Hypocalcemia

About the Disease
Hypocalcemia, Autosomal Dominant 1, also known as autosomal dominant hypocalcemia, is related to hyperparathyroidism, neonatal severe and hypophosphatemic rickets, autosomal dominant, and has symptoms including muscle cramp, seizures and carpopedal spasm. An important gene associated with Hypocalcemia, Autosomal Dominant 1 is CASR (Calcium Sensing Receptor), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Zoledronic acid and Foscarnet have been mentioned in the context of this disorder. Affiliated tissues include kidney, eye and brain, and related phenotypes are emotional lability and anxiety

Common Targets
CASR | AP2S1 | TRPM6 | PTPN22 | PTH | GNA11 | Parathyroid Hormone Receptors (PTHR) (nonspecified subtype) | CLCN7

Note: If you'd like to get a target analysis report for Hypocalcemia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hypocalcemia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Episodic Ataxia Type 1 | Epidermolysis Bullosa Simplex, Localized | Cryptorchidism | Heart Failure | Chronic Thromboembolic Pulmonary Hypertension | Stargardt Disease | Spondyloepiphyseal Dysplasia Tarda, X-linked | Blepharitis | Cerebrotendinous Xanthomatosis | Sleep Apnea, Central | Heart Block | Gerstmann-Straussler-Scheinker Syndrome | TARP Syndrome | Arts Syndrome | Trimethylaminuria | Dysthymia | PASLI Disease | X-linked Charcot-Marie-Tooth Disease | Dysequilibrium Syndrome | Meckel-Gruber Syndrome | Amenorrhea | Paraganglioma | Brachydactyly | Peripheral Neuropathy | Cystitis, Interstitial | Vertebrobasilar Insufficiency | Sporadic Inclusion Body Myositis | Scabies | Hypotonia-cystinuria Syndrome | Congenital Myopathy | Pseudoexfoliation Syndrome | Nijmegen Breakage Syndrome | Hoyeraal-Hreidarsson Syndrome | Down Syndrome | Craniolenticulosutural Dysplasia | Swine Influenza | Diabetes Mellitus, Transient Neonatal | Hyperphenylalaninemia | Antenatal Bartter Syndrome Type 1 | Aplasia Cutis Congenita | LRBA Deficiency | Primary Carnitine Deficiency | Thrombocythemia, Essential | Hypertension, Essential | Multiple Sclerosis, Chronic Progressive | Cysticercosis | Arthritis, Reactive | Citrullinemia | Focal Dermal Hypoplasia | Liver Diseases | Scleroderma, Diffuse | Genitopatellar Syndrome | Currarino Syndrome | Goiter | Chanarin-Dorfman Syndrome | Ollier Disease | Inflammatory Myopathy | Atherosclerosis | Poirier-Bienvenu Neurodevelopmental Syndrome | Neuroendocrine Cancer | Periodontitis | Antithrombin III Deficiency | Familial Retinal Arterial Macroaneurysm | Myasthenia Gravis | Hypercholesterolemia | Pyelonephritis | 3-methylglutaconic Aciduria | Gynecomastia | Crigler-Najjar Syndrome | Combined Pituitary Hormone Deficiency | Partington Syndrome | Kindler Syndrome | PHARC Syndrome | Autosomal Recessive Bestrophinopathy | Robinow Syndrome | Cardiomyopathy, Dilated, 1L | Diabetic Macular Edema | Tardive Dyskinesia | Papillon-Lefevre Syndrome | Melnick-Needles Syndrome | Micropenis | Intracerebral Hemorrhage | Myelomeningocele | Microcephaly, Seizures, And Developmental Delay | Thalassemia, Beta | Waardenburg Syndrome | Heroin Dependence | Systemic Mastocytosis | Ependymoma | Pulverulent Zonular Cataract | Spinocerebellar Ataxia Type 1 | Strabismus | Exotropia | Learning Disability | Charcot-Marie-Tooth Disease Type 4D | Personality Disorders | Retinal Telangiectasia | Roberts Syndrome | Adenosine Deaminase 2 Deficiency | Fatty Aldehyde Dehydrogenase Deficiency | Colitis, Lymphocytic | Fundus Albipunctatus | Cirrhosis | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Addison Disease | Disseminated Superficial Actinic Porokeratosis | Herpes Simplex Dermatitis | Diabetes Insipidus, Nephrogenic | Myoclonic Atonic Epilepsy | Neuromyotonia | Cryopyrin-associated Periodic Syndromes | Pituitary Disorders | Pontocerebellar Hypoplasia Type 7 | Kawasaki Disease | Exocrine Pancreatic Insufficiency | Encephalopathy, Ethylmalonic | Bainbridge-Ropers Syndrome | Alopecia | Macrodactyly | Ganglioneuroma | Cholesteryl Ester Storage Disease | Aneurysm, Abdominal Aortic | Restless Legs Syndrome | Wiskott-Aldrich Syndrome | Narcolepsy | Hyperostosis | Fibronectin Glomerulopathy | Congestive Heart Failure | Hypersensitivity | Charcot-Marie-Tooth Disease, Type 2A | Glutathione Synthetase Deficiency | Campomelic Dysplasia | Spitz Nevus | Multicentric Carpotarsal Osteolysis Syndrome | Galactosialidosis | Tumoral Calcinosis | Myositis, Focal | Thrombasthenia | Conjunctivitis | Primary Progressive Nonfluent Aphasia | Rotor Syndrome | Pneumoconiosis | Creatine Deficiency Syndrome Due To AGAT Deficiency | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Familial Hypertrophic Cardiomyopathy | Meesmann Corneal Dystrophy | Hashimoto Thyroiditis | Necrotizing Autoimmune Myopathy | Pancytopenia | Oculocutaneous Albinism Type 1 | Chronic Granulomatous Disease | Tinea | Bronchitis | Obesity, Morbid | Angelman Syndrome | Hyperammonemia | Gastroschisis | Chloridorrhea, Congenital | Wolcott-Rallison Syndrome | Heterotaxy | Cutaneous Lupus Erythematosus | Menkes Disease | Inflammatory Myofibroblastic Tumor | Olmsted Syndrome | Porokeratosis | Fetal Alcohol Syndrome | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Trigonocephaly | Cellulitis | Perry Syndrome | Colitis, Microscopic | Chronic Idiopathic Myelofibrosis | Familial Hemiplegic Migraine | Xeroderma Pigmentosum Variant Type | Cyst | Intestinal Hypomagnesemia 1 | Centronuclear Myopathy | Nephropathy | Reye Syndrome | Woodhouse-Sakati Syndrome | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Dysferlinopathy | Proopiomelanocortin Deficiency | Schizotypal Personality Disorder | Meier-Gorlin Syndrome | Granular Corneal Dystrophy | Nephrotic Syndrome Type 1 | Apert Syndrome | Leber Congenital Amaurosis | Gout | Choroiditis | Dwarfism | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Charcot-Marie-Tooth Disease Type 2T | Camurati-Engelmann Disease | Spinocerebellar Ataxia Type 15 | Lymphomatoid Granulomatosis | Endometriosis | Bartter Syndrome | Carey-Fineman-Ziter Syndrome | Light Chain Amyloidosis | Agranulocytosis | Mandibuloacral Dysplasia With Type A Lipodystrophy | Sponastrime Dysplasia | Presbycusis | Nemaline Myopathy 8 | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | 3C Syndrome | Cerebral Cavernous Malformations | Hepatitis D | Astrocytoma, Anaplastic | Nasodigitoacoustic Syndrome | Osmotic Demyelination Syndrome | Phenylketonuria | Acute Anterior Uveitis | Borjeson-Forssman-Lehmann Syndrome | Sarcomatoid Carcinoma Of The Lung | Neutrophilia | Peyronie's Disease | Loeys-Dietz Syndrome | Chiari Malformation Type I | Keratitis | Mucolipidosis Type II | Scleroderma | Tangier Disease | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Gangliosidosis, GM1 | Familial Advanced Sleep Phase Syndrome | Neuroectodermal Tumors, Primitive | Richter's Syndrome | Giant Axonal Neuropathy | Hyperekplexia | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Canavan Disease | Inborn Errors Of Metabolism | Sorsby Fundus Dystrophy | Homocystinuria | Glycogen Storage Disease Type 6 | Osteomalacia | Papillorenal Syndrome | Mitochondrial Disease | Pyruvate Carboxylase Deficiency Disease | Gilbert Syndrome | Melanoma | Diarrhea | Marshall-Smith Syndrome | Gitelman Syndrome | Hyperkeratosis | Sandhoff Disease | Alzheimer Disease, Late Onset | GAPO Syndrome | Frontometaphyseal Dysplasia | Leukocyte Adhesion Deficiency Type 1 | Tenosynovial Giant Cell Tumor | HELLP Syndrome | Primary Sclerosing Cholangitis | Silver-Russell Syndrome | Spinocerebellar Ataxia Type 17 | Ocular Albinism Type 1 | Epidermolysis Bullosa Simplex, Generalized | Ligneous Conjunctivitis | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Polycystic Liver | Infantile Liver Failure Syndrome 1 | Astigmatism | Long QT Syndrome Type 1 | 3-hydroxy-3-methylglutaric Aciduria | Sick Sinus Syndrome 1 | Macular Corneal Dystrophy | Insulinoma | LEOPARD Syndrome | Myotonia | Omenn Syndrome | Interstitial Lung Diseases | Lathosterolosis | Sick Sinus Syndrome | Blepharophimosis Syndrome | Hereditary Spherocytosis | Infantile Nephropathic Cystinosis | Bethlem Myopathy | Panuveitis | Blastoma, Pleuropulmonary | Chronic Kidney Disease | Cone Dystrophy | Spinocerebellar Ataxia Type 20 | Autosomal Recessive Spastic Paraplegia Type 54 | Thyrotoxic Periodic Paralysis | Adenoid Cystic Carcinoma | Kernicterus | Esophageal Motility Disorders | Acrodysostosis | Desmosterolosis | Pyloric Stenosis, Infantile Hypertrophic | Metanephric Adenoma | Sarcosinemia | Potocki-Shaffer Syndrome | Bare Lymphocyte Syndrome | Anterior Segment Dysgenesis | Primary Progressive Aphasia | Vitamin A Deficiency | Paget's Disease Of The Breast | Thromboembolism | Pompe Disease | Wolfram Syndrome | Retinitis Pigmentosa 3 | Colitis, Collagenous | Schwartz-Jampel-Aberfeld Syndrome | Rash | Camptocormia | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Oguchi Disease-2 | Wolff-Parkinson-White Syndrome | Gastritis, Atrophic | Urea Cycle Disorder | Progressive Familial Intrahepatic Cholestasis Type 3 | Angioedema, Hereditary | Nephritis, Interstitial | Anorectal Malformations | Renal Oncocytoma | Porphyria | Orthostatic Intolerance | McLeod Syndrome | Pycnodysostosis | Hypoglycemia | Smoldering Myeloma | Sarcoidosis | Atrial Septal Defect | Noonan Syndrome | Glycogen Storage Disease | Postpartum Depression | Cutaneous Mastocytosis | Thrombophilia | Sturge-Weber Syndrome | Rosacea | Congenital Dyserythropoietic Anemia | Eosinophilia | Congenital Afibrinogenemia | Fibrosarcoma | Periventricular Nodular Heterotopia | Ameloblastic Carcinoma | Glycogen Storage Disease Type 0, Muscle | Portal Vein Thrombosis | Juvenile Hyaline Fibromatosis | Coronary Heart Disease | Neural Tube Defect | Proteasome-associated Autoinflammatory Syndrome 2 | Liver Failure, Acute Infantile | Acute Lung Injury | Dermatitis | Mumps | Proximal Symphalangism | Van Der Knaap Disease | Pemphigus | Cancer, Breast | Hypercholesterolemia, Familial | Pterygium | Chondrosarcoma | Fibrillation, Atrial | Adams-Oliver Syndrome | Hermansky-Pudlak Syndrome | Meningitis | Myoclonus-dystonia Syndrome | Schnitzler Syndrome | Birt-Hogg-Dube Syndrome | Cluster Headache | DiGeorge Syndrome | Hereditary Folate Malabsorption | Noonan Syndrome-like Disorder With Loose Anagen Hair | Tuberculosis | Neurofibromatosis Type 2 | Dystrophy, Cone-rod | Medulloblastoma | Diabetic Nephropathy | Huntington's Disease-like 2 | Schuurs-Hoeijmakers Syndrome | Lafora Disease | Albinism | Pineoblastoma | Ectopia Lentis, Isolated, Autosomal Recessive | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Methemoglobinemia | Keratosis, Actinic | Hyperkalemic Periodic Paralysis | Paracoccidioidomycosis | Ichthyosis Bullosa Of Siemens | Oculocutaneous Albinism | Spinocerebellar Ataxia Type 21 | Infertility | Cavitary Optic Disc Anomalies | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Evans Syndrome | Juvenile Polyposis | Majeed Syndrome | Schamberg Disease | Myopia | Blomstrand Osteochondrodysplasia | Sleep Disorder | Seborrheic Dermatitis | Facioscapulohumeral Muscular Dystrophy | Myocardial Infarction