 | SORT1 | NOS3 | AKR1B1 | NOX4 | PPARD | IL1RL1 | PTPN1 | Tyrosine Kinase (nonspecified subtype) | FLACC1 | EHF | GJA5 | CXCR1 | LINC00261 | PCNX3 | PCSK9 | Cholesterol esterase (nonspecified subtype) | MAP3K14 | AVPR2 | ROS1 | G367 | C12orf43 | MLXIPL | CD320 | MIR34B | FES | PIP5K1B | ANGPT2 | GSK3B | Opioid receptor (nonspecified subtype) | TMPRSS6 | ACAD10 | ATP5IF1 | NFKBIA | LOC105375733 | ATG5 | Guanylate cyclase (nonspecified subtype) | BCHE | IL10 | RPSAP52 | Reverse transcriptase (Telomerase) | ADRA2A | SERPINE1 | PGAM5-KEAP1-NRF2 Complex | ADRB3 | SMPD1 | ALPK1 | PHB1 | HTRA1 | Oxysterols receptor LXR (nonspecified subtype) | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | VCAM1 | GPX1 | LOC105375745 | SHROOM3 | UBE2Z | SELP | CLYBL | NPY2R | G836 | ADIPOQ-AS1 | LIPA | PINX1 | IL1B | LPAL2 | CFDP1 | G5595 | APOC3 | RNF213 | REL | FGA | ANK1 | STRADA | VAMP5 | G3569 | MTNR1B | POM121L9P | IL15 | CYP24A1 | LY75 | TCF21 | MMP2 | OPRD1 | CES1 | DACH1 | MEF2A | PLTP | SMARCA4 | ZFHX3 | ARID5B | TM6SF2 | DNMT3B | SBF2 | ELP1 | GPR146 | XRCC3 | UTS2R | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | ERCC2 | PRKAG2 | MMEL1 | GRM7 | ADD1 | Integrin alphavbeta5 receptor | Mitogen-Activated Protein Kinase (nonspecified subtype) | ADORA3 | HHIPL1 | GCKR | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | S1PR3 | EHBP1 | ADA | MIR3936HG | RYR2 | PLG | DDX59-AS1 | PSMA6 | HTR2A | PBX2 | SHC1 | SLC44A2 | TDRKH | ADH1B | MYH15 | SNX19 | PSRC1 | CTLA4 | ADRB1 | G7422 | C7orf50 | C1QL4 | MIR34C | TNKS2 | MTHFD1L | CLEC4C | IL27 | K(ATP) Channel (nonspecified subtype) | DCLK2 | MME | ATP2B1 | PENK | TRPC6 | FGFR4 | PECAM1 | ARAP1 | CXCL12 | CYP3A5 | TCTA | ANGPTL8 | LOC105375920 | STAT4 | TEK | TSPO | CCL11 | CELSR2 | CAV1 | ADCY5 | 15-Lipoxygenase (nonspecified subtype) | Sphingomyelin phosphodiesterase (nonspecified subtype) | IL1A | TCN1 | P2RX4 | PRKCD | CYP2R1 | TLR9 | NPPA-AS1 | LINC01104 | IL2 | SPSB4 | ABCC8 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | USF1 | FLOT2 | POLK | MPG | SIDT2 | NRP1 | NDUFAF6 | TBX2 | AGTR1 | G7015 | CCND3 | LOC107984079 | P2RY12 | SYNGR1 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | BORCS7-ASMT | POSTN | MYL2 | FGB | NOS2 | Prostanoid TP receptor (nonspecified subtype) | JAZF1 | COL4A2 | G7124 | WFS1 | GSTP1 | LOC105369709 | ACAT1 | LRP1 | NFKBIE | PIK3C2G | ACVRL1 | LIPC | MMAA | TCN2 | LOC101928272 | DHX38 | RBMS1 | FASLG | NF-kappaB (NFkB) | LEPR | CBS | ROCK2 | HMGCS2 | Caspase (nonspecified subtype) | EPHB6 | MMP13 | CAPN1 | CPB2 | CARS1 | PRKDC | ADRB2 | MBOAT7 | ANKRD55 | ADIPOR1 | TGFB2 | USF2 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | NEDD9 | VHL | SLC4A8 | G9734 | HNRNPUL1 | SLC23A1 | SQOR | ABCG8 | SYT6 | L-Type calcium channel (nonspecified subtype) | ACKR3 | BCAT1 | MTTP | FGD5 | G672 | HNF1A | NOX3 | RGS5 | GUCY1A1 | SHOC1 | FOLR3 | XPO5 | RXRA | CXCR2 | ADAMTS9-AS2 | PRKCB | GSTM1 | Complement Complex | B4GALT2 | CD80 | LOC285626 | Proteasome Complex | SOAT1 | ATP1B3 | GAA | HCAR1 | CCR5 | KCNQ1 | Histone deacetylase (nonspecified subtype) | TXNRD1 | FPR2 | CYP2J2 | ACOXL | MAP2K2 | KCNQ5 | APEX1 | NLRP3 Inflammasome | WTAPP1 | PON1 | PKM | TEX41 | LOXL2 | G472 | ANKS1B | Poly [ADP-ribose] polymerase (nonspecified subtype) | TNS1 | WDR12 | LOC107984264 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | G114548 | Carboxypeptidase A (nonspecified subtype) | APOE | PDX1 | CEP89 | PRC1-AS1 | HTR3B | Vacuolar H+ ATPase | CCL17 | Glycine receptor | MIR146A | GGCX | BDKRB1 | CTH | DGKD | INHBC | ABCC6 | Integrin alphavbeta6 receptor | SLC22A4 | MIF | G7157 | TYRO3 | Tryptase (nonspecified subtype) | IL12A | CTNNB1 | LOC392232 | BBOX1 | HTR2C | PTPRB | IL4 | SLC5A1 | BTG4 | G3576 | Integrin alpha2beta3 Receptor | KCNK9 | TBC1D10A | PPP3CB | PROKR1 | THBS4 | NAMPT | ITGB3 | NAA25 | SERPINH1 | LINC00709 | HLA-DQB1 | COG6 | APOA1 | AGER | Adenosine receptor (nonspecified subtype) | CYP19A1 | SMAD3 | ZNF217 | OLR1 | AMT | APOC1 | Cannabinoid receptor (nonspecified subtype) | PPP3R1 | NADPH Oxidase Complex | SLC10A2 | SLC34A1 | AGTR2 | ABCA6 | PLAU | LOC102725159 | Nitric oxide synthase (NOS) (nonspecified subtype) | DAB2IP | C3 | NOTCH2 | ALOX5 | GUCY2C | CD47 | ARHGAP26 | MLYCD | LOC107984737 | FTO | LOC100288637 | GATA3 | IGF2BP1 | TMEM170A | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | ABCC1 | FUT1 | DYRK1B | ADAMTS4 | Solute carrier family 29 member (nonspecified subtype) | IL6R | IL13 | CCL19 | P2RX2 | DENND2D | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | CPNE4 | CCL2 | TFDP2 | NPR1 | PLA2G2D | KCNK5 | HSP90B3P | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | G7099 | GLP1R | GOSR2 | Potassium Channels (nonspecified subtype) | ALB | P2RX7 | KL | AS3MT | G596 | CYP4F2 | APOL1 | EGLN1 | LOC101929710 | APOB | CD300LG | PARP12 | FURIN | OASL | LOC100505498 | TP53INP1 | HNF4A | TRPS1 | F2R | GP6 | TARID | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | TGFB1 | LOC105378654 | XRCC1 | BLTP3A | BCAP29 | ENTPD1 | ACYP2 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | SPRED2 | ZC3HC1 | PIK3CG | TTLL5 | FUT2 | Arginase (nonspecified subtype) | CYP11B2 | PLA2G7 | NAT8 | LIPE | VAMP8 | SH2B3 | BCAS3 | CD19 | Endothelin receptor (nonspecified subtype) | SRSF2 | KCNMB1 | Cyclin-dependent kinase inhibitor (nonspecified subtype) | LMOD1 | SLC22A5 | F7 | MTR | KIF6 | TLR6 | TRIB3 | NADPH Oxidase (nonspecified subtype) | CCL21 | LOC101929761 | HMOX1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | MIR196A2 | ABCC4 | STAG1 | Soluble guanylyl cyclase | SCN5A | CRP | Rho kinase (ROCK) (nonspecified subtype) | S1PR1 | MMP1 | ABO | COG5 | LTC4S | CDK1 | TCF7L2 | UMPS | ATF6 | APLN | PHB2 | RAB5B | Glutathione S-Transferase (GST) (nonspecified subtype) | ALPK2 | IL18 | TBXA2R | SOAT2 | PARK7 | FBXW7 | RAET1E | LTA4H | SERPING1 | ITPKC | PROX1 | alpha-Amylase (nonspecified subtype) | VTN | IGF2BP2 | REN | SLC2A2 | LPA | MIR652 | STK39 | CHRM2 | FGFR2 | FMO3 | TSBP1 | AMP-activated protein kinase (AMPK) | SLC29A1 | DDAH2 | CX3CR1 | CYP4A11 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | MICA | C5orf67 | SLC30A8 | MSRA | FABP4 | NEXN | MRAS | ABCC3 | PRKCE | CCL24 | LOC374443 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | MPO | YTHDF3 | RCAN1 | AHSG | LINC01412 | HIF1A | PPARGC1A | ACE | ALDH1B1 | LRP8 | PEX6 | LOC105374925 | PTAFR | NFKB1 | DOCK7 | CMA1 | CRHR2 | Collagen (nonspecified subtype) | RHOA | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | G6714 | EDNRA | GTPBP10 | CDK7 | LOC102723340 | Integrin alpha2beta1 (VLA-2) receptor | MYRF | PROX1-AS1 | MCHR1 | H19 | TLE1-DT | HLA-DRB1 | CXCL16 | G1029 | RASSF9 | ATXN2 | MIR499A | G595 | SIK3 | PON2 | LIPG | CYP3A4 | MIA3 | SLC8A1 | ALOX15 | RAD51B | BDNF | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CUX2 | GPER1 | CNR2 | THBD | CNNM2 | LINC01497 | THADA | TRDMT1 | SELE | CYBA | LTF | GCGR | ZMIZ1 | Glutathione peroxidase (nonspecified subtype) | IL1RN | ERCC5 | COL14A1 | G4780 | SVEP1 | Protein Phosphatase 2B | PML | Na+/Ca2+ Exchanger (NCX) (nonspecified subtype) | LDLR | ADAM33 | CAT | LARP6 | mu-Calpain (calpain 1) | CASC15 | TXNDC11 | SLC5A2 | FADS1 | TRPC3 | CHGA | Monoamine oxidase (MAO) (nonspecified subtype) | THSD7A | PLPP3 | LOC105370176 | PDGFRB | MAGI2 | ADH1C | GPBAR1 | C2 | MS4A2 | BRAP | SPP1 | PLA2G2A | CDH13 | CDK2 | LIG4 | CARD8 | SWAP70 | LINC02863 | CXCL5 | KCNJ11 | CYP2C19 | SIRT6 | HECTD4 | FMN2 | Epoxide Hydrolase (nonspecified subtype) | NR3C2 | G2475 | LINC01312 | WDR25 | NOA1 | CETP | Na+/H+ Exchanger (NHE) (nonspecified subtype) | BDKRB2 | LCAT | LGALS2 | UGT2A1 | HRAS | KCNH2 | DPY19L3-DT | GPR35 | CDK6 | G5562 | TNFRSF11B | CARF | CUBN | GIGYF2 | PPARA | IRF1-AS1 | PCSK1 | LRP6 | KCNAB1 | FAM107A | CCR3 | SREBF1 | ASGR1 | IL33 | G5599 | FFAR4 | TNKS | HFE | Integrin alphavbeta3 (vitronectin) receptor | Calcium channel (nonspecified subtype) | CACNA1B | LOC100506023 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | CAPZA1 | CASZ1 | CDK4 | TAF1A | MACIR | SLC39A8 | ART3 | NPR3 | PDZD2 | PPARG | CSK | TRPM8 | STN1 | GHSR | MYLIP | L-type voltage-dependent calcium channel complex | Protein kinase C (nonspecified subtype) | MYD88 | Integrin alpha4beta1 (VLA-4) receptor | RNF13 | NBEAL1 | MGP | PHACTR1 | KSR2 | DNASE1 | VWF | G2335 | ADK | LPL | Protein Kinase B (PKB/Akt) (nonspecified subtype) | TEC | CYSLTR1 | MIR486-1

Note: If you'd like to get a target analysis report for Coronary Artery Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Coronary Artery Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

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