Uveitis

About the Disease
Uveitis is related to anterior uveitis and pars planitis. An important gene associated with Uveitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Lidocaine and Certolizumab pegol have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
IL10 | C2 | ERC2 | Proteasome Complex | HMOX1 | IL23R | MRGPRX1 | GPR137 | HLA-C | CD19 | G7124 | OS9 | HCK | PPIA | Protein Phosphatase 2B | JAK3 | G114548 | JAK1 | HLA-DQB1 | RORC | CFB | Interleukin 17 (nonspecified subtype) | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | CD6 | IL12B | ABCA7 | KCNA3 | MC1R | ANO6 | Serine/Threonine Kinase (nonspecified subtype) | JAK2 | CYSLTR1 | IL1B | Tyrosine-Protein Kinases Src (nonspecified subtype) | CSK | G6774 | ANXA11 | TRAF5 | PDE4B | ITGB1 | CFD | Phosphodiesterase IV (PDE4) (nonspecified subtype) | C5 | CASP10 | IL17RA | PRKCA | G3569 | IL2RA | CCDC88B | FKBP1A | CNR2 | LTA | LCK | HLA-DQA1 | MAPK12 | PPP3R2 | G1432 | MAOA | IL7R | TYK2 | G5133 | PPID | G4851 | PPP3CC | G7099 | BTNL2 | NF-kappaB (NFkB) | BAD | NOD2 | CD86 | NOTCH4 | DHODH | IL-2 receptor | HLA-B | PECAM1 | G7852 | Uncharacterized LOC102724748 | NCOA5 | CNR1 | G673 | HLA-DRB1 | ITK | Interleukin-12 (IL-12) | HLA-DRA | G142 | HERC2 | PRKCD | BLTP1 | TRPV1 | SYK | G3605 | Voltage-Gated Sodium Channel Complex | PTGDR | G920 | ADORA3 | Heme Oxygenase (HO) (nonspecified subtype) | NADSYN1 | PTGS1 | Prostanoid TP receptor (nonspecified subtype) | HLA-A | IRF5 | NUAK1 | PTGER4 | TLR2 | G2475 | Integrin alphaLbeta2 (LFA-1) receptor | RAB23 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | FAAH | HSPA1A | G3630 | STAT4 | CD80 | Sodium channel (nonspecified subtype) | TGFB2 | PDCD1LG2 | ERAP1 | CAPN5 | FPR2 | PRKCB | PTGER1 | IL12A | Janus Kinase (nonspecified subtype) | PTPN22 | ASIC1 | F11 | Complement Complex | FASLG | PPP3CB | PRKCQ | CMKLR1 | NR3C1 | ARHGEF2 | HLA-DPB1 | PPP3R1 | FGG | KLKB1 | MAPK13 | CFH | HSPA1L | MIR146A | NPC1 | TLR9 | FAS | Tubulin | P2RX7 | CD28 | NOS2 | TRPA1 | STING1 | CYP27B1 | TGFB3 | IFNG | PRKCE | CCR5 | G5743 | PTGFR | TXK | SIK3 | MAOB | Interleukin 23 complex (IL-23) | DHFR | IFNAR2 | IL6R | AOC3 | METTL1 | RIPK2 | ETS1

Note: If you'd like to get a target analysis report for Uveitis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Uveitis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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