CREST Syndrome

About the Disease
Limited Scleroderma, also known as limited cutaneous systemic sclerosis, is related to diffuse cutaneous systemic sclerosis and telangiectasis. An important gene associated with Limited Scleroderma is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Ebola virus infection in host and Genes associated with the development of rheumatoid arthritis. The drugs Ropivacaine and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and endothelial, and related phenotypes are autoimmunity and hypopigmented skin patches

Common Targets
HLA-DQB1 | SRSF6 | ALOX5AP | SSH2 | MECP2 | CD2 | HLA-DRB1 | LILRA3 | PSORS1C1 | HLA-DRB4 | TNIP1 | IRAK1 | ADRA2C

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Other Diseases

Membranous Nephropathy | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Influenza | Odonto-onycho-dermal Dysplasia | Glycogen Storage Disease Type 0, Muscle | Autosomal Recessive Spastic Paraplegia Type 75 | Canavan Disease | Lymphangioleiomyomatosis | Paraplegia | Dwarfism | Dystonia Musculorum Deformans | Hereditary Neuropathy With Liability To Pressure Palsies | Transthyretin-related Amyloidosis | Facioscapulohumeral Muscular Dystrophy Type 2 | Veno-occlusive Disease | Bronchiolitis | Renal Hypouricemia | Combined Malonic And Methylmalonic Acidemia | Familial Isolated Hyperparathyroidism | Heavy Chain Disease | Nijmegen Breakage Syndrome | Lichen Planus | Withdrawal Syndrome | Methemoglobinemia Type IV | Schizoaffective Disorder | Renal Dysplasia | Chronic Idiopathic Myelofibrosis | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Limb Girdle Muscular Dystrophy | Osteogenesis Imperfecta | Meleda Disease | Creatine Deficiency Syndrome | Myopathy | Okihiro Syndrome | Fucosidosis | CDKL5 Deficiency Disorder | Primary Pigmented Nodular Adrenocortical Disease | Juvenile Xanthogranuloma | Keratitis-ichthyosis-deafness Syndrome | Pseudohypoparathyroidism Type 1A | Paraganglioma | Chronic Granulomatous Disease | Purpura, Thrombotic Thrombocytopenic | Congenital Poikiloderma | Liver Diseases | Schistosomiasis Mansoni | Sezary Syndrome | Tangier Disease | Rheumatoid Arthritis | Niemann-Pick Disease, Type A | Hyperthyroidism | Lymphoproliferative Disease, X-linked | 3-methylcrotonyl-CoA Carboxylase Deficiency | Greig Cephalopolysyndactyly Syndrome | Spinocerebellar Ataxia Type 5 | Bardet-Biedl Syndrome | VEXAS Syndrome | Polyradiculopathy | Tinea | Dentinogenesis Imperfecta | Pneumococcal Meningitis | Chronic Beryllium Disease | Inflammatory Linear Verrucous Epidermal Nevus | Sick Sinus Syndrome | Adenoma, Pituitary | Waardenburg Syndrome | Angiomyolipoma | Hemangioendothelioma | Facioscapulohumeral Muscular Dystrophy Type 1 | Vulvovaginitis | Hepatic Veno-occlusive Disease | Nemaline Myopathy 8 | Hypereosinophilic Syndrome | Thanatophoric Dysplasia | Cherubism | Megaloblastic Anemia | Osteoporosis-pseudoglioma Syndrome | Herpes Simplex Dermatitis | Blau Syndrome | Fibrosarcoma | Subcortical Band Heterotopia | Hepatitis A | Onchocerciasis | H Syndrome | Pyoderma Gangrenosum | Lissencephaly 2 | Glaucoma | Hemophilia | Adenoma, Villous | Hypertension, Portal | Blomstrand Osteochondrodysplasia | Priapism | Prune Belly Syndrome | Prostatitis | Urethritis | Leber Congenital Amaurosis | Creatine Deficiency Syndrome Due To AGAT Deficiency | Phosphoglycerate Dehydrogenase Deficiency | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Cenani-Lenz Syndactyly Syndrome | Ganglioglioma | Narcolepsy | Keratoacanthoma | Epilepsy, Generalized | Thrombasthenia | Enhanced S-cone Syndrome | Lymphoma, Mantle Cell | Diabetic Nephropathy | Cavitary Optic Disc Anomalies | Preaxial Polydactyly | Facioscapulohumeral Muscular Dystrophy | Primary Cutaneous Amyloidosis | Blue Nevus | Osteopathia Striata With Cranial Sclerosis | LRBA Deficiency | Congenital Dyserythropoietic Anemia | Purpura | Meier-Gorlin Syndrome | Hyperekplexia | Trigonocephaly | Molybdenum Cofactor Deficiency | Cholestasis, Intrahepatic | Pernicious Anemia | Otopalatodigital Syndrome Type 2 | Subacute Sclerosing Panencephalitis | Thyroid Dysgenesis | Major Depression | Autosomal Recessive Bestrophinopathy | Pain | Bronchitis | Pituitary Stalk Interruption Syndrome | Hydrolethalus Syndrome | Neuromyotonia | Histiocytic Sarcoma | Gastritis, Atrophic | Granular Corneal Dystrophy Type 1 | Proteasome-associated Autoinflammatory Syndrome 2 | Jacobsen Syndrome | Myelomeningocele | MELAS Syndrome | Primrose Syndrome | Carotid Artery Disease | Dystonia-parkinsonism, X-linked | Epidermodysplasia Verruciformis | Dengue Hemorrhagic Fever | Renal-hepatic-pancreatic Dysplasia | Porphyria, Acute Intermittent | Osteosclerosis | Cabezas Syndrome | Trimethylaminuria | Osteoglophonic Dysplasia | Discoid Lupus Erythematosus | Polycystic Kidney, Autosomal Recessive | Necrotizing Autoimmune Myopathy | Pyelonephritis | Non-Hodgkin Lymphoma | Epithelioid Hemangioma | Stromal Corneal Dystrophy | Agoraphobia | Pantothenate Kinase-associated Neurodegeneration | Benign Familial Infantile Seizures | Angioimmunoblastic T-cell Lymphoma | Brachydactyly | Vertigo | Pneumoconiosis | Hemophagocytic Lymphohistiocytosis | Diabetes Gestational | Antisocial Personality Disorder | Infantile Liver Failure Syndrome 1 | Adrenomyeloneuropathy | Sertoli Cell-only Syndrome | Riboflavin Transporter Deficiency Neuronopathy | Oligospermia | Primary Carnitine Deficiency | Dengue Shock Syndrome | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Juvenile Myoclonic Epilepsy | Pneumonia, Bacterial | Heimler Syndrome | Hypothalamic Obesity | Cardiomyopathy, Dilated, 1L | Hyperoxaluria | Pre-eclampsia | Erysipelas | Coronary Artery Disease | Motor Neuron Diseases | Papulopustular Rosacea | Succinic Semialdehyde Dehydrogenase Deficiency | Sorsby Fundus Dystrophy | Myotonic Disorders | Bloom Syndrome | Myeloid Leukemia | Neurodegeneration With Brain Iron Accumulation | Erythrokeratodermia Variabilis | Coenzyme Q10 Deficiency | Hepatitis E | Hypotrichosis Simplex | Hyperinsulinemic Hypoglycemia | Myoclonus-dystonia Syndrome | Hypersensitivity | Lewy Body Dementia | Lassa Fever | Keratitis | Bartsocas-Papas Syndrome | Pyloric Stenosis, Infantile Hypertrophic | Osmotic Demyelination Syndrome | Adenoid Cystic Carcinoma | Carney Triad | Long QT Syndrome Type 3 | Asplenia | Thyroiditis | Giant Cell Arteritis | Nicolaides-Baraitser Syndrome | Mucolipidosis Type III | Paraganglioma, Carotid Body | Fanconi Syndrome | Pierpont Syndrome | Schizophrenia, Paranoid | Traboulsi Syndrome | Charcot-Marie-Tooth Disease, Type 2C | Colitis | Miyoshi Myopathy | Marfan Syndrome | Acromegaly | Posterior Polar Cataract | Gastroenteritis | Congenital Torticollis | Epidermolytic Palmoplantar Keratoderma | Heterotopic Ossification | Pierson Syndrome | Pemphigus Vulgaris | Infantile Refsum Disease | Currarino Syndrome | Basal Ganglia Disease | Hypertension | Diabetic Encephalopathy | Ventricular Septal Defect | Infertility, Male | Crohn's Disease | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Enterocolitis, Necrotizing | Cerebellofaciodental Syndrome | Alopecia Areata | Diabetes Insipidus, Neurogenic | Exfoliative Dermatitis | Speech Disorders | 3-hydroxy-3-methylglutaric Aciduria | Treacher Collins Syndrome | Colitis, Lymphocytic | Ovarian Sex Cord-stromal Tumor | Scabies | Achondrogenesis | COACH Syndrome | Pompe Disease | Adenomyosis | Skin Fragility-woolly Hair Syndrome | Trachoma | Tietze Syndrome | Familial Hypobetalipoproteinemia | 3-M Syndrome | Diffuse Intrinsic Pontine Glioma | Angiosarcoma | Oral Lichen Planus | Allergic Contact Dermatitis | Histiocytosis | Graves Disease | Glomerulonephritis, Membranoproliferative | Prolymphocytic Leukemia | Pneumonia, Viral | Waardenburg Syndrome Type 1 | Melanoma, Uveal | Tic Disorder | Lung Diseases | Sleep Apnea | Acrodermatitis Enteropathica | Melanocytic Nevus | Pierre Robin Syndrome | Chondrodysplasia Punctata | Nephropathy | Glycogen Storage Disease Type 3 | Glomerulonephritis | Hypertrophy | Fetal Alcohol Syndrome | Kearns-Sayre Syndrome | Antenatal Bartter Syndrome Type 1 | Dyskeratosis Congenita | Ichthyosis, X-linked | Robinow Syndrome | Early Infantile Epileptic Encephalopathy 1 | Scleritis | Endometriosis | Postaxial Polydactyly | Conjunctivitis | Spinocerebellar Ataxia | Retinitis | Klinefelter Syndrome | Dominant Optic Atrophy | Pulmonary Vein Stenosis | Central Retinal Artery Occlusion | Combined Deficiency Of Factor V And Factor VIII | Corneal Dystrophy | Asthma, Exercise-induced | Autosomal Recessive Spastic Paraplegia Type 35 | VACTERL/VATER Association | Hepatopulmonary Syndrome | Triple A Syndrome | Autoimmune Polyendocrine Syndrome | Panniculitis | Iron Overload | Neuroma | Congenital Nystagmus | Pemphigus | Myocarditis | Cranioectodermal Dysplasia | Central Core Disease | Adult Polyglucosan Body Disease | Corneal Dystrophy And Perceptive Deafness | Mitochondrial Myopathy | Still Disease | Lymphedema-distichiasis Syndrome | Farber Disease | Tatton-Brown-Rahman Syndrome | Myofibromatosis | Myoclonic Atonic Epilepsy | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Vitelliform Macular Dystrophy | Alpha-thalassemia Myelodysplasia Syndrome | Burn-McKeown Syndrome | Cold Agglutinin Disease | Neuromuscular Disorders | Dystrophy, Cone-rod | Pouchitis | Multiple Epiphyseal Dysplasia | Myelofibrosis | X-linked Charcot-Marie-Tooth Disease | Charcot-Marie-Tooth Disease Type 2T | Congenital Heart Defects | Aromatic L-amino Acid Decarboxylase Deficiency | Cancer, Kidney | Benign Familial Pemphigus | Neutropenia | Immunoproliferative Disorders | Chromosome 9q34.3 Deletion Syndrome | Fuchs Heterochromic Iridocyclitis | Spitzoid Melanoma | Hypohidrotic Ectodermal Dysplasia, X-linked | Metatropic Dysplasia | Ileitis | Acute Chest Syndrome | Steel Syndrome | Fibromuscular Dysplasia | Cannabis Abuse | Waardenburg Syndrome Type 4 | Zygomycosis | Combined Pituitary Hormone Deficiency | Hemoglobinopathies | Sturge-Weber Syndrome | Craniolenticulosutural Dysplasia | Endocarditis | Choroideremia | Hyperandrogenemia | Syndactyly | WAGR Syndrome | Orotic Aciduria | Patent Ductus Arteriosus | Vitreoretinopathy, Proliferative | Ganglioneuroma | Xeroderma Pigmentosum Variant Type | Vitamin D Deficiency | Imerslund-Grasbeck Syndrome | Corticobasal Syndrome | Tuberculous Meningitis | Short-chain Acyl-CoA Dehydrogenase Deficiency | Olmsted Syndrome | Nanophthalmos | Dupuytren Disease | Glycogen Storage Disease Type 5 | Hypoglycemia | Neurofibromatosis-Noonan Syndrome | Cocaine-Related Disorders | Diabetes Insipidus, Nephrogenic | Hypotrichosis | Porencephaly | Osteochondroma | Epidermolytic Hyperkeratosis | Low Phospholipid Associated Cholelithiasis | Distal Myopathy | Mitochondrial Disease | Thrombophlebitis | Leukemia-lymphoma, Adult T-cell | Pneumonia, Mycoplasma | Unverricht-Lundborg Syndrome | Congenital Bile Acid Synthesis Defect | Gastric Atrophy | Vici Syndrome | Chiari Malformation Type I | Primary Torsion Dystonia | Myositis | Acute Kidney Injury | Torticollis