Pouchitis

About the Disease
Pouchitis is related to inflammatory bowel disease 1 and ulcerative colitis. An important gene associated with Pouchitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Toll-Like receptor Signaling Pathways. The drugs Ciprofloxacin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and bone marrow, and related phenotypes are cellular and immune system

Common Targets
ICAM1 | NOD2 | Integrin alpha4beta7 (LPAM-1) receptor | KCNN4 | IL10 | Interleukin-12 (IL-12) | NF-kappaB (NFkB) | NOX3 | G7124 | IL12A | GLP2R | GLP1R | Intrinsic Tenase Complex | Interleukin 23 complex (IL-23) | DAGLB | IL12B | G4780

Note: If you'd like to get a target analysis report for Pouchitis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Pouchitis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Cancer, Skin | Hypoparathyroidism | Pleural Tuberculosis | Autosomal Recessive Bestrophinopathy | Spinocerebellar Ataxia Type 38 | Spondyloepiphyseal Dysplasia Tarda, X-linked | Primary Carnitine Deficiency | Familial Hypertrophic Cardiomyopathy | Coenzyme Q10 Deficiency | Hereditary Neuropathy With Liability To Pressure Palsies | Focal Cortical Dysplasia Type 2 | Acrocallosal Syndrome | Hypothyroidism | Meningococcal Meningitis | Portal Vein Thrombosis | Pseudohypoparathyroidism Type 2 | Vascular Cognitive Impairment | Paroxysmal Kinesigenic Dyskinesia | Bulimia Nervosa | Fontaine Progeroid Syndrome | Acromicric Dysplasia | Combined Pituitary Hormone Deficiency | Cataplexy | Hyperphenylalaninemia | Sickle Cell Anemia | Klippel-Feil Syndrome | Spinocerebellar Ataxia Type 20 | Tracheal Disorders | Hereditary Elliptocytosis | Isovaleric Acidemia | Retinitis Pigmentosa | McKusick Type Metaphyseal Chondrodysplasia | Primary Progressive Nonfluent Aphasia | Spinocerebellar Ataxia Type 16 | Spinocerebellar Ataxia Type 7 | Cat Eye Syndrome | Hepatitis, Alcoholic | X-linked Myotubular Myopathy | Adenoma, Pleomorphic | Nephritis, Interstitial | Autoimmune Polyendocrine Syndrome | Perry Syndrome | Scoliosis | Spondylocostal Dysostosis | Danon Disease | Seizures-scoliosis-macrocephaly Syndrome | Campomelic Dysplasia | Nephrotic Syndrome | Glycogen Storage Disease Type 9 | Keratosis, Actinic | Hypervalinemia | Pneumonia, Viral | Shwachman-Bodian-Diamond Syndrome | Thromboembolism | Cutis Laxa | Reticular Dysgenesis | Ameloblastic Carcinoma | Porokeratosis | Barakat Syndrome | Cryptococcal Meningitis | Palsy, Cerebral | Guttate Psoriasis | Orotic Aciduria | Neurofibromatosis-Noonan Syndrome | X-linked Charcot-Marie-Tooth Disease | Juvenile Hyaline Fibromatosis | Thyroiditis, Autoimmune | Meningitis | Compartment Syndrome | Raine Syndrome | Congenital Dyserythropoietic Anemia Type 4 | Schwannoma | Alzheimer Disease, Late Onset | Sarcoidosis, Pulmonary | Scapuloperoneal Spinal Muscular Atrophy | Cystitis, Interstitial | Optic Neuritis | Progressive Familial Intrahepatic Cholestasis Type 2 | DRESS Syndrome | Arthritis | Basal Cell Nevus Syndrome | Antithrombin III Deficiency | LMNA-related Congenital Muscular Dystrophy | Woodhouse-Sakati Syndrome | Optic Nerve Hypoplasia, Bilateral | Hemolytic Uremic Syndrome, Atypical | Spina Bifida | Demyelinating Diseases | Cysticercosis | D-2-Hydroxyglutaric Aciduria | Chorea | Extramammary Paget's Disease | Epidermolysis Bullosa Simplex | Ganglioglioma | Dental Caries | Cancer, Brain | Holt-Oram Syndrome | Milk Allergy | Meniere's Disease | Charcot-Marie-Tooth Disease, Type 6 | Sleep Apnea | DOCK8 Immunodeficiency Syndrome | Alkaptonuria | Intestinal Hypomagnesemia 1 | Niemann-Pick Disease, Type C | Ileitis | Hyperinsulinemia | Charcot-Marie-Tooth Disease Type 4B1 | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Giant Cell Arteritis | Proopiomelanocortin Deficiency | Jalili Syndrome | Primary Torsion Dystonia | Congenital Primary Aphakia | Chromosome 16p11.2 Deletion Syndrome | Sengers Syndrome | Chronic Kidney Disease | Melanoma | Waardenburg Syndrome Type 4A | SAPHO Syndrome | Peripheral T-cell Lymphoma | Diffuse Palmoplantar Keratoderma | Batten Disease | Donnai-Barrow Syndrome | Sarcoma, Alveolar Soft Part | Adrenoleukodystrophy, X-linked | Follicular Dendritic Cell Sarcoma | Hypertrophy | Cerebellofaciodental Syndrome | AIDS Dementia Complex | Spinocerebellar Ataxia Type 27 | Mohr-Tranebjaerg Syndrome | Lissencephaly 2 | Glycogen Storage Disease Type 0 | Vitamin B12 Deficiency | Stiff-man Syndrome | Congenital Afibrinogenemia | Bruck Syndrome | Osteosarcoma | Endocarditis | Familial Partial Lipodystrophy | Lymphoproliferative Disorders | Kaposiform Hemangioendothelioma | Microcephaly, Seizures, And Developmental Delay | Thalassemia, Beta | Kabuki Syndrome 2 | Endometriosis | GATA2 Deficiency | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Thyrotoxic Periodic Paralysis | Eosinophilia | Diabetes | T-cell Lymphoma, Subcutaneous Panniculitis-like | Carcinoma, Squamous Cell | Optic Nerve Diseases | Amelanotic Melanoma | Congenital Disorders Of Glycosylation Type II | Acquired Partial Lipodystrophy | Learning Disability | Renal Hypomagnesemia 3 | Open-angle Glaucoma | Pituitary Disorders | Thyroiditis | Acute Chest Syndrome | Schnitzler Syndrome | Congenital Aniridia | Chorea-acanthocytosis | Multicystic Renal Dysplasia | Anti-NMDA Receptor Encephalitis | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Cardiomyopathy, Hypertrophic | Vici Syndrome | Porphyria, Acute Intermittent | Centronuclear Myopathy | Macrophagic Myofasciitis | Kaposi Sarcoma | Migraine | Perivascular Epithelioid Cell Tumor | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Sialoadenitis | Primary Hyperoxaluria | Keratoconjunctivitis | Mevalonate Kinase Deficiency | Pulmonary Tuberculosis | Diabetes Mellitus, Transient Neonatal | Skin Fragility-woolly Hair Syndrome | Hepatitis B, Chronic | Dystrophy, Cone-rod | Bartter Syndrome | Eccrine Porocarcinoma | Congenital Bile Acid Synthesis Defect | Encephalopathy | Sialidosis | Sarcosinemia | Borderline Personality Disorder | Rhabdomyosarcoma, Embryonal | Aneurysm, Thoracic Aortic | Spinal Cord Diseases | Ataxia-ocular Apraxia 2 | Rothmund-Thomson Syndrome | Kindler Syndrome | Autosomal Recessive Congenital Ichthyosis | Evans Syndrome | Epidermolysis Bullosa Dystrophica | Neurocutaneous Melanocytosis | Beckwith-Wiedemann Syndrome | Diabetes Type 1 | Galactosemia | Thrombotic Microangiopathy | Pseudohypoparathyroidism Type 1C | Neurofibrosarcoma | Renal Dysplasia | Otitis Media | Carcinoma, Signet Ring Cell | Cocaine-Related Disorders | Essential Fructosuria | Sturge-Weber Syndrome | Aromatic L-amino Acid Decarboxylase Deficiency | Behcet's Disease | Neuropathy | Endophthalmitis | Tendinopathy | Fibrillation, Atrial | Tinea | Pulmonary Alveolar Microlithiasis | Fetal Alcohol Syndrome | Myelodysplasia | Congenital Bilateral Absence Of Vas Deferens | Myoclonic Epilepsy With Ragged Red Fibers | Fibronectin Glomerulopathy | Waardenburg Syndrome Type 2 | Premature Ejaculation | Diabetes Type 2 | Stargardt Disease | Endometritis | LEOPARD Syndrome | Speech Disorders | Adenylosuccinate Lyase Deficiency | Vertigo | Dysferlinopathy | Hyperlipidemia Type V | Osteoporosis | Benign Familial Pemphigus | Wiskott-Aldrich Syndrome | Neurodegeneration With Brain Iron Accumulation | Spinocerebellar Ataxia Type 12 | Interstitial Lung Diseases | Hypermethioninemia | Presbycusis | Familial Dysautonomia | Yellow Fever | Joubert Syndrome 2 | Carcinoid Syndrome | Synpolydactyly | Erythematotelangiectatic Rosacea | Toxic Epidermal Necrolysis | Keratopathy | Nance-Horan Syndrome | Adams-Oliver Syndrome | Haim-Munk Syndrome | Kohlschutter-Tonz Syndrome | Blepharitis | Renal Failure | Facioscapulohumeral Muscular Dystrophy Type 1 | Scapuloperoneal Myopathy, X-linked Dominant | Personality Disorders | Glutaric Aciduria Type 2 | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Split Hand-foot Malformation | Amyotrophic Lateral Sclerosis | Polycystic Liver | Apraxia | C3 Glomerulonephritis | Large Granular Lymphocytic Leukemia | Gallstones | Hereditary Sensory Neuropathy Type 1 | Hyperparathyroidism-jaw Tumor Syndrome | Leukemia | Multiple Sclerosis | Phenylketonuria | Analgesia | Vitelliform Macular Dystrophy | Borjeson-Forssman-Lehmann Syndrome | Carpal Tunnel Syndrome | Allan-Herndon-Dudley Syndrome | Colorectal Adenoma | Postpoliomyelitis Syndrome | Hereditary Coproporphyria | Granular Corneal Dystrophy | Osteogenesis Imperfecta Type VI | Depression | Charcot-Marie-Tooth Disease, Type 1A | Cutaneous Angiosarcoma | B-cell Chronic Lymphocytic Leukemia | Ollier Disease | Progressive Familial Intrahepatic Cholestasis | Aicardi-Goutieres Syndrome | Harlequin Ichthyosis | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Optic Neuropathy, Anterior Ischemic | Astrocytoma, Anaplastic | Cholelithiasis | Pemphigus Vulgaris | Fascioliasis | Temtamy Preaxial Brachydactyly Syndrome | Hyperlipidemia, Familial Combined | Encephalitis, Tick-borne | 3-methylcrotonyl-CoA Carboxylase Deficiency | Blau Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Fetal Akinesia Deformation Sequence | Corneal Neovascularization | Inflammatory Myopathy | Whipple's Disease | Hypersensitivity Pneumonitis | Cockayne Syndrome | Coffin-Lowry Syndrome | Shprintzen-Goldberg Syndrome | Prurigo Nodularis | Non-Langerhans Cell Histiocytosis | Tumoral Calcinosis | Porencephaly | Cystitis | Hereditary Hemorrhagic Telangiectasia Type 2 | Crigler-Najjar Syndrome | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Acute Lung Injury | Chronic Inflammatory Demyelinating Polyneuropathy | Lymphangioma | McLeod Syndrome | Combined Malonic And Methylmalonic Acidemia | Polycythemia Vera | Paraganglioma, Carotid Body | Silver-Russell Syndrome | Lichen Planus | Gastroschisis | Dementia | Acrodysostosis | Leiomyosarcoma | Bethlem Myopathy | Osteogenesis Imperfecta Type III | Jaundice, Obstructive | Hyperbilirubinemia | Dysplastic Nevus | Rheumatic Heart Disease | Myotonia | Methemoglobinemia | Posterior Polar Cataract | Fabry's Disease | Pseudohypoparathyroidism Type 1A | Cannabis Abuse | Parkinsonism | Tibial Muscular Dystrophy | Stevens-Johnson Syndrome | Becker Muscular Dystrophy | Mannosidase Deficiency Diseases | Heterotaxy | VACTERL/VATER Association | Mitochondrial Disease | Patent Foramen Ovale | Central Core Disease | Pulmonary Stenosis | Congenital Diaphragmatic Hernia | Avellino Corneal Dystrophy | Congenital Myopathy | Citrullinemia | Histiocytosis | Arthropathy | Keloid | Osteogenesis Imperfecta Type I | Coronary Heart Disease | Lymphoproliferative Disease, X-linked | Schizophrenia, Paranoid | Dengue Hemorrhagic Fever | Hypertension, Pulmonary | Glaucomatocyclitic Crisis | Wolfram Syndrome 2 | Chronic Enteropathy Associated With SLCO2A1 Gene | Congenital Heart Block | Metachromatic Leukodystrophy | Hypereosinophilic Syndrome | Craniometaphyseal Dysplasia | Absence Epilepsy | Heterotopic Ossification | Sotos Syndrome | Nutrition Disorders | Non-epidermolytic Palmoplantar Keratoderma | Bicuspid Aortic Valve | Incontinentia Pigmenti | Hoyeraal-Hreidarsson Syndrome | Myocarditis | Anterior Segment Dysgenesis | Craniofrontonasal Syndrome | Polycythemia | Pyruvate Kinase Deficiency | Aspergillosis | Tenosynovial Giant Cell Tumor | Xeroderma Pigmentosum Variant Type | Asplenia | Neuromuscular Disorders