Hemorrhage

About the Disease
Bleeding Disorder, Platelet-Type, 11, also known as glycoprotein vi deficiency, is related to thrombocytopenic purpura, autoimmune and purpura, and has symptoms including abdominal pain, angina pectoris and chest pain. An important gene associated with Bleeding Disorder, Platelet-Type, 11 is GP6 (Glycoprotein VI Platelet), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Probucol and Glycerin have been mentioned in the context of this disorder. Affiliated tissues include brain, placenta and whole blood, and related phenotypes are epistaxis and bruising susceptibility

Common Targets
CYP2C19 | gamma-Secretase | VWF | F9 | BMP4 | MAOA | COMT | ITGA2 | GATA1 | G23411 | VKORC1 | MC2R | ESAM | PDGFD | NR1I2 | G3630 | AKR1B1 | F10 | XDH | OXT | G5243 | SELP | MTHFR | F2 | CES1 | SERPINE1 | NOS3 | G1956 | PLG | PLAT | MMP2 | CYP3A5 | FASN | STS | JAM3 | PDE5A | Serine protease (nonspecified subtype) | F5 | ORM1 | CYP2J2 | PKM | CFTR | GGCX | CYP2C9 | PON1 | SLCO1B1 | JAK2 | ITGB3 | OR4D2 | PRR5L | APOE | F2RL3 | HNF4A | GP6 | CYP4F2 | F11 | APOB | KLKB1 | LOC101927314 | EPHX1 | G472 | Arginase (nonspecified subtype) | NQO1 | F2R | OXTR | F7 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | DDAH2 | EPHA7 | LPA | FGG | SCN5A | TGFB1 | PRKG1 | PTGFR | DPYD | Vasopressin V1 Receptor (nonspecified subtype) | THBD | LTF | GALNT14 | AMP-activated protein kinase (AMPK) | F8 | Fibrinogen | ACE

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