Urticaria

About the Disease
Urticaria, also known as urticaria nos, is related to physical urticaria and chronic spontaneous urticaria, and has symptoms including abdominal pain, chest pain and constipation. An important gene associated with Urticaria is F12 (Coagulation Factor XII), and among its related pathways/superpathways are NF-kappaB Signaling and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Levoleucovorin and Dapsone have been mentioned in the context of this disorder. Affiliated tissues include upper dermis, skin and thyroid, and related phenotype is immune system.

Common Targets
TEC | CCR10 | IL1RN | CCN1 | DUSP3 | DNASE1L3 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | PDE4B | NR1H2 | DAB1 | CYSLTR1 | ORAI1 | PPARA | ADRA1A | FLG | NAT2 | PLA2G4A | HLA-B | SIGMAR1 | ALOX12 | BMX | SIGLEC8 | HRH2 | IGHE | PPP3R2 | SLC6A2 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | PPP3CC | PPID | HTR2B | HDC | IL-4 receptor | G7124 | HLA-A | SYK | ITK | NR3C1 | G3630 | TSLP | UGT1A6 | 15-Lipoxygenase (nonspecified subtype) | ADORA3 | G367 | IL1R1 | MS4A1 | PTGER4 | ADGRE2 | HAVCR1 | IL5 | PTGDR2 | VDR | SPNS1 | TNFRSF11A | CALCRL | Immunoglobulin E (IgE) | CD200R1 | PDE6D | PLCG1 | AOC1 | Serine protease (nonspecified subtype) | HIGD1B | SLC6A4 | CCL17 | IL25 | IL5RA | HRH1 | CD300A | GOSR2 | CYP2C9 | PPP3CB | PPP3R1 | ALB | CRLF2 | alpha1-Adrenoceptor (nonspecified subtype) | C5AR1 | Histamine Receptor (HR) (nonspecified subtype) | CD28 | LAT | TLR6 | TBXA2R | MRGPRX2 | IL4 | LTC4S | G3569 | ALOX5 | CRP | GLP1R | HLA-C | IL13 | FCER1A | G3576 | HRH4 | EFTUD2 | TXK | PTAFR | TLR1 | ALOX15 | PDE4D | KIT | HNMT | RORC | Protein Phosphatase 2B | MC1R | PPIA | HRH3 | BTK

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