Nicotine Dependence

About the Disease
Smoking As a Quantitative Trait Locus 3, also known as lung cancer susceptibility 2, is related to tobacco addiction and substance dependence. An important gene associated with Smoking As a Quantitative Trait Locus 3 is CHRNA3 (Cholinergic Receptor Nicotinic Alpha 3 Subunit), and among its related pathways/superpathways are Transmission across Chemical Synapses and Postsynaptic nicotinic acetylcholine receptors. The drugs Naltrexone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prefrontal cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
GABBR1 | CHRNB3 | Nicotinic alpha4beta2alpha5 Receptor | PPARG | Nicotinic alpha6beta2alpha4beta2beta3 receptor | COMT | CYP2A6 | HTR1A | CNR1 | TTC12 | CHRNB4 | Nicotinic (alpha4beta2)2alpha4 receptor | ADRA2B | COMMD7 | GLIS3 | Nicotinic (alpha4beta2)2beta2 receptor | NCAM1 | NRG1 | ANKK1 | HCRTR1 | PSMA4 | G3630 | PRICKLE2 | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | DBH | GRM2 | CHRNA7 | TTC28 | DRD5 | Nicotinic alpha3beta4 Receptor | Nicotinic alpha4beta2 receptor | DNMT3B | CHRNA2 | OPRD1 | HYKK | ADAMTSL1 | KANK1 | SLC6A4 | TEK | HTR2A | HCRTR2 | TRPA1 | NRXN1 | CHRNA3 | HTR1B | HTR3B | NF-kappaB (NFkB) | EFCAB8 | ANAPC1 | MAPRE1 | HTR2C | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | NPFFR1 | CNTN4 | Nicotinic alpha4beta4 receptor | NOL4L | SLCO3A1 | GPR55 | NAAA | CHRNA4 | alpha-6 beta-2 Nicotinic receptor | Nicotinic alpha6beta2beta3 receptor | CHRNA6 | GRIN2B | CHRNB2 | Neuronal acetylcholine receptor alpha2beta2 receptor | Nicotinic alpha3beta2 receptor | Neuronal acetylcholine receptor alpha2beta2 receptor | GRIN3A | SLC1A2 | GALR1 | ZCCHC14 | OPRM1 | BDNF | CHRNA5 | CHRNA1 | GPR143 | OPRK1 | CNR2 | DRD2 | HTR3A | Nicotinic alpha1beta1deltagamma Receptor

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