Dent Disease

About the Disease
Dent Disease 1, also known as dent disease, is related to hypophosphatemic rickets, x-linked recessive and rickets, and has symptoms including bone pain An important gene associated with Dent Disease 1 is CLCN5 (Chloride Voltage-Gated Channel 5), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Hydrochlorothiazide and Antihypertensive Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and cortex, and related phenotypes are aminoaciduria and hematuria

Common Targets
Solute Carrier Family 12 (nonspecified subtype) | CFTR | CLCN5 | OCRL

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