CREST Syndrome

About the Disease
Limited Scleroderma, also known as limited cutaneous systemic sclerosis, is related to diffuse cutaneous systemic sclerosis and telangiectasis. An important gene associated with Limited Scleroderma is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Ebola virus infection in host and Genes associated with the development of rheumatoid arthritis. The drugs Ropivacaine and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and endothelial, and related phenotypes are autoimmunity and hypopigmented skin patches

Common Targets
HLA-DQB1 | SRSF6 | ALOX5AP | SSH2 | MECP2 | CD2 | HLA-DRB1 | LILRA3 | PSORS1C1 | HLA-DRB4 | TNIP1 | IRAK1 | ADRA2C

Note: If you'd like to get a target analysis report for CREST Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of CREST Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Oculocutaneous Albinism Type 1 | Syndactyly | Epidermolytic Palmoplantar Keratoderma | Sepiapterin Reductase Deficiency | Tendinitis | Premenstrual Syndrome | Hereditary Spherocytosis | Ovarian Hyperstimulation Syndrome | Neuroma | Porphyria | Joubert Syndrome | Usher Syndrome Type III | Kashin-Beck Disease | Cleidocranial Dysplasia | Uveitis | Corticobasal Syndrome | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Depression | Parkinson Disease 6, Autosomal Recessive Early-onset | Wolfram Syndrome 2 | Costello Syndrome | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Triphalangeal Thumb-polysyndactyly Syndrome | Arteriovenous Malformations | Gyrate Atrophy Of The Choroid And Retina | Vertigo | Kabuki Syndrome 2 | Postpoliomyelitis Syndrome | Neurofibrosarcoma | Postpartum Depression | Rhabdomyosarcoma, Alveolar | Traboulsi Syndrome | Cholesteryl Ester Storage Disease | Cystitis | Hypertension, Essential | Pure Red Cell Aplasia | Progressive Familial Intrahepatic Cholestasis | Infertility, Male | Acute Coronary Syndrome | Brachydactyly | Hemosiderosis | Leukocyte Adhesion Deficiency Type 1 | Epidermolysis Bullosa Dystrophica | Vici Syndrome | Chloridorrhea, Congenital | Conjunctivitis, Allergic | Pityriasis Rubra Pilaris | Cardiac Sarcoidosis | Tinea Versicolor | Azoospermia | Migraine | Bipolar Disorder | Neuroleptic Malignant Syndrome | Stroke, Ischemic | Apraxia | Liddle Syndrome | Corneal Neovascularization | Conduct Disorder | Sialoadenitis | Lennox-Gastaut Syndrome | Gaucher Disease | Twin-to-twin Transfusion Syndrome | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Renal Medullary Carcinoma | Myelitis | Fukuyama Congenital Muscular Dystrophy | Occipital Neuralgia | Autoimmune Polyendocrinopathy Syndrome Type I | Left Ventricular Noncompaction | Pituitary Dwarfism | Ophthalmoplegia | Osteoarthritis | Bare Lymphocyte Syndrome | Multiple Sclerosis | Multiple System Atrophy | Coffin-Siris Syndrome | Malignant Fibrous Histiocytoma | Feingold Syndrome | Congenital Dyserythropoietic Anemia Type 4 | Hypercholesterolemia | Generalized Epilepsy And Paroxysmal Dyskinesia | Peritonitis | Sclerocornea | Bernard-Soulier Syndrome | Branchiootorenal Syndrome | Benign Familial Neonatal Convulsions | Diabetic Encephalopathy | Early Infantile Epileptic Encephalopathy | Retinitis Pigmentosa 3 | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Benign Familial Infantile Seizures | Diffuse Palmoplantar Keratoderma | Lymphoma | Osteonecrosis Of The Jaw | Achondrogenesis | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Spondylolisthesis | Cabezas Syndrome | Chondrodysplasia Punctata 2, X-linked Dominant | Nephroblastoma | Lyme Disease | Bietti Crystalline Dystrophy | Schizophrenia, Paranoid | Tardive Dyskinesia | Nephropathy | Pericarditis | Birt-Hogg-Dube Syndrome | Pseudohypoaldosteronism | Pulmonary Alveolar Microlithiasis | Meconium Ileus | Toxic Epidermal Necrolysis | Diabetes Type 2 | Oculocutaneous Albinism Type 4 | Glycogen Storage Disease Type 1a | Wolman Disease | Rosacea | Tangier Disease | Gynecomastia | Acute Anterior Uveitis | GLUT1 Deficiency Syndrome | Benign Familial Pemphigus | Macrodactyly | Cystinosis | Fraser Syndrome | Focal Dermal Hypoplasia | Specific Granule Deficiency | Rubeosis Iridis | Multiple Myeloma | Globozoospermia | Aneurysm, Thoracic Aortic | Cartilage Disorders | Hypospadias | Brenner Tumor | Myhre Syndrome | Palmoplantar Keratoderma | Disseminated Superficial Actinic Porokeratosis | Burn-McKeown Syndrome | Early Infantile Epileptic Encephalopathy 28 | Nijmegen Breakage Syndrome | Keratoacanthoma | Benign Hereditary Chorea | Lafora Disease | Eczema | Cancer, Bladder | Chronic Myelomonocytic Leukemia | Pain | Strabismus | Neurotoxicity | Chudley-McCullough Syndrome | Schizotypal Personality Disorder | Carpal Tunnel Syndrome | Geleophysic Dysplasia | Glutathione Synthetase Deficiency | Thin Basement Membrane Disease | Charcot-Marie-Tooth Disease, Type 1A | Hypoproteinemia, Hypercatabolic | Spinocerebellar Ataxia Type 5 | Pyruvate Kinase Deficiency | Epidermolytic Ichthyosis, Annular | Ameloblastic Carcinoma | Scapuloperoneal Myopathy, X-linked Dominant | Sturge-Weber Syndrome | Ganglioneuroma | Swine Influenza | Tetraplegia | Pulverulent Zonular Cataract | Budd-Chiari Syndrome | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Autonomic Nervous System Disorders | Chorea | Porphyria, Acute Intermittent | Granular Corneal Dystrophy | Retinopathy, Diabetic | Hyperlipidemia Type V | Atopy | Multisystemic Smooth Muscle Dysfunction Syndrome | Mood Disorder | Sitosterolemia | Gilbert Syndrome | Multicystic Renal Dysplasia | Allan-Herndon-Dudley Syndrome | Acromicric Dysplasia | Osteopathia Striata With Cranial Sclerosis | Large Granular Lymphocytic Leukemia | Hereditary Elliptocytosis | Primary Hyperoxaluria Type 3 | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Congenital Aniridia | Arterial Tortuosity Syndrome | Basal Ganglia Cerebrovascular Disease | Pterygium | Periodontitis | Giant Cell Arteritis | Autism | Corneal Ulcer | Martsolf Syndrome | Greig Cephalopolysyndactyly Syndrome | Panuveitis | Bardet-Biedl Syndrome | Hepatitis E | Congenital Stationary Night Blindness | Congenital Disorders Of Glycosylation | Malaria, Cerebral | Gray Platelet Syndrome | Hypersomnia | Keratoconus | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Low Phospholipid Associated Cholelithiasis | Chordoma | Anti-NMDA Receptor Encephalitis | Larsen Syndrome | Meningeal Melanocytoma | Vitamin K Deficiency | Cholangitis | Auriculocondylar Syndrome | Spinal Cord Diseases | Nephrotic Syndrome | Tyrosinemia Type 2 | Anxiety Disorders | Speech Disorders | Basal Cell Nevus Syndrome | Meckel-Gruber Syndrome | Dyggve-Melchior-Clausen Disease | Irritable Bowel Syndrome | 3-methylcrotonyl-CoA Carboxylase Deficiency | Split Hand-foot Malformation | Familial Partial Lipodystrophy | Chronic Lymphocytic Leukemia | Demyelinating Diseases | Erdheim-Chester Disease | Gastroenteritis, Eosinophilic | Leiomyosarcoma | Adult Polyglucosan Body Disease | Dystonia-parkinsonism, X-linked | Bacterial Meningitis | Osteogenesis Imperfecta Type II | Eosinophilic Asthma | Ocular Albinism Type 1 | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Congenital Nystagmus | Osteitis | Glycogen Storage Disease | Cockayne Syndrome | Ectopia Lentis, Isolated, Autosomal Recessive | Persistent Mullerian Duct Syndrome | Parkinsonism | Hyperlipidemia | LEOPARD Syndrome | Nephritis, Interstitial | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Focal Cortical Dysplasia Type 2 | Endometrial Hyperplasia | Schizoaffective Disorder | Epidermolytic Hyperkeratosis | Epidermolysis Bullosa Simplex, Generalized | Sponastrime Dysplasia | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Cholera | Hyperglycemia | Osteogenesis Imperfecta Type IV | Primary Progressive Nonfluent Aphasia | Sarcoma, Ewing | Vascular Calcification | Trigonocephaly | Glutaric Aciduria Type 3 | Congenital Heart Block | Arthritis, Reactive | Recurrent Respiratory Papillomatosis | Gestational Trophoblastic Disease | Polycystic Kidney, Autosomal Dominant | Autonomic Neuropathy | Erythropoietic Protoporphyria | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Ornithine Transcarbamylase Deficiency | Xeroderma Pigmentosum Variant Type | Hypertension, Renal | Autism Spectrum Disorders | Cellulitis | Hereditary Pyropoikilocytosis | Botulism | Spinocerebellar Ataxia Type 23 | Alpha-thalassemia Myelodysplasia Syndrome | Vitiligo | Withdrawal Syndrome | Hereditary Neuropathy With Liability To Pressure Palsies | Agnathia-Otocephaly Complex | Tenosynovial Giant Cell Tumor | Chronic Idiopathic Myelofibrosis | Familial Hypertrophic Cardiomyopathy | Pleurisy | Smith-Magenis Syndrome | Aldosteronism | Goiter, Nodular | Urethritis | Hamartoma | Granuloma Annulare | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Hepatitis C, Chronic | Hereditary Coproporphyria | Melnick-Needles Syndrome | Cerebellar Ataxia, Cayman Type | Basal Ganglia Disease, Biotin-responsive | Episodic Ataxia | Cohen Syndrome | Menkes Disease | Axenfeld-Rieger Syndrome | Polyradiculopathy | Fibrillation, Atrial | Leukemia-lymphoma, Adult T-cell | Central Retinal Artery Occlusion | GAPO Syndrome | Creutzfeldt-Jakob Disease | Polymyositis | Meier-Gorlin Syndrome | Non-proliferative Diabetic Retinopathy | Thalassemia, Beta | Distal Myopathy 2 | Chylomicron Retention Disease | Oligospermia | Membranous Nephropathy | Glanzmann Thrombasthenia | HANAC Syndrome | Stromal Corneal Dystrophy | Von Willebrand Disease | Glycogen Storage Disease Type 0 | Charcot-Marie-Tooth Disease Type 2T | Thrombophilia | Cardiospondylocarpofacial Syndrome | Congenital Bile Acid Synthesis Defect | Perry Syndrome | Adenoma, Pituitary | Senior-Loken Syndrome | Carcinoma, Small Cell | Li-Fraumeni Syndrome | Chondrosarcoma | Juvenile Xanthogranuloma | SAPHO Syndrome | Glioma | Keratoconjunctivitis | Sorsby Fundus Dystrophy | Hemorrhoids | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Congenital Generalized Lipodystrophy | Behcet's Disease | Ependymoma | Growth Hormone Excess | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Posterior Polar Cataract | Prediabetes | Epidermolysis Bullosa Acquisita | Nemaline Myopathy 8 | Acute Lung Injury | Neurofibromatosis Type 1 | Teratozoospermia | Fowler's Syndrome | Syphilis | Adrenomyeloneuropathy | Papulopustular Rosacea | Rhabdomyosarcoma, Embryonal | Aneurysm, Abdominal Aortic | Cryptorchidism | Optic Neuritis | Arts Syndrome | Cluster Headache | Spinocerebellar Ataxia Type 17 | Hyperoxaluria | Anorectal Fistula | Limb Girdle Muscular Dystrophy | Sotos Syndrome | Pineoblastoma | Epidermolysis Bullosa Simplex | Infantile Spasm | Schaaf-Yang Syndrome | CDKL5 Deficiency Disorder | Hyperphenylalaninemia | Cheilitis | Periventricular Nodular Heterotopia | Central Core Disease | Short-chain Acyl-CoA Dehydrogenase Deficiency | Cystitis, Interstitial | Adenomatoid Tumor | Hemangioma | Oligoasthenoteratozoospermia | Stickler Syndrome | Metabolic Syndrome | Bursitis | Retinopathy Of Prematurity | Chondroma | Antithrombin III Deficiency | Glioblastoma | Cold-induced Sweating Syndrome | Dyslexia | Neurofibromatosis Type 2 | Infantile Refsum Disease | Meningitis | Neurocutaneous Melanocytosis | Charcot-Marie-Tooth Disease Type 4E | Vasculitis | McKusick Type Metaphyseal Chondrodysplasia