Mixed Connective Tissue Disease

About the Disease
Mixed Connective Tissue Disease, also known as sharp syndrome, is related to raynaud disease and systemic scleroderma. An important gene associated with Mixed Connective Tissue Disease is SNRNP70 (Small Nuclear Ribonucleoprotein U1 Subunit 70), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Processing of Capped Intron-Containing Pre-mRNA. The drugs Rituximab and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and skin, and related phenotypes are arthritis and gastroesophageal reflux

Common Targets
HLA-B | MRPL39 | HLA-DRB1 | MIR145 | MIR155HG | IL17F | IL10 | MIR146A | CARMN

Note: If you'd like to get a target analysis report for Mixed Connective Tissue Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Mixed Connective Tissue Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Ligneous Conjunctivitis | Neuroma | Multiple Sclerosis, Chronic Progressive | Pantothenate Kinase-associated Neurodegeneration | Aspartylglycosaminuria | Lipid Storage Myopathy | Carbohydrate Metabolism Disorders | Erysipelas | Cannabis Abuse | Panuveitis | Kabuki Syndrome 2 | Tetraplegia | Vulvovaginitis | Spinocerebellar Ataxia Type 27 | HANAC Syndrome | Hyperostosis | Chondrodysplasia Punctata | Primary Biliary Cholangitis | Endometrial Hyperplasia | Chronic Beryllium Disease | Urticaria | Carcinoma, Small Cell | Stargardt Disease | Myotonic Disorders | Bartsocas-Papas Syndrome | Waardenburg Syndrome Type 2A | Spinocerebellar Ataxia Type 12 | Waardenburg Syndrome Type 2E | Pseudohypoparathyroidism Type 1C | Hyperandrogenemia | Neuromyotonia | Hypersensitivity | Localized Scleroderma | Xeroderma Pigmentosum | Prolactinoma | Hemolytic Uremic Syndrome | Hepatorenal Syndrome | Spinocerebellar Ataxia Type 17 | Myosin Storage Myopathy | Sleep Apnea, Obstructive | Cancer, Lung | Eccrine Porocarcinoma | Huntington's Disease-like 2 | Congenital Disorders Of Glycosylation Type II | Leukocyte Adhesion Deficiency Type 1 | Meconium Ileus | Dyggve-Melchior-Clausen Disease | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Polyomavirus Nephropathy | Muir-Torre Syndrome | Inflammatory Myopathy | Megaloblastic Anemia | Periventricular Nodular Heterotopia | Multiple Sulfatase Deficiency | Holoprosencephaly | Fraser Syndrome | Pericarditis | Constipation | Uremia | Cardiac Sarcoidosis | Hennekam Lymphangiectasia-lymphedema Syndrome | Bernard-Soulier Syndrome | Stickler Syndrome | Insulin Resistance | Chylothorax, Congenital | Usher Syndrome | Neovascular Glaucoma | Pseudohypoparathyroidism Type 2 | Sleep Apnea | Chronic Thromboembolic Pulmonary Hypertension | Ependymoma | Hypohidrotic Ectodermal Dysplasia, X-linked | Ataxia-ocular Apraxia 2 | Familial Retinal Arterial Macroaneurysm | X-linked Creatine Transporter Deficiency | Bainbridge-Ropers Syndrome | Behavioral Variant Of Frontotemporal Dementia | Mucormycosis | Brachydactyly | Retinal Vasculitis | Torticollis | Congenital Diaphragmatic Hernia | Bloom Syndrome | Learning Disability | Martsolf Syndrome | Kearns-Sayre Syndrome | Centronuclear Myopathy | Autosomal Recessive Bestrophinopathy | Diamond-Blackfan Anemia | Epidermolysis Bullosa Acquisita | Sensory Neuropathy | Fibronectin Glomerulopathy | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Zygomycosis | Ocular Hypertension | Ophthalmoplegia | Long QT Syndrome Type 3 | Nestor-Guillermo Progeria Syndrome | Treacher Collins Syndrome | Toxic Epidermal Necrolysis | LMNA-related Congenital Muscular Dystrophy | Crigler-Najjar Syndrome | Evans Syndrome | Angina Pectoris | Gerodermia Osteodysplastica | Waardenburg Syndrome Type 2 | Glioma | Persistent Mullerian Duct Syndrome | Hypogammaglobulinemia | Still Disease | Anuria | Pancreatitis, Chronic | Ectrodactyly | Temporal Lobe Epilepsy | Tremor | Histiocytosis | Antenatal Bartter Syndrome Type 1 | Pathological Gambling | Schindler Disease | Anal Fissure | PHARC Syndrome | Spondylolisthesis | Thrombophlebitis | Familial Male-limited Precocious Puberty | Cancer, Prostate | Lateral Meningocele Syndrome | Gardner Syndrome | Hypoglycemia | Biotinidase Deficiency | Takayasu's Arteritis | Chondrodysplasia Punctata 1, X-linked Recessive | Lennox-Gastaut Syndrome | Hereditary Folate Malabsorption | Restless Legs Syndrome | Hemorrhagic Disorders | TARP Syndrome | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Sleep Disorder | Prader-Willi Syndrome | Hyperthermia, Malignant | Chromosome 8q21.11 Deletion Syndrome | Angiodysplasia | Recurrent Respiratory Papillomatosis | Intestinal Obstruction | Metachondromatosis | Behcet's Disease | Chondromyxoid Fibroma | Methylmalonic Aciduria And Homocystinuria, CblC Type | Haim-Munk Syndrome | Axenfeld-Rieger Syndrome | Sick Sinus Syndrome | Schizophrenia | Urofacial Syndrome | Hyperparathyroidism-jaw Tumor Syndrome | Kawasaki Disease | Infantile Refsum Disease | Corticobasal Syndrome | Chondroma | Sickle Cell Disease | Schnyder Crystalline Corneal Dystrophy | Autonomic Nervous System Disorders | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Hamartoma | Osteochondrosis | Leber Hereditary Optic Neuropathy | Leprosy | ICF Syndrome | Thyroiditis, Autoimmune | Von Willebrand Disease | Hyperinsulinemic Hypoglycemia | Cramp Fasciculation Syndrome | Adrenomyeloneuropathy | Pulmonary Veno-occlusive Disease | Hermansky-Pudlak Syndrome | Microphthalmia | Anorexia Nervosa | Dowling-Degos Disease | Acrodysostosis | Giant Cell Arteritis | Renal Tubular Acidosis | Cutaneous Lupus Erythematosus | Alopecia Areata | Spastic Paraplegia Type 7 | Diffuse Palmoplantar Keratoderma | Eosinophilic Asthma | Osteogenesis Imperfecta Type IV | Hypervalinemia | Hypertensive Retinopathy | Veno-occlusive Disease | Tay-Sachs Disease | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Neural Tube Defect | Blomstrand Osteochondrodysplasia | Leishmaniasis, Visceral | Blepharoconjunctivitis | Generalized Epilepsy And Paroxysmal Dyskinesia | Retinal Dystrophy, Early-onset Severe | Hypoalbuminemia | Rett Syndrome | Blood Protein Disorders | Cocaine-Related Disorders | Mixed Connective Tissue Disease | Pearson Syndrome | Seizures | Pneumonia, Viral | Hypohidrotic Ectodermal Dysplasia | Eczema | Lymphangioma | Cholestasis | Mycosis Fungoides | Pemphigus Vulgaris | T-cell Prolymphocytic Leukemia | L-2-Hydroxyglutaric Aciduria | Sweet Syndrome | Early Infantile Epileptic Encephalopathy 1 | Vitelliform Macular Dystrophy | Lymphoma, AIDS-related | Combined Deficiency Of Factor V And Factor VIII | Sarcoma, Ewing | Diabetes Insipidus | Gangliosidosis | Neuroblastoma | Enhanced S-cone Syndrome | Mitochondrial Encephalomyopathy | Reflex Epilepsy | Shock, Cardiogenic | Encephalitis | Meningeal Melanocytoma | Ileitis | Gnathodiaphyseal Dysplasia | Toxoplasmosis | Familial Partial Lipodystrophy | Congenital Nystagmus | Porphyria | Metachromatic Leukodystrophy | Chondrosarcoma | Vaginitis | Osteochondroma | Congenital Poikiloderma | Episodic Ataxia Type 2 | Bardet-Biedl Syndrome | Amish Infantile Epilepsy Syndrome | Pulmonary Alveolar Proteinosis | Adenomyosis | Cantu Syndrome | Familial Thoracic Aortic Aneurysm | Ophthalmia, Sympathetic | Neurofibromatosis Type 1 | Mucolipidosis Type IV | Glucagonoma | Focal Dermal Hypoplasia | Glioblastoma Multiforme | Carcinoma, Signet Ring Cell | Diabetic Macular Edema | Nephrotic Syndrome Type 1 | Nanophthalmos | Osteosarcoma | Glomerulonephritis, Membranoproliferative | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Twin-to-twin Transfusion Syndrome | Keratitis-ichthyosis-deafness Syndrome | Choriocarcinoma | Hereditary Spastic Paraplegia | B-cell Prolymphocytic Leukemia | Glutaric Aciduria Type 2 | Trismus-pseudocamptodactyly Syndrome | Spinal And Bulbar Muscular Atrophy | Atopic Dermatitis | Cardiac Arrest | Multiple Epiphyseal Dysplasia | Brooke-Spiegler Syndrome | Wiedemann-Steiner Syndrome | Pancytopenia | Jawad Syndrome | Japanese Encephalitis | Congenital Stationary Night Blindness | Acute Kidney Injury | Lewy Body Dementia | Hepatitis | DEND Syndrome | Rubinstein-Taybi Syndrome | Sarcoidosis, Pulmonary | Immunoproliferative Disorders | Pontocerebellar Hypoplasia Type 7 | Coma | Cholera | Adenylosuccinate Lyase Deficiency | Filariasis | Epithelial-myoepithelial Carcinoma | Mumps | Oral Lichen Planus | Malnutrition | Oligoastrocytoma | Progressive Familial Intrahepatic Cholestasis | Hemorrhoids | Hepatoblastoma | Lipodystrophy | Pseudohypoparathyroidism Type 1A | CEDNIK Syndrome | Cockayne Syndrome | Apraxia | Glomerulonephritis, Membranous | Hyperparathyroidism, Secondary | Retinal Dystrophy | Compartment Syndrome | T-cell Leukemia | Language Disorders | Scoliosis | Holt-Oram Syndrome | Poirier-Bienvenu Neurodevelopmental Syndrome | Retinal Degeneration | Spinocerebellar Ataxia Type 38 | Spinocerebellar Ataxia Type 28 | Bursitis | Hemosiderosis | Tuberculosis | Chorea-acanthocytosis | Zollinger-Ellison Syndrome | Batten Disease | KBG Syndrome | Pure Autonomic Failure | Macrophagic Myofasciitis | Stuttering | Bipolar Disorder | CDKL5 Deficiency Disorder | Hyperprolactinemia | Focal Segmental Glomerulosclerosis | 3-methylcrotonyl-CoA Carboxylase Deficiency | Mitochondrial Myopathy | Charcot-Marie-Tooth Disease Axonal Type 2N | Inflammatory Joint Disease | Epidermolysis Bullosa Dystrophica | Congenital Hereditary Endothelial Dystrophy Type II | Proctitis | Iron Deficiency Anemia | Polymyalgia Rheumatica | Familial Advanced Sleep Phase Syndrome | Antisocial Personality Disorder | Erythromelalgia | Plasma Cell Leukemia | Metabolic Diseases | Aldosterone Deficiency | Tic Disorder | Pigment Dispersion Syndrome | Shprintzen-Goldberg Syndrome | Plasmacytoma | Spermatocele | Familial Pheochromocytoma-paraganglioma | Aromatic L-amino Acid Decarboxylase Deficiency | Spinocerebellar Ataxia Type 7 | Pulverulent Zonular Cataract | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Mohr-Tranebjaerg Syndrome | Hyperkalemic Periodic Paralysis | Amyloidosis | Patent Ductus Arteriosus | Cutaneous T-cell Lymphoma | Glutaric Aciduria Type 1 | Malaria | Chorioretinitis | Asthma, Nocturnal | Diabetes Gestational | Paget's Disease Of The Breast | Maple Syrup Urine Disease | Anemia | Neurodevelopmental Disorders | Transient Bullous Dermolysis Of The Newborn | Pseudo-pseudohypoparathyroidism | Hypereosinophilic Syndrome | Dengue Hemorrhagic Fever | Cancer, Skin | Optic Neuropathy, Anterior Ischemic | Dysferlinopathy | Idiopathic Multicentric Castleman Disease | Spondylocarpotarsal Synostosis Syndrome | Congenital Bilateral Absence Of Vas Deferens | Cardiomyopathy, Dilated, 1L | Sitosterolemia | Sertoli Cell-only Syndrome | Asplenia | Congenital Stromal Corneal Dystrophy | Blepharophimosis Syndrome | Stiff-man Syndrome | Non-proliferative Diabetic Retinopathy | Chloridorrhea, Congenital | Autism | Facioscapulohumeral Muscular Dystrophy | Carpenter Syndrome | Progressive Osseous Heteroplasia | Lymphoproliferative Disorders | Spinal Muscular Atrophy | Hyperinsulinemia | Varices | Blastomycosis | Retinal Coloboma | Thrombocythemia, Essential | Nephroblastoma | Usher Syndrome Type III | Familial Mediterranean Fever | Periodontitis