Disease

Ventricular Septal Defect

About the Disease
Ventricular Septal Defect, also known as ventricular septal defects, is related to tetralogy of fallot and heart septal defect. An important gene associated with Ventricular Septal Defect is FOXP4 (Forkhead Box P4), and among its related pathways/superpathways are Human Embryonic Stem Cell Pluripotency and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Salbutamol and Adrenergic Agonists have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and smooth muscle, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
POLR1HASP | GATA4 | NFATC1 | GDF1 | TNFSF11 | FGFR1 | MTRR | PLAGL1 | TCF21 | KDR | NKX2-5 | HAS2 | DSP | HOXA1 | G7422 | JUP | NRP1 | GATA5 | GPC5 | NR2F2 | FIGN | STX18-AS1 | SMAD3 | NKX2-6 | MTR | ABL1 | BCL6 | TWIST1 | HEY2 | SCO2 | FMN1 | BAG3 | POLR1H | HOMEZ | SCN10A

疾病靶点研报
Ventricular Septal Defect

Note: If you'd like to get a target analysis report for Ventricular Septal Defect, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Ventricular Septal Defect at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Basal Ganglia Disease, Biotin-responsive | Coronary Restenosis | Superficial Spreading Melanoma | Currarino Syndrome | Adult Polyglucosan Body Disease | Glycogen Storage Disease Type 4 | Antisocial Personality Disorder | Erythema Multiforme | Chromosome 16p11.2 Deletion Syndrome | Spinocerebellar Ataxia Type 8 | Creutzfeldt-Jakob Disease | Schwannomatosis | Scleritis | Kindler Syndrome | Keratoacanthoma | Urofacial Syndrome | Trichothiodystrophy | Menkes Disease | Asthma | Short-chain Acyl-CoA Dehydrogenase Deficiency | Adams-Oliver Syndrome | Pseudoexfoliation Syndrome | Dyslipidemia | Mumps | Glucagonoma | Pontocerebellar Hypoplasia | Mesothelioma, Malignant | Long QT Syndrome Type 2 | Hereditary Sensory Neuropathy Type 1 | Pontocerebellar Hypoplasia Type 2 | Bone Giant Cell Tumor | Epilepsy | Facioscapulohumeral Muscular Dystrophy | Congenital Tufting Enteropathy | Wolcott-Rallison Syndrome | Heimler Syndrome | Conjunctivitis | Krabbe Disease | Gerodermia Osteodysplastica | Lateral Meningocele Syndrome | Choroiditis | Primary Hyperoxaluria Type 3 | Cryptosporidiosis | Creatine Deficiency Syndrome | Mitochondrial Myopathy | Ependymoma | Lymphedema | Chorea | Neuropathy | Congenital Hypofibrinogenemia | Impetigo | Urea Cycle Disorder | Astigmatism | Nestor-Guillermo Progeria Syndrome | Brachial Plexus Neuropathy | Pontocerebellar Hypoplasia Type 7 | Antenatal Bartter Syndrome Type 1 | Hypogammaglobulinemia | Erythematotelangiectatic Rosacea | Aromatic L-amino Acid Decarboxylase Deficiency | Pyelonephritis | X-linked Myotubular Myopathy | Woodhouse-Sakati Syndrome | Acromesomelic Dysplasia | Amelogenesis Imperfecta | Prolymphocytic Leukemia | Neurodevelopmental Disorders | Sialidosis Type I | Syndactyly | Hypohidrotic Ectodermal Dysplasia, X-linked | Vaginitis | Learning Disability | Chromosome 5q Deletion Syndrome | Encephalitis, Tick-borne | Mandibuloacral Dysplasia With Type A Lipodystrophy | Waardenburg Syndrome | Neonatal Progeroid Syndrome | Osteogenesis Imperfecta Type VI | Non-proliferative Diabetic Retinopathy | Loeys-Dietz Syndrome | Phenylketonuria | Hypolipoproteinemia | Thrombocytopenia | Hamartoma | Diabetes Insipidus, Nephrogenic | Usher Syndrome Type II | Gastroenteritis, Eosinophilic | Ectopia Lentis, Isolated, Autosomal Recessive | Mitochondrial Cytopathy | Spinocerebellar Ataxia Type 28 | Microphthalmia, Syndromic 7 | Cavitary Optic Disc Anomalies | Hennekam Lymphangiectasia-lymphedema Syndrome | Cannabis Abuse | Alpers Syndrome | Cat Eye Syndrome | Crimean-Congo Hemorrhagic Fever | Congenital Dyserythropoietic Anemia Type 1 | Blepharo-cheilo-odontic Syndrome | Succinic Semialdehyde Dehydrogenase Deficiency | Cardiomyopathy, Hypertrophic | Congenital Generalized Lipodystrophy | Galactosialidosis | Progressive Myoclonic Epilepsy | Raine Syndrome | Oculocutaneous Albinism Type 4 | Peyronie's Disease | Dominant Optic Atrophy | Charcot-Marie-Tooth Disease Type 4 | Vasculitis | Alcoholism | Sclerocornea | Hyperostosis | Granular Corneal Dystrophy Type 1 | AIDS Dementia Complex | Pouchitis | Cellulitis | Xeroderma Pigmentosum Variant Type | Ghosal Syndrome | Membranous Nephropathy | Pyruvate Dehydrogenase Deficiency | Hypodontia | Sickle Cell Disease | Asperger Syndrome | Pure Red Cell Aplasia | Double Outlet Right Ventricle | T-cell Lymphoma, Subcutaneous Panniculitis-like | Motor Neuron Diseases | Methylmalonic Acidemia | Androgen Insensitivity | Evans Syndrome | Multiple Epiphyseal Dysplasia | Distal Spinal Muscular Atrophy | HIBCH Deficiency | Persistent Hyperplastic Primary Vitreous | Keratoconus | Lipid Storage Diseases | Leigh Syndrome | Myosin Storage Myopathy | Spitz Nevus | Acne | Osteogenesis Imperfecta Type V | Li-Fraumeni Syndrome | Wagner Disease | Cluster Headache | Gastroenteritis | Gestational Trophoblastic Disease | Distal Myopathy 2 | Blepharospasm | Triple A Syndrome | Potocki-Shaffer Syndrome | Congenital Stromal Corneal Dystrophy | Actinomycetoma | Acute Generalized Exanthematous Pustulosis | Cold-induced Sweating Syndrome | Optic Nerve Hypoplasia, Bilateral | Anuria | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Retinal Vasculitis | Aicardi-Goutieres Syndrome | Hyperkeratosis | Sick Sinus Syndrome | Persistent Mullerian Duct Syndrome | McCune-Albright Syndrome | Preaxial Polydactyly | Hypohidrotic Ectodermal Dysplasia | Bursitis | Dent Disease | Coma | Neurodegeneration With Brain Iron Accumulation | Proteasome-associated Autoinflammatory Syndrome 2 | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Cancer, Colon | Glycogen Storage Disease Type 0, Muscle | Malnutrition | Omenn Syndrome | Kaposiform Hemangioendothelioma | Ameloblastoma | Neutrophilia | Yellow Fever | Familial Thoracic Aortic Aneurysm | Iron Metabolism Disorders | Benign Recurrent Intrahepatic Cholestasis 1 | Absence Epilepsy | Glaucoma | Gigantism | Lathosterolosis | Epidermolysis Bullosa Simplex With Mottled Pigmentation | 3-methylcrotonyl-CoA Carboxylase Deficiency | Cervicitis | Carcinoma, Transitional Cell | Hidradenitis Suppurativa | Parkinsonism | Chudley-McCullough Syndrome | Chronic Idiopathic Myelofibrosis | Personality Disorders | 3C Syndrome | Contact Dermatitis | Hyperinsulinism-hyperammonemia Syndrome | Lissencephaly 2 | Hypophosphatasia | Dementia | Familial Digital Arthropathy-brachydactyly | Hypermetropia | Oligoasthenoteratozoospermia | Eclampsia | Osteoporosis | Nephritis, Interstitial | Myocardial Infarction | Osteopathia Striata With Cranial Sclerosis | Juvenile Myoclonic Epilepsy | Tuberculous Meningitis | Pseudohypoaldosteronism | Osteoglophonic Dysplasia | Congenital Dysfibrinogenemia | Lysosomal Acid Lipase Deficiency | Hypothyroidism | Gnathodiaphyseal Dysplasia | Conn Syndrome | Sialidosis | Familial Isolated Hyperparathyroidism | Osteopetrosis | Ellis-Van Creveld Syndrome | Vascular Calcification | Cold Agglutinin Disease | Hyperphenylalaninemia | Incontinentia Pigmenti | Lichen Planus | Carcinoma, Merkel Cell | Vitreoretinal Degeneration, Snowflake Type | Asthma, Nocturnal | Otitis Externa | Acne Vulgaris | Cerebral Cavernous Malformations | Generalized Epilepsy With Febrile Seizures Plus | Anemia | Stroke, Hemorrhagic | Cataplexy | Cardiomyopathy, Dilated, 1L | Tyrosinemia Type 2 | DICER1 Syndrome | Acute Anterior Uveitis | Encephalopathy | Veno-occlusive Disease | Anorectal Fistula | Encephalitis | Central Pain Syndrome | Paroxysmal Kinesigenic Dyskinesia | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Exfoliative Dermatitis | Poikiloderma With Neutropenia | Acromicric Dysplasia | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Seasonal Mood Disorder | Hereditary Spherocytosis | Autism Spectrum Disorders | Papulopustular Rosacea | Methemoglobinemia Type IV | Congenital Myasthenic Syndrome | Congenital Diaphragmatic Hernia | Gitelman Syndrome | Vitiligo | Lyme Disease | SAPHO Syndrome | Primary Cutaneous Amyloidosis | Hemangioblastoma | Charcot-Marie-Tooth Disease Type 4B1 | Hemophagocytic Lymphohistiocytosis | Histiocytic Sarcoma | Heart Block | Systemic Lupus Erythematosus | Jaundice, Obstructive | Fibromuscular Dysplasia | Hypothalamic Obesity | Charcot-Marie-Tooth Disease, Type 2C | Fowler's Syndrome | Congenital Nephrotic Syndrome | Bullous Pemphigoid | Myofibrillar Myopathy | Epidermolysis Bullosa | Congenital Hereditary Endothelial Dystrophy Type I | Fragile X Syndrome | Mevalonate Kinase Deficiency | Saethre-Chotzen Syndrome | McKusick Type Metaphyseal Chondrodysplasia | Carcinoma In Situ | Asphyxia Neonatorum | Blepharitis | Presbyopia | Pycnodysostosis | Hemimegalencephaly | Cholangiocarcinoma | Primary Progressive Nonfluent Aphasia | Cyclic Vomiting Syndrome | Cancer, Lung | Chondrodysplasia Punctata 2, X-linked Dominant | Diabetes | Transcobalamin Deficiency | Restrictive Dermopathy | Rothmund-Thomson Syndrome | Scoliosis | Chylomicron Retention Disease | Inflammatory Bowel Disease | Xeroderma Pigmentosum | Endocarditis | Blepharoconjunctivitis | Myelodysplasia | Aspergillosis | Osteogenesis Imperfecta Type II | Frontotemporal Dementia | Cohen Syndrome | Cardiac Sarcoidosis | Pseudohypoparathyroidism Type 1A | Proctitis | Pelizaeus-Merzbacher Disease | Uremic Pruritus | Glanzmann Thrombasthenia | NGLY1 Deficiency | Hepatoblastoma | Thrombophlebitis | Traboulsi Syndrome | Combined Malonic And Methylmalonic Acidemia | Primary Sclerosing Cholangitis | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Primary Progressive Aphasia | Meningioma, Benign | Polycystic Kidney, Autosomal Recessive | Tendinitis | Iron Deficiency Anemia | Anti-glomerular Basement Membrane Disease | Cryoglobulinemia | Congenital Myopathy | Idiopathic Multicentric Castleman Disease | Hashimoto Thyroiditis | Amish Infantile Epilepsy Syndrome | REM Sleep Behavior Disorder | Generalized Epilepsy And Paroxysmal Dyskinesia | Fundus Albipunctatus | Familial Hyperaldosteronism | Empyema | Varicocele | Combined Pituitary Hormone Deficiency | Early Infantile Epileptic Encephalopathy 28 | Thymoma, Malignant | Robinow Syndrome | Acute Chest Syndrome | Osteoporosis, Postmenopausal | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Desmosterolosis | Pendred Syndrome | Polydactyly | GATA2 Deficiency | Orotic Aciduria | Gynecomastia | Wolman Disease | Benign Familial Pemphigus | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Brugada Syndrome 1 | Inborn Errors Of Metabolism | Light Chain Amyloidosis | HELLP Syndrome | Sarcoidosis | Salla Disease | Porencephaly | Glioblastoma | Encephalopathy, Ethylmalonic | Fuchs Dystrophy | Sickle Cell Anemia | Spitzoid Melanoma | Hereditary Neuropathy With Liability To Pressure Palsies | Lymphoproliferative Disorders | Acromegaly | Seborrheic Dermatitis | Fukuyama Congenital Muscular Dystrophy | Pulmonary Alveolar Proteinosis | VACTERL/VATER Association | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Sengers Syndrome | Congenital Central Hypoventilation Syndrome | Atopic Dermatitis | Tietze Syndrome | Wolfram Syndrome | Wiskott-Aldrich Syndrome | Marshall-Smith Syndrome | Spinocerebellar Ataxia Type 13 | Hypercholesterolemia | Amebiasis | Renal-hepatic-pancreatic Dysplasia | Primary Torsion Dystonia | Hereditary Elliptocytosis | Bladder Exstrophy | Paronychia | Cousin Syndrome | Adenosine Deaminase 2 Deficiency | Lipoma | Blastoma, Pleuropulmonary | Sclerosing Cholangitis | Leiomyoma | Plasma Cell Leukemia | Angioedema, Hereditary