Dent Disease

About the Disease
Dent Disease 1, also known as dent disease, is related to hypophosphatemic rickets, x-linked recessive and rickets, and has symptoms including bone pain An important gene associated with Dent Disease 1 is CLCN5 (Chloride Voltage-Gated Channel 5), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Hydrochlorothiazide and Antihypertensive Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and cortex, and related phenotypes are aminoaciduria and hematuria

Common Targets
Solute Carrier Family 12 (nonspecified subtype) | CFTR | CLCN5 | OCRL

Note: If you'd like to get a target analysis report for Dent Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Dent Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Acrodermatitis | Hypercalcemia | Demyelinating Diseases | Marinesco-Sjogren Syndrome | Barakat Syndrome | Multisystemic Smooth Muscle Dysfunction Syndrome | Esophagitis | Leukoplakia, Oral | Urticaria | Asthma, Nocturnal | Muckle-Wells Syndrome | Anosmia, Congenital | Inflammatory Myopathy | Vitiligo | Anorectal Fistula | Krabbe Disease | Arthropathy | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Tinea | Schnitzler Syndrome | 3-methylglutaconic Aciduria | Glycogen Storage Disease Type 1a | Myoclonus-dystonia Syndrome | Joubert Syndrome 2 | Erythropoietic Protoporphyria | Waardenburg Syndrome Type 2 | Schistosomiasis Mansoni | Pneumonia, Viral | Fetal Alcohol Syndrome | Blepharospasm | Dengue Hemorrhagic Fever | Stroke, Hemorrhagic | Neonatal Progeroid Syndrome | Abetalipoproteinemia | Sjogren Syndrome | Marshall-Smith Syndrome | Osteomalacia | McLeod Syndrome | Mountain Sickness | Osteogenesis Imperfecta Type II | Discoid Lupus Erythematosus | Hepatopulmonary Syndrome | Delirium | Down Syndrome | Mucolipidosis | Cholangitis | Mitochondrial Myopathy | Ichthyosis Hystrix, Curth-Macklin Type | Epicondylitis | Spinocerebellar Ataxia Type 14 | Polymyositis | Membranous Nephropathy | Behcet's Disease | Hydronephrosis | Castleman Disease | Choroiditis | Craniofacial Dysostosis | Wolfram Syndrome | Hepatitis E | Kashin-Beck Disease | Periodic Limb Movement Disorder | Multiple Sulfatase Deficiency | Shwachman-Bodian-Diamond Syndrome | Familial Exudative Vitreoretinopathy | Methemoglobinemia Type IV | Nance-Horan Syndrome | Macrophagic Myofasciitis | Autoimmune Hemolytic Anemia | Erectile Dysfunction | Patent Foramen Ovale | Myotonia | Diabetes | Hoyeraal-Hreidarsson Syndrome | Schaaf-Yang Syndrome | Extramammary Paget's Disease | Spondyloperipheral Dysplasia | Hyperthermia, Malignant | Disseminated Intravascular Coagulation | Combined Malonic And Methylmalonic Acidemia | Skin Papilloma | Medulloblastoma | Mastitis | Cutaneous Lupus Erythematosus | Zimmermann-Laband Syndrome | Limb Girdle Muscular Dystrophy | McKusick Type Metaphyseal Chondrodysplasia | Retinal Dystrophy | Long QT Syndrome Type 1 | Schuurs-Hoeijmakers Syndrome | ADNP Syndrome | Hairy Cell Leukemia | Autosomal Recessive Congenital Ichthyosis | Purpura, Thrombotic Thrombocytopenic | Subcortical Band Heterotopia | Farber Disease | Postpoliomyelitis Syndrome | Dermatitis Herpetiformis | Hepatitis D | Aceruloplasminemia | Proteasome-associated Autoinflammatory Syndrome 2 | Harlequin Ichthyosis | Acute Kidney Injury | Meningioma, Benign | Waardenburg Syndrome Type 4A | Pantothenate Kinase-associated Neurodegeneration | Multiple Sclerosis | Chordoma | Myositis, Focal | Focal Dermal Hypoplasia | Frank-ter Haar Syndrome | Pyruvate Decarboxylase Deficiency | Arts Syndrome | Hyperthyroidism | Angioedema | Oculopharyngeal Muscular Dystrophy | Light Chain Amyloidosis | Premenstrual Syndrome | Primary Torsion Dystonia | Dominant Optic Atrophy | Peyronie's Disease | Thyroid Hormone Resistance | Chondrosarcoma | Gestational Trophoblastic Disease | Asplenia | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Congenital Disorders Of Glycosylation Type II | Bacterial Meningitis | 3C Syndrome | Hyperekplexia | Adenoid Cystic Carcinoma | GNE Myopathy | Robinow Syndrome | Charcot-Marie-Tooth Disease Type 3 | Dysequilibrium Syndrome | Leprosy | Spinocerebellar Ataxia Type 31 | Cervicitis | Adult Polyglucosan Body Disease | Sclerocornea | Hashimoto Thyroiditis | Nephrosclerosis | Obesity | Coronary Heart Disease | Arteriosclerosis | Hypertensive Retinopathy | Aldosteronism | GAPO Syndrome | Esthesioneuroblastoma | Mosaic Variegated Aneuploidy Syndrome 2 | Familial Cerebral Amyloid Angiopathy | Periodontitis | Primary Hyperoxaluria Type 1 | Adrenal Insufficiency | Spinocerebellar Ataxia Type 13 | Rickets | Fibrosis | Triphalangeal Thumb-polysyndactyly Syndrome | Gerstmann-Straussler-Scheinker Syndrome | Endometriosis | Norrie Disease | Nicotine Dependence | Supravalvular Aortic Stenosis | Apert Syndrome | Thyroiditis, Autoimmune | Kaposi Sarcoma | Esotropia | Encephalocele | Lipid Storage Diseases | Renal Medullary Carcinoma | Osteogenesis Imperfecta Type VI | Stevens-Johnson Syndrome | Pathological Gambling | Intestinal Tuberculosis | Hypervalinemia | Myasthenia Gravis | Pancytopenia | Tyrosine Hydroxylase Deficiency | Hemosiderosis | Influenza | Facioscapulohumeral Muscular Dystrophy Type 1 | Aromatic L-amino Acid Decarboxylase Deficiency | Tricho-hepato-enteric Syndrome | Porphyria Cutanea Tarda | Crigler-Najjar Syndrome | Hyperuricemic Nephropathy, Familial Juvenile | Acute Leukemia | Cavitary Optic Disc Anomalies | Alpha-thalassemia Myelodysplasia Syndrome | Anemia | Tumoral Calcinosis | Adrenoleukodystrophy, X-linked | Fuchs Dystrophy | Pleurisy | MIRAGE Syndrome | Granular Corneal Dystrophy Type 1 | Optic Nerve Hypoplasia, Bilateral | Endometritis | Mohr-Tranebjaerg Syndrome | Subacute Sclerosing Panencephalitis | Dyslipidemia | Mesothelioma, Malignant | Bursitis | Heart Failure | Rhinitis | Endometrial Hyperplasia | DOCK8 Immunodeficiency Syndrome | Colitis, Microscopic | Erythema Nodosum | Charcot-Marie-Tooth Disease, Type 2A | Anorectal Malformations | Neuromyelitis Optica | Proximal Symphalangism | Choriocarcinoma | Cockayne Syndrome | Focal Facial Dermal Dysplasia | Klippel-Feil Syndrome | Otitis Media | Cancer, Lung | Carbamoyl Phosphate Synthetase I Deficiency | Nephrocalcinosis | Primrose Syndrome | Tremor | Cerebellofaciodental Syndrome | Seizures | Charcot-Marie-Tooth Disease, Type 2C | Citrullinemia | Schizencephaly | Central Retinal Artery Occlusion | Dermatofibrosarcoma | Chronic Leukemia | Prurigo Nodularis | Analgesia | Lymphopenia | Salla Disease | Hypohidrotic Ectodermal Dysplasia | Acne Vulgaris | Uveitis | Ganglioneuroma | X-linked Charcot-Marie-Tooth Disease | Angiodysplasia | Platelet Disorders | Beckwith-Wiedemann Syndrome | Sickle Cell Anemia | Stiff-man Syndrome | Anodontia | Charcot-Marie-Tooth Disease Type 4B1 | Encephalopathy, Ethylmalonic | Chronic Lymphocytic Leukemia | Atelosteogenesis Type 1 | Hydrocephalus | Leber Congenital Amaurosis | Spinal Muscular Atrophy Type 3 | Chiari Malformation Type I | Mitochondrial Encephalomyopathy | Iron Metabolism Disorders | Glycogen Storage Disease Type 9 | Cancer, Kidney | Johanson-Blizzard Syndrome | Multicentric Carpotarsal Osteolysis Syndrome | Cirrhosis | Dementia | Conn Syndrome | Asthma | Perivascular Epithelioid Cell Tumor | Coenzyme Q10 Deficiency | Hemolytic Uremic Syndrome, Atypical | Inflammatory Joint Disease | Parkinson's Disease | Hypertensive Nephropathy | Idiopathic Pulmonary Fibrosis | Mitochondrial DNA Depletion Syndrome 13 | Cold Agglutinin Disease | LMNA-related Congenital Muscular Dystrophy | Phosphoglycerate Dehydrogenase Deficiency | Dementia, Vascular | Smith-Lemli-Opitz Syndrome | Primary Biliary Cholangitis | Fatty Aldehyde Dehydrogenase Deficiency | Trachoma | Placenta Previa | Colorectal Adenoma | Lesch-Nyhan Syndrome | Osteosclerosis | Oligodendroglioma | Thrombosis | Kohlschutter-Tonz Syndrome | Tendinopathy | Sezary Syndrome | Small Lymphocytic Lymphoma | Lathosterolosis | Chylothorax, Congenital | Cryoglobulinemia | Communication Disorders | Glycogen Storage Disease Type 0, Muscle | Microcephaly, Seizures, And Developmental Delay | Anxiety Disorders | Acute Tubular Necrosis | Cold-induced Sweating Syndrome | Pachyonychia Congenita | Hemimegalencephaly | Infantile Refsum Disease | Lipodystrophy | Vascular Cognitive Impairment | Usher Syndrome | Zollinger-Ellison Syndrome | Cutaneous Angiosarcoma | Constipation | Creatine Deficiency Syndrome Due To AGAT Deficiency | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Multiple Hamartoma Syndrome | Metabolic Diseases | Heterotaxy | Ameloblastoma | Hidradenitis Suppurativa | Iron Overload | Ophthalmia, Sympathetic | Intracranial Hypertension | Apraxia | Melanoma | Situs Inversus | Asphyxia Neonatorum | Pneumonia, Mycoplasma | Enterocolitis, Necrotizing | Coma | Scleroderma | Leukemia-lymphoma, Adult T-cell | Pancreatitis | Corneal Neovascularization | Juvenile Xanthogranuloma | Cannabis Abuse | Recurrent Respiratory Papillomatosis | Benign Familial Pemphigus | Familial Retinal Arterial Macroaneurysm | Senior-Loken Syndrome | Melanocytic Nevus | Syncope | Sialidosis Type I | Noonan Syndrome | Rheumatic Heart Disease | Metatropic Dysplasia | Blue Nevus | Corneal Dystrophies, Hereditary | Angelman Syndrome | Neurofibroma, Plexiform | Sarcoidosis | Metachondromatosis | Niemann-Pick Disease, Type C | Myocarditis | Behavioral Variant Of Frontotemporal Dementia | Arteriovenous Malformations | Leukemia | Anthrax | Macrodactyly | Kernicterus | Familial Partial Lipodystrophy | Ventricular Septal Defect | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Cerebral Amyloid Angiopathy | Exotropia | Preaxial Polydactyly | Glutaric Aciduria Type 2 | Alzheimer Disease, Late Onset | Fibromyalgia | Renal-hepatic-pancreatic Dysplasia | Colitis, Collagenous | Paracoccidioidomycosis | Intracerebral Hemorrhage | Blepharo-cheilo-odontic Syndrome | Chorioretinitis | Pseudo-pseudohypoparathyroidism | Smith-Kingsmore Syndrome | Compartment Syndrome | Silicosis | Chronic Neutrophilic Leukemia | Donnai-Barrow Syndrome | Clouston Hidrotic Ectodermal Dysplasia | Dystonia-parkinsonism, X-linked | Nicotine Addiction | Acne | Long QT Syndrome Type 2 | Paronychia | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Erythema Multiforme | Sponastrime Dysplasia | Congenital Afibrinogenemia | Neurocysticercosis | Chediak-Higashi Syndrome | Primary Cutaneous Amyloidosis | Dwarfism | Diffuse Palmoplantar Keratoderma | Mitochondrial DNA Depletion Syndrome | Alazami Syndrome | Axenfeld-Rieger Syndrome | Pheochromocytoma | Retinal Degeneration | Liddle Syndrome | Lipoma | Congenital Muscular Dystrophy | Persistent Hyperplastic Primary Vitreous | Congestive Heart Failure