Malignant Melanoma

About the Disease
Melanoma, Cutaneous Malignant 1, also known as familial melanoma, is related to melanoma, cutaneous malignant 9 and skin melanoma. An important gene associated with Melanoma, Cutaneous Malignant 1 is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are "Cell Cycle, Mitotic" and Endometrial cancer. The drugs BCG vaccine and Vemurafenib have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and lymph node, and related phenotypes are nevus and melanoma

Common Targets
TXNL1 | MSH2 | G238 | TNFRSF9 | APC | CHEK2 | MAGEA3 | G596 | MLANA | KDR | XRCC1 | CTNNB1 | CRBN | G472 | Cyclin B (nonspecified subtype) | Protein farnesyltransferase | DPYD | CDK4/Cyclin D1 | ABL1 | DNA-Directed DNA Polymerase Complex | G3845 | MC1R | XPC | Melanin | G4089 | DCAF15 | G2335 | HFE | CDK2 | G7015 | LOC107987026 | SMO | ILKAP | FGFR2 | CTAG1A | HDAC2 | HOXB13 | HRAS | G595 | G1/S-specific cyclin-E (nonspecified subtype) | TGFB1 | CA1 | NRAS | MITF | TRPC5 | FLACC1 | LAG3 | TYR | Integrin Receptor (nonspecified subtype) | G5133 | TNFRSF18 | G5728 | CD3 Complex (T Cell Receptor Complex) | IL4R | CDK4 | KIT | HLA-B | Glutamate Transporter (nonspecified subtype) | CDK9/Cyclin T1 | DDR2 | BRCA2 | BCR | Chloride channel (nonspecified subtype) | MAP2K1 | WEE1 | IL-4 receptor | PMEL | Integrin alpha5beta1 (VLA-5) receptor | G673 | CDK9 | EDNRB | IRF4 | TFAP2A | G142 | G1029 | CDK4/Cyclin D | PDGFRB | SYK | RUVBL1 | CCNT1 | HDAC1 | DCT | QPCT | Voltage-Gated Sodium Channel Complex | SATB1 | CYP2R1 | Cyclin D (nonspecified subtype) | Interferon alpha/beta Receptor (nonspecified subtype) | GPX3 | HLA-A | NADSYN1 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | TNFAIP3 | TLR2 | CDK1/Cyclin B | CDH2 | FLT4 | MX2 | IL1RAP | PVRIG | Sodium channel (nonspecified subtype) | Mitogen-Activated Protein Kinase (nonspecified subtype) | PDE2A | FLT1 | TGFB2 | CCNE1 | RAF1 | CLPTM1L | TEK | G7157 | Poly [ADP-ribose] polymerase (nonspecified subtype) | Glutaminase (nonspecified subtype) | DDR1 | RBL2 | CA2 | CA9 | PSMD11 | CTAG1B | MMP8 | TNFRSF4 | NOX3 | CDK2/Cyclin E | PDE5A | CA5B | TTC1 | TIGIT | Histamine Receptor (HR) (nonspecified subtype) | Tubulin | MMP2 | MAP2K2 | EEF1D | Cyclin-dependent kinase inhibitor (nonspecified subtype) | G5743 | MIR146A | TLR9 | RIPK3 | G4233 | SMARCB1 | CTLA4 | PIK3CA | CTXND2 | NADPH Oxidase Complex | TYRP1 | CYP1B1 | G2064 | G7124 | TGFB3 | PTPN11 | BIRC5 | PDGFRA | FLT3 | TFPI2 | RET | MGMT | IFNAR2 | GAS6 | LXN | Histone deacetylase (nonspecified subtype) | G5243 | CDK1 | NADPH Oxidase (nonspecified subtype) | CA4

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