Pouchitis

About the Disease
Pouchitis is related to inflammatory bowel disease 1 and ulcerative colitis. An important gene associated with Pouchitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Toll-Like receptor Signaling Pathways. The drugs Ciprofloxacin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and bone marrow, and related phenotypes are cellular and immune system

Common Targets
ICAM1 | NOD2 | Integrin alpha4beta7 (LPAM-1) receptor | KCNN4 | IL10 | Interleukin-12 (IL-12) | NF-kappaB (NFkB) | NOX3 | G7124 | IL12A | GLP2R | GLP1R | Intrinsic Tenase Complex | Interleukin 23 complex (IL-23) | DAGLB | IL12B | G4780

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