Ichthyosis

About the Disease
Ichthyosis, also known as ichthyoses, is related to ichthyosis, congenital, autosomal recessive 4b and autosomal recessive congenital ichthyosis, and has symptoms including trichorrhexis invaginata An important gene associated with Ichthyosis is TGM1 (Transglutaminase 1), and among its related pathways/superpathways are Keratinization and Prostaglandin 2 biosynthesis and metabolism FM. The drugs Ustekinumab and Emollients have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and lymph node, and related phenotypes are homeostasis/metabolism and growth/size/body region

Common Targets
RARA | PHGDH | SPINK5 | FLG | ST14 | LORICRIN | PIGL | KRT1 | TGM1 | KRT2 | ALDH3A2 | ALOXE3 | SDR9C7 | ELOVL4 | ASPRV1 | PRKCH | Serine protease (nonspecified subtype) | CYP4F22 | KRT9 | KRT10 | CLDN10 | ALOX12B | STS | Retinoid acid receptor (nonspecified subtype) | GTF2H5 | RORB | PSAT1 | ABHD5 | IL1RL2 | CDSN | PSPH | PLIN1 | NIPAL4 | LIPN | RARG | ANTXR2 | MTHFR | PNPLA1 | ABCA12 | Interleukin 17 (nonspecified subtype) | GJB2 | SREBF1 | SLC27A4 | MBTPS2 | VDR

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