Autosomal Recessive Spastic Paraplegia Type 35

About the Disease
Hereditary Spastic Paraplegia 35, also known as autosomal recessive spastic paraplegia type 35, is related to spastic paraplegia 7, autosomal recessive and mast syndrome, and has symptoms including ataxia, seizures and urgency of micturition. An important gene associated with Hereditary Spastic Paraplegia 35 is FA2H (Fatty Acid 2-Hydroxylase), and among its related pathways/superpathways are Autophagy and superpathway of coenzyme A biosynthesis III (mammals). The drug Iron has been mentioned in the context of this disorder. Affiliated tissues include globus pallidus, brain and subthalamic nucleus, and related phenotypes are spastic paraplegia and babinski sign

Common Targets
FA2H

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