Astrocytoma

About the Disease
Glioma Susceptibility 1, also known as astrocytoma, is related to childhood brain stem glioma and chordoid glioma, and has symptoms including headache and seizures. An important gene associated with Glioma Susceptibility 1 is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Transcription_Transcription factor Tubby signaling pathways and Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome. The drugs Dabrafenib and Trametinib have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related phenotypes are astrocytoma and ependymoma

Common Targets
TH2LCRR | HEATR3 | STN1 | BICRA | ZBTB16 | GSR | ERCC1 | TSC1 | THBS1 | KIT | G595 | AKAP12 | TFRC | Heat shock protein 90 (nonspecified subtype) | G29126 | CDK6 | CTAG1A | CSF1R | CD3 Complex (T Cell Receptor Complex) | G5728 | NOS1 | PRDM16 | BMI1 | Cyclin-dependent kinase (nonspecified subtype) | G673 | FKBP1A | CDK4 | SLC16A8 | GPNMB | AKAP6 | CDKN2B | IDH1 | AGT | G1029 | IL4R | ST6GAL1 | PDGFRB | CDK9/Cyclin T1 | LPP | G4851 | C11orf65 | BCR | CYP1A1 | EXO1 | XRCC6 | F3 | G142 | BRD4 | TMPRSS6 | ANXA5 | CDK9 | CDKN2B-AS1 | MTRR | WIF1 | PHLDB1 | G2475 | CYP2E1 | G7157 | TSC2 | Integrin alpha5beta1 (VLA-5) receptor | CHAF1A | CASP8 | CCNT1 | SELP | EPO | LRRC31 | XRCC3 | KLC3 | ZGPAT | G3480 | PCSK7 | MLH3 | ERCC2 | Tubulin | SPTB | RYR2 | GSDMB | G836 | RTEL1 | PRKDC | MAML2 | IDH2 | WRAP53 | POLR3B | RB1 | G4233 | IKZF3 | CLCN3 | FASN | ZBTB46 | FLT3 | XRCC4 | POLR2A | CTAG1B | G5243 | PDGFRA | RET | EME1 | EPB41L3 | MGMT | TOP2A | LIG1 | IL10 | KDR | Cyclin-dependent kinase inhibitor (nonspecified subtype) | MTHFR | SFRP1 | XRCC5 | G1956 | AKT3 | MYCN | Histone deacetylase (nonspecified subtype) | HPSE2 | RRAS | GSTP1 | ETFA | G7422 | MAPK7 | SOX11 | MIR196A2 | CDC6 | SLC2A4RG | MTR | ALOX5 | C2orf80 | XRCC1 | VTI1A | CYP19A1 | ZPBP2 | G472 | RASSF2 | RHBDF1 | TNFRSF9 | RTEL1-TNFRSF6B | ABL1 | IL13 | G7015 | LRIG1 | ZMIZ1 | JAK2 | LIG4 | IDO2 | SMARCAL1 | MDM4 | FASTKD3

Note: If you'd like to get a target analysis report for Astrocytoma, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Astrocytoma at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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