Liver Failure

About the Disease
Infantile Liver Failure Syndrome 1, also known as acute infantile liver failure-multisystemic involvement syndrome, is related to infantile liver failure syndrome and liver failure, infantile, transient, and has symptoms including seizures An important gene associated with Infantile Liver Failure Syndrome 1 is LARS1 (Leucyl-TRNA Synthetase 1), and among its related pathways/superpathways are Regulation of expression of SLITs and ROBOs and tRNA Aminoacylation. The drugs Entecavir and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and brain, and related phenotypes are frontal bossing and sensorineural hearing impairment

Common Targets
PNPLA3 | G842 | IL37 | CFD | IL10 | G367 | CASP8 | ADORA2B | TLR2 | MPV17 | SERAC1 | CD44 | CCN2 | G836 | NF-kappaB (NFkB) | CPT1A | ACAD9 | DLD | Oxysterols receptor LXR (nonspecified subtype) | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | GFM1 | CYP3A5 | KLRK1 | FAH | UGT1A6 | POLG | DGUOK | TFAM | SUCLG1 | G7099 | LARS1 | UGT1A9 | NOX3 | Complement Complex | Transforming growth factor beta (nonspecified subtype) | Caspase (nonspecified subtype) | UGT1A1 | UGT2B15 | NADPH Oxidase Complex | NOTCH2 | KLRC4-KLRK1 | MC4R | SPHK1 | MAPK10 | G3146 | NBAS | NADPH Oxidase (nonspecified subtype) | AIRE | CASP1 | IL18 | CTSB | NPC1 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | CASP6 | G142 | GPBAR1 | G7124 | RRM2B | MAP2K4 | G4233 | EPHX2 | CASP7 | SULT1A1 | BHMT | G1950

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