Thrombocytopenia

About the Disease
Thrombocytopenia, also known as platelet dysfunction nos, is related to thrombocytopenia due to platelet alloimmunization and amegakaryocytic thrombocytopenia, congenital. An important gene associated with Thrombocytopenia is WAS (WASP Actin Nucleation Promoting Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and NF-kappaB Signaling. The drugs Certoparin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and liver, and related phenotypes are homeostasis/metabolism and cellular

Common Targets
GPR25 | ETS2 | FCGR1A | TRAPPC8 | NAT2 | CYP1A1 | F13A1 | DPP4 | SYK | MAP2K7 | FXYD1 | SCEL | TBX1 | MCC | TLR2 | G7015 | G836 | LATS1 | DDRGK1 | SPACA9 | G3605 | TPM4 | IFNL3 | RRM1 | PMS2 | GSTT1 | FCGRT | ITGA2 | NOC3L | MANEA | RAD52 | ABCC5 | CDA | IKZF5 | MUTYH | ZSCAN26 | PRKACG | CHM | HCP5 | ABCC2 | CSF3R | WAS | DOC2B | GP1BA | GLYATL3 | TSPOAP1 | RAC2 | ZNF84 | OR12D3 | GATA1 | TNFSF13B | CYTOR | SLFN14 | JAK2 | ITGB1 | PPP1R32 | PDGFRA | ITGA8 | RGS17 | GALE | ERCC2 | TLR9 | ETV6 | ZSCAN12 | SLC17A3 | TGM2 | FCGR3A | GSTP1 | MIR492 | DCK | MSH5 | MS4A1 | GADD45B | CLTCL1 | CASP10 | JMJD1C | ATP7A | FLNA | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | FUT8 | TIRAP | LOC344967 | G7099 | SLC19A1 | CYP2C8 | GP1BB | JAK3 | JAK1 | MT1B | XRCC3 | TSBP1-AS1 | CYP3A5 | Proteasome Complex | ADH1B | EIF3A | ACVR2A | KIF15 | SERPINC1 | G581 | SBF2 | VIPR1 | CYCS | MCTP2 | FASLG | UGT1A6 | CXCL12 | MAPK9 | STAT4 | MECOM | RICTOR | GAA | TMEM45B | GSTM1 | MGMT | GP9 | GADD45A | ACTN1 | AQP8 | G196 | FLI1 | CBR1 | ZNF311 | UROS | TUBB1 | DYRK3 | SLC29A3 | ZBTB5 | UTS2 | ACP5 | STIM1 | RAD51 | DDX53 | IL-3 receptor | GADD45G | MPIG6B | SLC22A16 | YLPM1 | PSMB1 | RXRA | TYMS | UGT1A1 | AHSA1 | DNHD1 | ZNF204P | GFI1B | BLTP1 | IL11RA | MMS19 | SLCO1B1 | IL6R | DCTD | SPTBN5 | FCGR2A | ANKRD26 | IL15RA | TLE1 | FYB1 | IL13 | XYLT2 | KIAA1328 | MPL | HLA-C | TRIM27 | FOLR3 | SFTPD | XRCC1 | G5243 | LOC105378314 | HLA-DRB1 | TRIM31 | MIR193BHG | ITPA | DHFR | OR2B2 | ABCC1 | RUNX1 | GRK5 | ITGB3 | PTH1R | HPS1 | NQO1 | DGKD | HIF1A | SERPINA1 | CYP2B6 | OR14A2 | BTK | HK2 | FNDC1 | G7124 | LOC105378508 | MTHFR | PDCD2 | ANKH | GNA14 | MAML1 | TNXB | F2R | IFNL4 | PDE4A | LRP2 | POLR2A | FPGS | SLC25A1 | SERPINA5 | CLEC4M | Angiotensin receptor (AT) (nonspecified subtype) | H3C11 | EPHX1 | GPRC6A | SIX5 | NR3C1 | CDSN | NAPRT | DOCK8 | MAS1 | GASK1A | G6714 | GSDMD | G5743 | PRKCE | H1-5 | DPYD | MEIS1 | ATAT1 | THPO | UBD | TBXA2R | SLC29A1 | PGBD1 | ABCC3 | NECTIN2 | CYP3A4 | SFXN4 | TSBP1 | PPP1R18 | FBXL18 | SLCO1B3 | IL12B | MIR4649 | GGH | CDC42 | ALDOB | MYL7 | ERCC5 | MYO5A | LIG3 | TLR1 | RAP1B | KDR | DNA Methyltransferase (DNMT) (nonspecified subtype) | LOC105376740 | SLC31A1 | ANKRD24 | CTDP1 | IL1B | ERCC1 | PPT1 | FANCC | HCG20 | PRRC2A | NDUFAF7 | G9429 | MAGI2 | NOTCH3 | ZNF132 | INPP5D | XPC | CD40LG | G7852 | LUZP4 | GIMAP5 | G5599 | H2BC13 | VWF | CSF3 | NKAPL | MAP2K4 | ZKSCAN2 | MYH9 | MUCL3 | SSPOP | HELB | ALDH2 | NT5C2 | GYPA | G1432 | C6orf15 | IL10 | CD209 | SLC22A1 | TUBB | G1026 | ROCK1 | NEURL4 | DST | MASTL | GNE | MAP3K4 | LINC00243 | SULT1A1 | VAMP2 | NF-kappaB (NFkB) | PDGFB | BIVM-ERCC5 | H4C16 | FLT3 | LINC00312 | SLC28A3 | GABRG2

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