Disease

Ventricular Septal Defect

About the Disease
Ventricular Septal Defect, also known as ventricular septal defects, is related to tetralogy of fallot and heart septal defect. An important gene associated with Ventricular Septal Defect is FOXP4 (Forkhead Box P4), and among its related pathways/superpathways are Human Embryonic Stem Cell Pluripotency and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Salbutamol and Adrenergic Agonists have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and smooth muscle, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
POLR1HASP | GATA4 | NFATC1 | GDF1 | TNFSF11 | FGFR1 | MTRR | PLAGL1 | TCF21 | KDR | NKX2-5 | HAS2 | DSP | HOXA1 | G7422 | JUP | NRP1 | GATA5 | GPC5 | NR2F2 | FIGN | STX18-AS1 | SMAD3 | NKX2-6 | MTR | ABL1 | BCL6 | TWIST1 | HEY2 | SCO2 | FMN1 | BAG3 | POLR1H | HOMEZ | SCN10A

疾病靶点研报
Ventricular Septal Defect

Note: If you'd like to get a target analysis report for Ventricular Septal Defect, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Ventricular Septal Defect at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Neural Tube Defect | Hypersensitivity | Transcobalamin Deficiency | Osteopetrosis | Renal Tubular Dysgenesis | Acrodermatitis Enteropathica | Hemorrhagic Disorders | Brachydactyly | Thrombophilia | Epidermal Nevus Syndrome | Liver Failure | Chylothorax, Congenital | Sclerocornea | Spondylometaphyseal Dysplasia | Jalili Syndrome | Hypersomnia | Fontaine Progeroid Syndrome | X-linked Sideroblastic Anemia | Retinopathy Of Prematurity | Lymphedema | Melnick-Needles Syndrome | Lassa Fever | Dowling-Degos Disease | Orthostatic Intolerance | Gallstones | Apert Syndrome | Retinal Telangiectasia | Myasthenia | Primary Progressive Aphasia | Carpenter Syndrome | Marfan Syndrome | Schnyder Crystalline Corneal Dystrophy | Retinitis Pigmentosa 3 | Agranulocytosis | Necrobiosis Lipoidica | Dysthymia | Fahr Disease | Congenital Nephrotic Syndrome | Maternally Inherited Diabetes And Deafness | Conjunctivitis | Pompe Disease | Hemophagocytic Lymphohistiocytosis | Pneumothorax | Sick Sinus Syndrome 1 | Galloway-Mowat Syndrome | Eccrine Porocarcinoma | Pneumonia, Mycoplasma | Agammaglobulinemia | Nijmegen Breakage Syndrome | Postaxial Polydactyly | Mosaic Variegated Aneuploidy Syndrome 2 | Von Hippel-Lindau Disease | Acanthosis Nigricans | Uveitis, Anterior | Saul-Wilson Syndrome | Nasodigitoacoustic Syndrome | Nail Disorder, Nonsyndromic Congenital | Microtia | Optic Neuritis | Congenital Torticollis | Anodontia | Duane Retraction Syndrome | Kernicterus | Glycogen Storage Disease Type 1 | Aneurysm, Abdominal Aortic | Charcot-Marie-Tooth Disease | Rhabdomyosarcoma | Primary Hyperoxaluria | Astrocytoma | X-linked Acrogigantism | Nanophthalmos | Pure Autonomic Failure | Mucolipidosis Type IV | Congenital Mirror Movements | Spinocerebellar Ataxia Type 23 | Heavy Chain Disease | Reflex Epilepsy | Crohn's Disease | Prurigo Nodularis | Mucormycosis | Carcinoma, Squamous Cell | CEDNIK Syndrome | Cranial Nerve Disease | Hernia, Inguinal | Goiter | Hereditary Coproporphyria | Extramammary Paget's Disease | Intermittent Explosive Disorder | Distal Myopathy 2 | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Non-epidermolytic Palmoplantar Keratoderma | Generalized Epilepsy And Paroxysmal Dyskinesia | Tylosis With Esophageal Cancer | Non-small Cell Lung Cancer | Histiocytic Sarcoma | Spasticity | Schnitzler Syndrome | Alcoholism | Esotropia | Hereditary Spastic Paraplegia | Hyperbilirubinemia, Neonatal | Warsaw Breakage Syndrome | Polycystic Ovary Syndrome | Familial Cerebral Amyloid Angiopathy | Coffin-Siris Syndrome | Primary Progressive Nonfluent Aphasia | Acrocallosal Syndrome | Chudley-McCullough Syndrome | Odonto-onycho-dermal Dysplasia | Frontotemporal Dementia | Paraganglioma | Cat Eye Syndrome | IMAGe Syndrome | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Urofacial Syndrome | Okihiro Syndrome | Glanzmann Thrombasthenia | Preaxial Polydactyly | Pyruvate Decarboxylase Deficiency | Dementia, Vascular | Chorea | Diffuse Palmoplantar Keratoderma | Multiple Sclerosis, Primary Progressive | Krabbe Disease | Focal Cortical Dysplasia Type 2 | Idiopathic Pulmonary Fibrosis | Dermatofibrosarcoma | Myelofibrosis | Acne | Familial Isolated Hyperparathyroidism | Hepatitis, Autoimmune | Supravalvular Aortic Stenosis | Haim-Munk Syndrome | Non-Hodgkin Lymphoma | Cartilage Disorders | Pneumococcal Meningitis | Chronic Kidney Disease | Measles | Exostoses | Stroke | Adenocarcinoma | Epilepsy, Generalized | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Microcephaly | DOCK8 Immunodeficiency Syndrome | Mixed Connective Tissue Disease | Carey-Fineman-Ziter Syndrome | Marinesco-Sjogren Syndrome | Prolymphocytic Leukemia | Twin-to-twin Transfusion Syndrome | Pyruvate Dehydrogenase Deficiency | Androgen Insensitivity | Myeloid Leukemia | Epidermolytic Hyperkeratosis | Cluster Headache | Urolithiasis | Endometrial Hyperplasia | Urethritis | Perry Syndrome | Xeroderma Pigmentosum Variant Type | Pseudohypoparathyroidism Type 1C | Lymphoproliferative Disease, X-linked | Cervical Dystonia | Bietti Crystalline Dystrophy | Central Pain Syndrome | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Familial Hyperaldosteronism | Osteosclerosis | Retinoschisis | Hereditary Mixed Polyposis Syndrome | Aphasia | Ameloblastic Carcinoma | Glomerulonephritis | Hypertelorism | Peeling Skin Syndrome Type B | Myopathy | Pseudoexfoliation Syndrome | Bernard-Soulier Syndrome | Hypermetropia | SAPHO Syndrome | Analgesia | Microcephalic Primordial Dwarfism | Trichotillomania | Alkaptonuria | Cardiomyopathy, Hypertrophic | Microcephaly, Seizures, And Developmental Delay | Placenta Previa | Congenital Dyserythropoietic Anemia | Lattice Corneal Dystrophy | Sarcoidosis | Multicentric Carpotarsal Osteolysis Syndrome | Intermittent Claudication | Dwarfism | Hypogonadism | Brenner Tumor | Papilledema | Hypotrichosis | Arthritis, Gouty | Albinism | Acquired Partial Lipodystrophy | Primrose Syndrome | Vitreoretinopathy, Proliferative | Renal Failure | Antenatal Bartter Syndrome Type 1 | Peyronie's Disease | Proctitis | Anti-glomerular Basement Membrane Disease | Maple Syrup Urine Disease | Metachromatic Leukodystrophy | Erythrokeratodermia Variabilis | Bronchiolitis | Anuria | Craniometaphyseal Dysplasia | Osteopathia Striata With Cranial Sclerosis | Pyruvate Carboxylase Deficiency Disease | Meningococcal Infections | Crouzon Syndrome With Acanthosis Nigricans | Restrictive Dermopathy | Restless Legs Syndrome | Scabies | Early Infantile Epileptic Encephalopathy 1 | Mitochondrial Myopathy | Endometriosis | Angelman Syndrome | KBG Syndrome | Blood Protein Disorders | Familial Hypobetalipoproteinemia | Microphthalmia, Syndromic 7 | Diverticulitis | Shwachman-Bodian-Diamond Syndrome | Meningioma, Benign | Adams-Oliver Syndrome | Cleidocranial Dysplasia | Sertoli Cell-only Syndrome | Hyperinsulinism-hyperammonemia Syndrome | Diabetes Type 1 | Long QT Syndrome Type 3 | Greenberg Dysplasia | Metaphyseal Chondrodysplasia, Schmid Type | Heroin Dependence | Palsy, Cerebral | Liebenberg Syndrome | Diabetes Gestational | Basal Ganglia Disease | Phosphoglycerate Dehydrogenase Deficiency | Myositis | Hepatitis, Chronic | Alazami Syndrome | Erysipelas | Encephalocele | Adenosine Deaminase 2 Deficiency | Spinocerebellar Ataxia Type 14 | Lymphoma Lymphoblastic | Mycosis Fungoides | Usher Syndrome Type III | Acute Motor Axonal Neuropathy | Hepatoblastoma | Cerebrovascular Disorders | Rett Syndrome | Oculodentodigital Dysplasia | Presbyopia | Charcot-Marie-Tooth Disease, Type 2A | Parkinson Disease 6, Autosomal Recessive Early-onset | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Glycogen Storage Disease Type 5 | Leukocyte Adhesion Deficiency Type 1 | Ectrodactyly | Coma | Recurrent Respiratory Papillomatosis | Polymicrogyria | Angiomyolipoma | Plasma Cell Leukemia | Periventricular Leukomalacia | Peeling Skin Syndrome, Acral Type | Pleural Tuberculosis | Tuberculosis | Hereditary Sensory Neuropathy Type 1 | Gynecomastia | Primary Ovarian Insufficiency | Rotor Syndrome | Hemangioblastoma | GNE Myopathy | Lipoma | Thrombocythemia, Essential | Herpes Genitalis | Focal Dermal Hypoplasia | Nemaline Myopathy 10 | Megalencephaly | Sarcoma, Alveolar Soft Part | Cockayne Syndrome | Short-chain Acyl-CoA Dehydrogenase Deficiency | Encephalopathy, Hepatic | Graves Disease | Ocular Hypertension | Coffin-Lowry Syndrome | Tyrosine Hydroxylase Deficiency | Erythropoietic Protoporphyria | Nestor-Guillermo Progeria Syndrome | Blastoma, Pleuropulmonary | Alpha-mannosidosis | Chondrodysplasia Punctata | Neuronal Ceroid Lipofuscinosis | Spinal Cord Diseases | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Prader-Willi Syndrome | Citrullinemia | Tularemia | Hypertension, Pulmonary | Histiocytosis | Ameloblastoma | Obesity | 3-methylglutaconic Aciduria | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Acute Coronary Syndrome | Veno-occlusive Disease | X-linked Creatine Transporter Deficiency | NDH Syndrome | Uterine Leiomyoma | Hemangioma | Primary Carnitine Deficiency | Thanatophoric Dysplasia Type 1 | Dubin-Johnson Syndrome | Paternal Uniparental Disomy Of Chromosome 14 | Primary Hyperoxaluria Type 3 | Colitis, Lymphocytic | Empyema | Myasthenia Gravis | Hypokalemia | Lennox-Gastaut Syndrome | Spinocerebellar Ataxia | Cocaine-Related Disorders | Chromosome 8q21.11 Deletion Syndrome | Camurati-Engelmann Disease | Angioedema, Acquired | Patent Ductus Arteriosus | Cerebral Amyloid Angiopathy | Autism | Spinocerebellar Ataxia Type 20 | Schaaf-Yang Syndrome | Autosomal Recessive Spastic Paraplegia Type 35 | Obesity, Morbid | Osteosarcoma | CDKL5 Deficiency Disorder | Cold-induced Sweating Syndrome | Hereditary Inclusion Body Myopathy | Camptocormia | Spinocerebellar Ataxia Type 16 | Primary Sclerosing Cholangitis | Glycogen Storage Disease Type 1b | Charcot-Marie-Tooth Disease Type 2T | Hyperuricemic Nephropathy, Familial Juvenile | Polydactyly | Acute Tubular Necrosis | Microphthalmia | Superficial Spreading Melanoma | Dyslipidemia | Trichomegaly | Leishmaniasis, Cutaneous | Amyloidosis | Dyslexia | Sporadic Hemiplegic Migraine | Gilbert Syndrome | Tangier Disease | Fraser Syndrome | Chitayat Syndrome | Beckwith-Wiedemann Syndrome | Juvenile Myelomonocytic Leukemia | REM Sleep Behavior Disorder | Graft-versus-host Disease | Pemphigoid | Pemphigus Vulgaris | Hypogammaglobulinemia | Pseudo-pseudohypoparathyroidism | Amyotrophic Lateral Sclerosis, Juvenile | Motion Sickness | Vitamin B12 Deficiency | Common Cold | Combined Malonic And Methylmalonic Acidemia | Imerslund-Grasbeck Syndrome | Stuttering | Isovaleric Acidemia | Fragile X Syndrome | L-2-Hydroxyglutaric Aciduria | Retinitis | Facioscapulohumeral Muscular Dystrophy Type 2 | Adenomatoid Tumor | Charcot-Marie-Tooth Disease, Type 1A | Galactosemia | Non-bullous Congenital Ichthyosiform Erythroderma | Facioscapulohumeral Muscular Dystrophy | Split Hand-foot Malformation | Macular Corneal Dystrophy | Diabetes | Trimethylaminuria | Optic Neuropathy | Myhre Syndrome | Waardenburg Syndrome Type 2E | B-cell Prolymphocytic Leukemia | Galactosialidosis | Syncope