Localized Scleroderma

About the Disease
Localized Scleroderma, also known as morphea, is related to scleroderma, familial progressive and facial hemiatrophy, and has symptoms including exanthema and pruritus. An important gene associated with Localized Scleroderma is MMP1 (Matrix Metallopeptidase 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Lidocaine and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and skeletal muscle, and related phenotypes are thickened skin and arthralgia

Common Targets
IL1B | TBX21 | IFNG | IL2 | STAT4 | G3576 | TGFB1 | MIF | IL6R | GATA3 | FGFR2 | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | CNR2 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CNR1 | G3569 | G7124

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