Disease

Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency

About the Disease
Long-Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency, also known as lchad deficiency, is related to reye syndrome and hypoglycemia, and has symptoms including myalgia and weakness. An important gene associated with Long-Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency is HADHA (Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Alpha), and among its related pathways/superpathways are Metabolism and Fatty acid metabolism. The drugs Glycerin and (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and retina, and related phenotypes are photophobia and hypoketotic hypoglycemia

Common Targets
HADHA | HADHB | PPARD | UGT1A1

疾病靶点研报
Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency

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