Polymicrogyria
Polymicrogyria
About the Disease
Polymicrogyria, also known as pmg, is related to megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 and megalencephaly-capillary malformation-polymicrogyria syndrome. An important gene associated with Polymicrogyria is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Development Endothelin-1/EDNRA transactivation of EGFR. Affiliated tissues include brain, cortex and fetal brain, and related phenotypes are nervous system and growth/size/body region
Common Targets
TUBB2B | CCND2 | ADGRG1 | GRIN1 | OCLN | MECP2 | EIF4EBP2 | PIK3R2 | RTTN | CEP135 | AKT3 | HKDC1

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Sialoadenitis | Myelitis, Transverse | Chondrosarcoma | Graft-versus-host Disease | Alveolar Capillary Dysplasia | Anencephaly | Congenital Generalized Lipodystrophy | Epidermolysis Bullosa Dystrophica | Lipid Storage Diseases | Charcot-Marie-Tooth Disease Type 2E | Stiff-man Syndrome | Endometritis | Ligneous Conjunctivitis | Polymicrogyria | Anxiety Disorders | Progressive Encephalopathy-optic Atrophy Syndrome | Hypersomnia | Tricho-hepato-enteric Syndrome | Stomatitis | Nestor-Guillermo Progeria Syndrome | Pituitary Dwarfism | Retinal Telangiectasia | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Rhizomelic Chondrodysplasia Punctata | Oligoastrocytoma | Multiple Myeloma | Guillain-Barre Syndrome | Liver Failure | Histiocytic Sarcoma | Kaposiform Hemangioendothelioma | Alpha-thalassemia Myelodysplasia Syndrome | REM Sleep Behavior Disorder | Epidermal Nevus Syndrome | Myelomeningocele | Urolithiasis | Phosphoglycerate Dehydrogenase Deficiency | Mucormycosis | Spinocerebellar Ataxia Type 28 | Smoldering Myeloma | Neurofibromatosis Type 1 | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Giant Cell Glioblastoma | Japanese Encephalitis | Prostatitis | Hemangioendothelioma | Hypoparathyroidism | Proteus Syndrome | Chorea-acanthocytosis | Rubinstein-Taybi Syndrome | Okihiro Syndrome | Myofibromatosis | Cantu Syndrome | Hepatitis D | T-cell Leukemia | Blau Syndrome | Pituitary Stalk Interruption Syndrome | Posterior Polar Cataract | Oculocutaneous Albinism | Fatty Aldehyde Dehydrogenase Deficiency | Oculocutaneous Albinism Type 4 | Osteosarcoma | Axenfeld-Rieger Syndrome | Nasodigitoacoustic Syndrome | Sialidosis Type I | Pontocerebellar Hypoplasia Type 2 | Epidermolysis Bullosa Simplex | Generalized Epilepsy With Febrile Seizures Plus | Primary Erythromelalgia | Schwannoma | NDH Syndrome | Arthropathy | Acne | Nutrition Disorders | Leukocyte Adhesion Deficiency | Spastic Paraplegia Type 7 | Meningococcal Meningitis | Schizencephaly | Persistent Mullerian Duct Syndrome | Skin Fragility-woolly Hair Syndrome | Autosomal Recessive Spastic Paraplegia Type 75 | Basal Ganglia Disease, Biotin-responsive | Shock, Cardiogenic | Nemaline Myopathy 8 | Acrodermatitis Enteropathica | Paget's Disease Of The Breast | Hypothalamic Obesity | Alpha-1 Antitrypsin Deficiency | Hemolytic Anemia | Neuropathy | Pyruvate Carboxylase Deficiency Disease | Diabetic Encephalopathy | Fontaine Progeroid Syndrome | Neurofibromatosis | Osteogenesis Imperfecta Type V | Thymoma, Malignant | Triple A Syndrome | FG Syndrome | Ornithine Transcarbamylase Deficiency | Becker Muscular Dystrophy | Fahr Disease | Metabolic Diseases | Glycogen Storage Disease Type 6 | Superficial Spreading Melanoma | CDKL5 Deficiency Disorder | Maple Syrup Urine Disease | Idiopathic Pulmonary Fibrosis | Hyperbilirubinemia | Xeroderma Pigmentosum | Mohr-Tranebjaerg Syndrome | Chudley-McCullough Syndrome | Trismus-pseudocamptodactyly Syndrome | PASLI Disease | Scabies | 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Mast Cell Leukemia | Wolfram Syndrome | Down Syndrome | Hemolytic Uremic Syndrome, Atypical | Chronic Kidney Disease | Cancer, Bladder | Conduct Disorder | Cataplexy | Polydactyly | Multiple Hamartoma Syndrome | Achondrogenesis | Takayasu's Arteritis | Riboflavin Transporter Deficiency Neuronopathy | Dyskeratosis Congenita | Epidermolysis Bullosa Simplex, Localized | Burn-McKeown Syndrome | Progressive Familial Intrahepatic Cholestasis Type 3 | Micro Syndrome | IgA Deficiency | Globozoospermia | Glycogen Storage Disease Type 0, Muscle | 3-methylglutaconic Aciduria Type I | Lymphoma, B-cell | Choroideremia | Alpers Syndrome | Hereditary Spherocytosis | Sertoli Cell-only Syndrome | Neurofibromatosis-Noonan Syndrome | Pernicious Anemia | Cardiomyopathy, Hypertrophic | Hemoglobinopathies | Chronic Leukemia | Adrenomyeloneuropathy | Smith-Kingsmore Syndrome | Hepatitis, Autoimmune | Epiphyseal Chondrodysplasia, Miura Type | Kashin-Beck Disease | Dysferlinopathy | Tendinopathy | 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