Optic Atrophy 2

About the Disease
Optic Atrophy 2, also known as opa2, is related to 3-methylglutaconic aciduria, type iii and optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy. An important gene associated with Optic Atrophy 2 is OPA2 (Optic Atrophy 2 (Obscure)). Affiliated tissues include eye, and related phenotypes are optic atrophy and progressive visual loss

Common Targets
MTFMT | SLC25A46 | DNM1L | POLG | WFS1 | TMEM126A | OPA1 | MED12 | ND6 | OPA3

Note: If you'd like to get a target analysis report for Optic Atrophy 2, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Optic Atrophy 2 at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Portal Vein Thrombosis | Hypermethioninemia | Retinal Detachment | Fragile X Syndrome | Congenital Nystagmus | Granuloma Annulare | Keloid | Glutaric Aciduria Type 2 | Noonan Syndrome | MELAS Syndrome | Ependymoma | Camptocormia | Bruck Syndrome | Myoclonic Epilepsy With Ragged Red Fibers | Pseudohypoparathyroidism Type 1B | Pneumothorax | Adenocarcinoma | Early Infantile Epileptic Encephalopathy 28 | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Sengers Syndrome | Alopecia | Pseudoachondroplasia | Sandhoff Disease | Nemaline Myopathy 8 | Erysipelas | Diabetes Gestational | Palmoplantar Keratoderma | Hypoglycemia | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Temporal Lobe Epilepsy | Trachoma | Purpura, Thrombotic Thrombocytopenic | FG Syndrome | Mitochondrial Encephalomyopathy | Motor Neuron Diseases | Dermatomyositis | Primary Familial Brain Calcification | Parkinsonism | Nicotine Addiction | Goiter, Nodular | Otosclerosis | Avian Influenza | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Autosomal Recessive Bestrophinopathy | Brachial Plexus Neuropathy | Usher Syndrome Type II | Spondylosis | Spinocerebellar Ataxia Type 38 | H Syndrome | Keratoconus | Endometrial Hyperplasia | Hemangioendothelioma | Infantile Spasm | Colitis, Lymphocytic | Spitzoid Melanoma | Pancreatitis | Ligneous Conjunctivitis | Takotsubo Cardiomyopathy | Lamellar Ichthyosis | Follicular Dendritic Cell Sarcoma | Paroxysmal Nocturnal Hemoglobinuria | Retinopathy Of Prematurity | Pneumonia, Bacterial | Coronary Heart Disease | Cancer, Colon | Pityriasis Rubra Pilaris | Rheumatoid Arthritis | Oculopharyngeal Muscular Dystrophy | Bronchitis, Chronic | Lymphoma, B-cell | Spitz Nevus | Adrenomyeloneuropathy | Anthrax | Arts Syndrome | Kashin-Beck Disease | Distal Myopathy | Hepatic Veno-occlusive Disease | Cirrhosis | Myositis, Focal | Sepiapterin Reductase Deficiency | Christianson Syndrome | Juvenile Polyposis | Epidermolysis Bullosa Simplex, Localized | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Pyelonephritis | Acute Chest Syndrome | Autoimmune Autonomic Ganglionopathy | Facioscapulohumeral Muscular Dystrophy | Ichthyosis, X-linked | Arthritis, Gouty | Moyamoya Disease | Cerebral Cavernous Malformations | Colon Adenoma | Arterial Tortuosity Syndrome | McLeod Syndrome | Fukuyama Congenital Muscular Dystrophy | Language Disorders | Polycystic Kidney, Autosomal Recessive | Alkaptonuria | Triple A Syndrome | Rubinstein-Taybi Syndrome | Primary Hyperoxaluria Type 1 | Alpha-1 Antitrypsin Deficiency | Carney-Stratakis Syndrome | Long QT Syndrome Type 1 | Antisynthetase Syndrome | Paroxysmal Kinesigenic Dyskinesia | Hyperinsulinism-hyperammonemia Syndrome | Craniopharyngioma | Esophageal Motility Disorders | Proteasome-associated Autoinflammatory Syndrome 2 | Retinal Diseases | Fontaine Progeroid Syndrome | CEDNIK Syndrome | Optic Neuropathy | Adrenal Insufficiency | Acral Lentiginous Melanoma | POEMS Syndrome | Pseudo-pseudohypoparathyroidism | Lateral Meningocele Syndrome | Hyperparathyroidism, Secondary | Occipital Neuralgia | Goiter | Dominant Optic Atrophy | Giant Axonal Neuropathy | Isovaleric Acidemia | Osteosclerosis | Williams Syndrome | Hemophilia | NGLY1 Deficiency | Marshall-Smith Syndrome | Ocular Surface Squamous Neoplasia | Seasonal Mood Disorder | Acromicric Dysplasia | AIDS Dementia Complex | Rash | Fowler's Syndrome | Restless Legs Syndrome | Early Infantile Epileptic Encephalopathy 4 | Homocystinuria | Osteoglophonic Dysplasia | Diverticulitis | Werner's Syndrome | Teratozoospermia | Microphthalmia, Syndromic 7 | Hepatitis B, Chronic | Chitayat Syndrome | Panuveitis | Cenani-Lenz Syndactyly Syndrome | GATA2 Deficiency | Histiocytosis | Brugada Syndrome 1 | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Rift Valley Fever | Osmotic Demyelination Syndrome | Spinocerebellar Ataxia Type 17 | Primary Ovarian Insufficiency | Congenital Diaphragmatic Hernia | Smoldering Myeloma | Overactive Bladder | Leber Congenital Amaurosis | Congenital Muscular Dystrophy | TARP Syndrome | Pericarditis | Chorea-acanthocytosis | Pathological Gambling | Pemphigus | Sarcoidosis, Pulmonary | Giant Cell Glioblastoma | Meniere's Disease | Lymphoma, Mantle Cell | Amelanotic Melanoma | Tuberculosis | Sickle Cell Disease | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Benign Familial Neonatal Convulsions | Pituitary Disorders | Citrullinemia | Metachondromatosis | Viral Meningitis | Colorectal Adenoma | ICF Syndrome | Intermittent Explosive Disorder | Epidermolysis Bullosa Acquisita | Geleophysic Dysplasia | Hypertriglyceridemia | Liver Diseases | Mood Disorder | Fascioliasis | Craniolenticulosutural Dysplasia | Heart Septal Defects | Keratoconjunctivitis | Paronychia | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Burn-McKeown Syndrome | Stickler Syndrome | Rickets | Spinocerebellar Ataxia Type 20 | Meningioma, Benign | Hemolytic Uremic Syndrome, Atypical | Delirium | Dubin-Johnson Syndrome | Epidermolysis Bullosa Simplex, Generalized | Oguchi Disease-2 | Aphasia | Craniosynostosis | Trigonocephaly | Borjeson-Forssman-Lehmann Syndrome | Aneurysm, Abdominal Aortic | Genee-Wiedemann Syndrome | Split Hand-foot Malformation | Gingivitis | Pulmonary Vein Stenosis | Congenital Primary Aphakia | Necrobiosis Lipoidica | Long QT Syndrome Type 3 | Hereditary Neuropathy With Liability To Pressure Palsies | Asperger Syndrome | Amyloidosis | Iron Metabolism Disorders | Inflammatory Bowel Disease | Sickle Cell Anemia | Warsaw Breakage Syndrome | Glycogen Storage Disease Type 0 | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Prune Belly Syndrome | Mast Cell Leukemia | Leukemia | Neurogenic Bladder | Meconium Ileus | Farber Disease | Kohlschutter-Tonz Syndrome | Leukoplakia | Mastitis | Hypothyroidism | Oligodendroglioma | Polydactyly | Muscular Dystrophy | Pitt-Hopkins Syndrome | Retinal Coloboma | ACTH-independent Macronodular Adrenal Hyperplasia | Motion Sickness | Low Tension Glaucoma | Patent Foramen Ovale | Diabetic Macular Edema | Epilepsy Of Infancy With Migrating Focal Seizures | Polymyositis | Hemochromatosis Type 2 | Spondylolisthesis | Hidradenitis Suppurativa | Neuronal Ceroid Lipofuscinosis | Von Willebrand Disease | Ornithine Transcarbamylase Deficiency | Cholangiocarcinoma | Thrombasthenia | Prolactinoma | Contact Dermatitis | Familial Hypertrophic Cardiomyopathy | VACTERL/VATER Association | Acute Lung Injury | Herpes Genitalis | Androgenic Alopecia | Hypertension, Renovascular | Ichthyosis | LMNA-related Congenital Muscular Dystrophy | Demyelinating Diseases | Micropenis | Chordoid Glioma | Lichen Planus | Corticobasal Syndrome | Nephroblastoma | Congenital Myasthenic Syndrome | Proteus Syndrome | Melnick-Needles Syndrome | Carbamoyl Phosphate Synthetase I Deficiency | Hereditary Inclusion Body Myopathy | Spondyloepiphyseal Dysplasia Tarda, X-linked | Cartilage Disorders | Joubert Syndrome | Gigantism | Keratopathy | Vertigo | Pierre Robin Syndrome | Gray Platelet Syndrome | Thrombocythemia, Essential | Ectodermal Dysplasia | Charcot-Marie-Tooth Disease Type 2T | Reflex Epilepsy | Facioscapulohumeral Muscular Dystrophy Type 2 | Succinic Semialdehyde Dehydrogenase Deficiency | Bietti Crystalline Dystrophy | Kaposi Sarcoma | Essential Fructosuria | COACH Syndrome | Congenital Torticollis | Benign Hereditary Chorea | Hepatitis | Gout | Mohr-Tranebjaerg Syndrome | Waardenburg Syndrome Type 2A | Discoid Lupus Erythematosus | Analgesia | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Niemann-Pick Disease | Primary Erythromelalgia | Reticular Dysgenesis | Osteonecrosis | Aromatic L-amino Acid Decarboxylase Deficiency | Hypohidrotic Ectodermal Dysplasia, X-linked | Familial Mediterranean Fever | Lymphangioleiomyomatosis | Seizures-scoliosis-macrocephaly Syndrome | Abetalipoproteinemia | Sleep Apnea, Central | Systemic Lupus Erythematosus | Vascular Calcification | Binge Eating Disorder | Noonan Syndrome-like Disorder With Loose Anagen Hair | Lentigo | Pulverulent Zonular Cataract | Paraganglioma | Uterine Leiomyoma | Brenner Tumor | Encephalopathy | Axenfeld-Rieger Syndrome | Tinea Versicolor | Martsolf Syndrome | Primary Progressive Aphasia | Ileitis | Agammaglobulinemia | Sitosterolemia | Hereditary Folate Malabsorption | Dysthymia | Seborrheic Dermatitis | Hyperostosis | Leiomyosarcoma | Barrett Esophagus | Pregnancy, Ectopic | Hypercholesterolemia | Meckel-Gruber Syndrome | Pontocerebellar Hypoplasia Type 2 | Pyruvate Kinase Deficiency | Bernard-Soulier Syndrome | Alpha-mannosidosis | Familial Dysautonomia | Spondyloarthritis | Low Phospholipid Associated Cholelithiasis | Wiedemann-Steiner Syndrome | Glycogen Storage Disease Type 6 | Rotor Syndrome | Small Lymphocytic Lymphoma | Tetanus | Sporadic Inclusion Body Myositis | Familial Isolated Hyperparathyroidism | Anxiety Disorders | Cardiac Arrest | Microvillus Inclusion Disease | Short-chain Acyl-CoA Dehydrogenase Deficiency | Walker-Warburg Syndrome | Aplastic Anemia | Cri-du-chat Syndrome | Trimethylaminuria | Filariasis | Adult Polyglucosan Body Disease | Pneumonia, Viral | Nager Acrofacial Dysostosis | Myofibrillar Myopathy | Antiphospholipid Syndrome | Brachydactyly | Osteogenesis Imperfecta Type V | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Kernicterus | Meningitis | Pure Autonomic Failure | Lymphoma | Juvenile Myoclonic Epilepsy | Alpha-thalassemia Myelodysplasia Syndrome | Transthyretin-related Amyloidosis | Pemphigoid | Generalized Epilepsy And Paroxysmal Dyskinesia | Paternal Uniparental Disomy Of Chromosome 14 | Schistosomiasis | Chronic Beryllium Disease | Periventricular Leukomalacia | Hyperferritinemia-cataract Syndrome | Spasticity | Infantile Refsum Disease | Oculocutaneous Albinism Type 1 | Narcolepsy | Nail-Patella Syndrome | Spina Bifida | Acrodysostosis | Pyruvate Decarboxylase Deficiency | Sulfite Oxidase Deficiency | Corneal Ulcer | Familial Pheochromocytoma-paraganglioma | DICER1 Syndrome | Shock, Cardiogenic | Measles | Pseudohypoparathyroidism Type 2