Sclerosteosis

About the Disease
Sclerosteosis 1, also known as sost1, is related to van buchem disease and craniodiaphyseal dysplasia, and has symptoms including unspecified visual loss An important gene associated with Sclerosteosis 1 is SOST (Sclerostin), and among its related pathways/superpathways are Vitamin D receptor pathway and RUNX2 regulates bone development. The drug Diphosphonates has been mentioned in the context of this disorder. Affiliated tissues include bone, medulla oblongata and bone marrow, and related phenotypes are frontal bossing and large face

Common Targets
SOST | LRP4

Note: If you'd like to get a target analysis report for Sclerosteosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Sclerosteosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Porencephaly | McLeod Syndrome | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Retinoschisis | Corneal Dystrophies, Hereditary | D-2-Hydroxyglutaric Aciduria | Coronary Restenosis | Autoimmune Autonomic Ganglionopathy | Arthrogryposis | Myopia | Neuromyotonia | Neuroma | Angiosarcoma Of The Breast | Neurofibromatosis Type 2 | Glaucomatocyclitic Crisis | Triphalangeal Thumb-polysyndactyly Syndrome | Cutaneous Lupus Erythematosus | Pyelonephritis | Anxiety Disorders | Autosomal Recessive Congenital Ichthyosis | Central Core Disease | Lymphoma | Polyarteritis Nodosa | Basan Syndrome | Lupus Erythematosus | Spinal Muscular Atrophy Type 3 | Cardiospondylocarpofacial Syndrome | Cold-induced Sweating Syndrome | Glycogen Storage Disease Type 3 | Hemorrhage | Tyrosinemia Type 1 | Meniere's Disease | Nanophthalmos | Tatton-Brown-Rahman Syndrome | Corneal Ulcer | Trimethylaminuria | Corneal Edema | Niemann-Pick Disease | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Melanocytic Nevus | Hypereosinophilic Syndrome | Congenital Absence Of Vas Deferens | Glycogen Storage Disease Type 0, Muscle | Desmosterolosis | Delirium | Meningeal Melanocytoma | Hypoproteinemia, Hypercatabolic | Corneal Neovascularization | Vasculitis | Hemangioma | Chordoma | Galloway-Mowat Syndrome | Myosin Storage Myopathy | Combined Malonic And Methylmalonic Acidemia | Carcinoma, Transitional Cell | Farber Disease | Sepiapterin Reductase Deficiency | Glycogen Storage Disease | Urea Cycle Disorder | Pure Red Cell Aplasia | Dominant Optic Atrophy | Central Retinal Artery Occlusion | Guttate Psoriasis | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Keratitis | Gynecomastia | Congenital Afibrinogenemia | Hereditary Folate Malabsorption | Lymphopenia | Sjogren Syndrome | Chronic Granulomatous Disease, X-linked | Dwarfism | Episodic Ataxia Type 1 | Cantu Syndrome | Eosinophilia | Hypogammaglobulinemia | Cervical Dystonia | Evans Syndrome | Sporadic Inclusion Body Myositis | Hyperphosphatasia With Intellectual Disability Syndrome 4 | POEMS Syndrome | Fibromyalgia | Generalized Epilepsy And Paroxysmal Dyskinesia | Usher Syndrome Type II | Gastric Atrophy | Congenital Adrenal Hyperplasia | Sialoadenitis | Vitamin D Deficiency | Malignant Fibrous Histiocytoma | Spinocerebellar Ataxia Type 31 | Diverticulitis | Sarcoidosis | Schamberg Disease | Blood Protein Disorders | Blastoma, Pleuropulmonary | Optic Atrophy 2 | Stickler Syndrome | Neuroblastoma | Skin Carcinoma | Schindler Disease | McKusick Type Metaphyseal Chondrodysplasia | Polycystic Ovary Syndrome | Down Syndrome | Angiosarcoma | Pyoderma Gangrenosum | Reflex Epilepsy | Weill-Marchesani Syndrome | Cocaine-Related Disorders | Muckle-Wells Syndrome | Sandhoff Disease | Sorsby Fundus Dystrophy | Trachoma | Fatty Aldehyde Dehydrogenase Deficiency | Robinow Syndrome | Carcinoid Tumor | Osteogenesis Imperfecta | Rhinitis | Osteoglophonic Dysplasia | Amenorrhea | Saethre-Chotzen Syndrome | Sturge-Weber Syndrome | Polyomavirus Nephropathy | Hepatitis E | Congestive Heart Failure | Bartter Syndrome | Congenital Fiber-type Disproportion Myopathy | Achromatopsia | Infantile Refsum Disease | Asthma, Exercise-induced | Chordoid Glioma | Ocular Hypertension | Dystrophy, Cone-rod | Sialidosis | Congenital Nystagmus | Compartment Syndrome | Waardenburg Syndrome Type 1 | Neuromyelitis Optica | Colon Adenoma | Duodenal Atresia | Ataxia-ocular Apraxia 2 | Alexander Disease | Encephalopathy | Wolcott-Rallison Syndrome | Alpha-1 Antitrypsin Deficiency | Epithelial-myoepithelial Carcinoma | Acrodysostosis | Vitamin A Deficiency | Aplasia Cutis Congenita | Fuchs Heterochromic Iridocyclitis | Lentigo | Pleural Tuberculosis | Jaundice, Obstructive | Neonatal Progeroid Syndrome | Nemaline Myopathy 10 | Giant Axonal Neuropathy | Tyrosinemia Type 2 | Enterocolitis, Necrotizing | Parkinsonism | Jalili Syndrome | Pfeiffer Syndrome | Amebiasis | Adenoid Cystic Carcinoma | Hypolipoproteinemia | Schizophrenia | Spondylolisthesis | Primary Hyperoxaluria Type 3 | Carbamoyl Phosphate Synthetase I Deficiency | Facioscapulohumeral Muscular Dystrophy Type 2 | Cardiac Sarcoidosis | Light Chain Amyloidosis | Cirrhosis | Hyperinsulinism-hyperammonemia Syndrome | Microtia | Cone Dystrophy | Familial Cerebral Amyloid Angiopathy | Blepharospasm | Marfan Syndrome | REM Sleep Behavior Disorder | Hepatitis, Chronic | Scleroderma | Orthostatic Intolerance | Waardenburg Syndrome Type 2A | Lactose Intolerance | Frontometaphyseal Dysplasia | Cardiofaciocutaneous Syndrome | Nestor-Guillermo Progeria Syndrome | Mitochondrial Myopathy | Anterior Segment Dysgenesis | Swine Influenza | Vertebrobasilar Insufficiency | Familial Episodic Pain Syndrome | Autism Spectrum Disorders | Behavioral Variant Of Frontotemporal Dementia | Goldenhar Syndrome | Pneumonia, Mycoplasma | Bronchiolitis | Benign Familial Neonatal Convulsions | Spondylocostal Dysostosis | Gnathodiaphyseal Dysplasia | Neurofibromatosis Type 1 | IMAGe Syndrome | Hyper IgE Syndrome | Kaposi Sarcoma | Sensorineural Hearing Loss | Sporadic Hemiplegic Migraine | Myocardial Infarction | Bare Lymphocyte Syndrome | Mast Cell Leukemia | DOCK8 Immunodeficiency Syndrome | Persistent Mullerian Duct Syndrome | Speech Disorders | Hyperinsulinemia | Idiopathic Multicentric Castleman Disease | Onchocerciasis | Alstrom Syndrome | Iron Metabolism Disorders | Keratitis-ichthyosis-deafness Syndrome | CHARGE Syndrome | Progressive Familial Intrahepatic Cholestasis Type 1 | Hyperlipidemia | Diabetes Insipidus, Neurogenic | Hyperparathyroidism, Primary | CDKL5 Deficiency Disorder | Keratosis | Chronic Thromboembolic Pulmonary Hypertension | Fetal And Neonatal Alloimmune Thrombocytopenia | Hypoparathyroidism | Hermansky-Pudlak Syndrome | Pneumonia, Viral | Early Infantile Epileptic Encephalopathy 13 | Chromosome 5q Deletion Syndrome | Nephropathy | Prurigo Nodularis | Atopic Dermatitis | Pure Autonomic Failure | Pemphigus | Hyperoxaluria | Hypertensive Nephropathy | Tricho-hepato-enteric Syndrome | Tuberculous Meningitis | Hemolytic Anemia | Mumps | Hepatitis, Alcoholic | Neurodermatitis | Osteopathia Striata With Cranial Sclerosis | Microvillus Inclusion Disease | X-linked Creatine Transporter Deficiency | Rheumatoid Arthritis | Pseudoexfoliation Syndrome | Scapuloperoneal Spinal Muscular Atrophy | Stroke, Hemorrhagic | Postpoliomyelitis Syndrome | Spinocerebellar Ataxia Type 16 | Retinal Detachment | Yellow Fever | Bone Giant Cell Tumor | Cri-du-chat Syndrome | Hemolytic Uremic Syndrome | Achondrogenesis | DICER1 Syndrome | Blepharitis | Epidermolysis Bullosa | Autoimmune Polyendocrinopathy Syndrome Type I | Antithrombin III Deficiency | Panniculitis | High Molecular Weight Kininogen Deficiency | Trismus-pseudocamptodactyly Syndrome | Thyroiditis | Stuve-Wiedemann Syndrome | Osteochondroma | Spinal Muscular Atrophy | Fibronectin Glomerulopathy | Patent Foramen Ovale | Myoclonus | Asthma | Carey-Fineman-Ziter Syndrome | Anthrax | Shock, Cardiogenic | Combined Deficiency Of Factor V And Factor VIII | Hypertriglyceridemia | Cenani-Lenz Syndactyly Syndrome | Chromosome 16p11.2 Deletion Syndrome | Hypotrichosis Simplex | Varices | Epidermal Nevus Syndrome | Antisocial Personality Disorder | Schnyder Crystalline Corneal Dystrophy | Communication Disorders | Ileitis | Thalassemia, Beta | Tinea Versicolor | Craniosynostosis | Muir-Torre Syndrome | Myelodysplasia | Sclerosteosis | Aceruloplasminemia | Dentinogenesis Imperfecta | Mucormycosis | Periodic Limb Movement Disorder | Ichthyosis Hystrix, Curth-Macklin Type | Myofibromatosis | Renal Hypouricemia | Autosomal Recessive Spastic Paraplegia Type 35 | Campomelic Dysplasia | Charcot-Marie-Tooth Disease Type 4 | Myofibrillar Myopathy | Familial Hyperaldosteronism | Vici Syndrome | Shprintzen-Goldberg Syndrome | Anemia | Osteonecrosis | Infectious Diarrhea | Infantile Liver Failure Syndrome 1 | Mycosis Fungoides | Hemolytic Uremic Syndrome, Atypical | Nail Disorder, Nonsyndromic Congenital | Usher Syndrome Type I | Prediabetes | Danon Disease | Monilethrix | VEXAS Syndrome | Pompe Disease | Osteitis | Focal Cortical Dysplasia Type 2 | Myoclonus-dystonia Syndrome | Azoospermia | Pyruvate Kinase Deficiency | Gardner Syndrome | Oral Lichen Planus | Gangliosidosis | Cysticercosis | Mevalonate Kinase Deficiency | Bacterial Meningitis | Subacute Sclerosing Panencephalitis | Gigantism | Peroxisomal Disorder | Hyperhomocysteinemia | Microphthalmia, Syndromic 7 | Joubert Syndrome | Cousin Syndrome | Frontotemporal Dementia | Vascular Calcification | Ulcerative Colitis | Olmsted Syndrome | Optic Nerve Hypoplasia, Bilateral | Herpes Genitalis | Metaphyseal Chondrodysplasia, Schmid Type | Ventricular Septal Defect | Creatine Deficiency Syndrome | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Mitochondrial DNA Depletion Syndrome 13 | Hyperkeratosis | Oligodendroglioma | Richter's Syndrome | Low Tension Glaucoma | Gitelman Syndrome | Tardive Dyskinesia | Liver Failure | Carbonic Anhydrase VA Deficiency | Carpenter Syndrome | Ocular Albinism Type 1 | Paracoccidioidomycosis | LRBA Deficiency | Cholangitis | Infantile Nephropathic Cystinosis | Thyroid Hormone Resistance | Spinocerebellar Ataxia Type 40 | Meningococcal Meningitis | Vitiligo | Myhre Syndrome | Cancer, Skin | Autosomal Recessive Spastic Paraplegia Type 54 | Rotor Syndrome | Beare-Stevenson Syndrome | Sotos Syndrome | Myocarditis | Haim-Munk Syndrome | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Tuberculosis | Supravalvular Aortic Stenosis | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Bipolar Disorder | Borjeson-Forssman-Lehmann Syndrome | Focal Dermal Hypoplasia | Pulverulent Zonular Cataract | Spinocerebellar Ataxia Type 27 | Schwartz-Jampel-Aberfeld Syndrome | Guanidinoacetate Methyltransferase Deficiency | Lysosomal Acid Lipase Deficiency | Infantile Neuroaxonal Dystrophy | Spitzoid Melanoma | Argininosuccinic Aciduria | Cushing Syndrome | Trichuriasis | Hypospadias | Distal Myopathy | Gerstmann-Straussler-Scheinker Syndrome | Thrombotic Microangiopathy | Hemorrhagic Disorders | Desbuquois Syndrome