Leber Hereditary Optic Neuropathy

About the Disease
Leber Hereditary Optic Neuropathy, Modifier of, also known as leber hereditary optic neuropathy, is related to mitochondrial complex i deficiency, nuclear type 1 and leber optic atrophy and dystonia, and has symptoms including ataxia and static tremor. An important gene associated with Leber Hereditary Optic Neuropathy, Modifier of is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are Metabolism and "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.". The drugs Curcumin and Bezafibrate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and brain, and related phenotypes are mitochondrial respiratory chain defects and slow decrease in visual acuity

Common Targets
PTGS1 | TRNS1 | Lipoxygenase (nonspecified subtype) | COX3 | RNR2 | TRNS2 | TRNT | ICAM1 | ME1 | NDUFS2 | ND1 | Neurotrophic Factor (nonspecified subtype) | CYTB | JMJD1C | Histone acetyltransferase (HAT) (nonspecified subtype) | NF-kappaB (NFkB) | ND2 | MIR181B1 | EPO | G6PC1 | ND3 | NOX3 | AP-1 Transcription Factor Complex | TTN | TRNE | G1786 | ND4 | MIR4448 | NADPH Oxidase Complex | ATP6 | MIR181A1 | ND4L | NADPH Oxidase (nonspecified subtype) | OPA1 | G595 | HCAR2 | ND5 | ATP8 | TRNL1 | G4780 | MCAT | PARL | PPARA | Calcium channel (nonspecified subtype) | TRNL2 | G1956 | COX1 | ND6 | DNAH10 | DNAJC30 | PRICKLE3 | TRNP | GSR | G5743 | YARS2 | COX2 | RNR1 | TRNQ | OPA3

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