Nephroblastoma

About the Disease
Perlman Syndrome, also known as nephroblastomatosis, fetal ascites, macrosomia and wilms tumor, is related to wilms tumor 5 and wilms tumor 1, and has symptoms including abdominal pain An important gene associated with Perlman Syndrome is DIS3L2 (DIS3 Like 3'-5' Exoribonuclease 2), and among its related pathways/superpathways are Processing of Capped Intron-Containing Pre-mRNA and Translational Control. The drugs Cyclophosphamide and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include kidney, pancreatic islet and pancreas, and related phenotypes are macrocephaly and intellectual disability

Common Targets
ADGRB3 | DROSHA | SLC19A1 | WT1 | MTHFR | E2F7

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