CREST Syndrome

About the Disease
Limited Scleroderma, also known as limited cutaneous systemic sclerosis, is related to diffuse cutaneous systemic sclerosis and telangiectasis. An important gene associated with Limited Scleroderma is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Ebola virus infection in host and Genes associated with the development of rheumatoid arthritis. The drugs Ropivacaine and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and endothelial, and related phenotypes are autoimmunity and hypopigmented skin patches

Common Targets
HLA-DQB1 | SRSF6 | ALOX5AP | SSH2 | MECP2 | CD2 | HLA-DRB1 | LILRA3 | PSORS1C1 | HLA-DRB4 | TNIP1 | IRAK1 | ADRA2C

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