Spastic Paraplegia Type 7

About the Disease
Spastic Paraplegia 7, Autosomal Recessive, also known as spg7, is related to paraplegia and spasticity, and has symptoms including leg cramps, pain in lower limb and urgency of micturition. An important gene associated with Spastic Paraplegia 7, Autosomal Recessive is SPG7 (SPG7 Matrix AAA Peptidase Subunit, Paraplegin), and among its related pathways/superpathways is Mitochondrial calcium ion transport. The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, eye and brain, and related phenotypes are spastic gait and nystagmus

Common Targets
SPG7

Note: If you'd like to get a target analysis report for Spastic Paraplegia Type 7, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Spastic Paraplegia Type 7 at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Hypolipoproteinemia | Atherosclerosis | Smith-Kingsmore Syndrome | Meleda Disease | Hyperkeratosis | Chordoma | X-linked Acrogigantism | Systemic Lupus Erythematosus | Larsen Syndrome | Open-angle Glaucoma | Borderline Personality Disorder | Nicotine Addiction | Nephrosclerosis | Filariasis | Spinocerebellar Ataxia Type 6 | Vaginitis | Mucolipidosis Type II | Dyggve-Melchior-Clausen Disease | Peripheral Neuropathy | High Molecular Weight Kininogen Deficiency | Myasthenia | Jaundice, Obstructive | Anorexia Nervosa | Kashin-Beck Disease | IMAGe Syndrome | Congenital Afibrinogenemia | Corneal Dystrophies, Hereditary | T-cell Leukemia | Charcot-Marie-Tooth Disease, Type 6 | Waardenburg Syndrome Type 2A | Crisponi Syndrome | Personality Disorders | Progressive Encephalopathy-optic Atrophy Syndrome | Astrocytoma, Anaplastic | Lysosomal Acid Lipase Deficiency | Melnick-Needles Syndrome | Discoid Lupus Erythematosus | Wilson's Disease | Peeling Skin Syndrome, Acral Type | Malnutrition | Sorsby Fundus Dystrophy | Myosin Storage Myopathy | Chronic Myeloid Leukemia | Bipolar Disorder | Cerebellofaciodental Syndrome | Pontocerebellar Hypoplasia Type 2 | Obsessive-compulsive Disorder | Hemangioblastoma | Axenfeld-Rieger Syndrome | Carcinoma, Merkel Cell | Carbohydrate Metabolism Disorders | Best Macular Dystrophy | Congenital Nystagmus | Cancer, Colon | Johanson-Blizzard Syndrome | Pfeiffer Syndrome | Gastroschisis | Cataract | Congenital Hemolytic Anemia | Tyrosine Hydroxylase Deficiency | Liver Failure, Acute Infantile | Alagille Syndrome | McLeod Syndrome | Hepatic Adenomatosis | Amebiasis | Amyotrophic Lateral Sclerosis, Juvenile | Oligospermia | Sarcomatoid Carcinoma Of The Lung | Essential Fructosuria | Pituitary Stalk Interruption Syndrome | Hypoalbuminemia | Waardenburg Syndrome Type 4 | Fibrillation, Atrial | Idiopathic Multicentric Castleman Disease | Epiphyseal Chondrodysplasia, Miura Type | Lactose Intolerance | Pierre Robin Syndrome | Pseudohermaphroditism | Takotsubo Cardiomyopathy | Splenomegaly | Cerebellar Ataxia, Cayman Type | Fetal And Neonatal Alloimmune Thrombocytopenia | Brachydactyly | Chanarin-Dorfman Syndrome | Isobutyryl-CoA Dehydrogenase Deficiency | Melanoma, Uveal | Stroke, Hemorrhagic | Gigantism | Schizophrenia | Osteomalacia | Rhizomelic Chondrodysplasia Punctata | Congenital Stromal Corneal Dystrophy | Hepatic Steatosis | Cartilage Disorders | Cabezas Syndrome | Nance-Horan Syndrome | Glycogen Storage Disease Type 9 | Clouston Hidrotic Ectodermal Dysplasia | Spinocerebellar Ataxia Type 13 | Cutaneous Angiosarcoma | Rotor Syndrome | POEMS Syndrome | Glaucoma, Congenital | Partington Syndrome | Granular Corneal Dystrophy | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Infantile Liver Failure Syndrome 1 | Mosaic Variegated Aneuploidy Syndrome 2 | Triphalangeal Thumb-polysyndactyly Syndrome | Gray Platelet Syndrome | Retinal Diseases | Multiple System Atrophy | Trimethylaminuria | Leukoencephalopathy, Progressive Multifocal | Incontinentia Pigmenti | Oculopharyngeal Muscular Dystrophy | Lymphoma, Mantle Cell | Leri Pleonosteosis | Facioscapulohumeral Muscular Dystrophy | Mevalonate Kinase Deficiency | ADNP Syndrome | Papillon-Lefevre Syndrome | Paraganglioma, Carotid Body | Hepatic Veno-occlusive Disease | Erdheim-Chester Disease | Charcot-Marie-Tooth Disease, Type 2 | Chondrosarcoma | FG Syndrome | Posterior Polar Cataract | Liver Diseases | CHOPS Syndrome | Lymphomatoid Granulomatosis | Arterial Tortuosity Syndrome | Ehlers-Danlos Syndrome | Keratoacanthoma | Ataxia-ocular Apraxia 2 | Ischemia | Neurofibromatosis | Aplastic Anemia | Hepatitis B, Chronic | Hereditary Pyropoikilocytosis | Antisocial Personality Disorder | Walker-Warburg Syndrome | Spinocerebellar Ataxia Type 8 | Hypohidrotic Ectodermal Dysplasia | Epidermal Nevus Syndrome | Carpenter Syndrome | Myoclonus-dystonia Syndrome | Adams-Oliver Syndrome | Sotos Syndrome | Pleural Tuberculosis | Kearns-Sayre Syndrome | Whipple's Disease | Neuroblastoma | Dental Caries | Feingold Syndrome | Neural Tube Defect | Hepatitis, Chronic | Pemphigus | Contact Dermatitis | Otopalatodigital Syndrome Type 2 | 3-methylglutaconic Aciduria Type I | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Rubinstein-Taybi Syndrome | Osteochondroma | Long QT Syndrome Type 2 | Blepharitis | Cancer, Prostate | Chondroma | Multiple Sclerosis, Chronic Progressive | Panniculitis | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Neonatal Progeroid Syndrome | Hyperandrogenemia | Cohen Syndrome | Multiple Sclerosis, Secondary Progressive | Lyme Disease | Hydrops Fetalis | Kabuki Syndrome 2 | Autosomal Recessive Spastic Paraplegia Type 35 | Congenital Muscular Dystrophy | Empyema | Anencephaly | Protein C Deficiency | Double Outlet Right Ventricle | Esophageal Carcinoma | Anosmia, Congenital | Olmsted Syndrome | Hypoparathyroidism | Combined Pituitary Hormone Deficiency | Sick Sinus Syndrome | Cocaine-Related Disorders | Pulmonary Vein Stenosis | Warsaw Breakage Syndrome | Proteus Syndrome | Myopia | Charcot-Marie-Tooth Disease, Type 1A | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Iron Metabolism Disorders | Astrocytoma | Milk Allergy | Thromboembolism | Galactosialidosis | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Alazami Syndrome | Communication Disorders | Paget's Disease Of The Breast | Thymoma, Malignant | Basal Cell Nevus Syndrome | Tylosis With Esophageal Cancer | Thyroiditis, Autoimmune | Otitis Media | Exocrine Pancreatic Insufficiency | DNA Ligase IV Deficiency | Aneurysm, Thoracic Aortic | Lymphoma | Loeys-Dietz Syndrome | COACH Syndrome | Congenital Myopathy | Ganglioneuroma | Glutaric Aciduria Type 2 | Renal Tubular Dysgenesis | Angiosarcoma Of The Breast | Saul-Wilson Syndrome | Opisthorchiasis | 3-M Syndrome | Hypoglycemia | Nanophthalmos | Familial Digital Arthropathy-brachydactyly | Schuurs-Hoeijmakers Syndrome | Marshall-Smith Syndrome | Osteopathia Striata With Cranial Sclerosis | Treacher Collins Syndrome | Cold-induced Sweating Syndrome | Neuromuscular Disorders | Congenital Tufting Enteropathy | Dowling-Degos Disease | Spinocerebellar Ataxia Type 3 | Hyperbilirubinemia, Neonatal | Congenital Adrenal Hyperplasia | Carcinoid Tumor | Hereditary Coproporphyria | Hemochromatosis Type 1 | Peeling Skin Syndrome Type B | Urolithiasis | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Cherubism | Avellino Corneal Dystrophy | Leber Congenital Amaurosis | Schizoaffective Disorder | Venous Insufficiency | Familial Pheochromocytoma-paraganglioma | Pseudohypoparathyroidism Type 2 | Papilloma | Urea Cycle Disorder | Lymphangiomatosis | Menetrier Disease | Fuchs Heterochromic Iridocyclitis | Schindler Disease | Creatine Deficiency Syndrome Due To AGAT Deficiency | Peripheral T-cell Lymphoma | SAPHO Syndrome | Cholelithiasis | Acromicric Dysplasia | Histiocytic Sarcoma | Epidermolysis Bullosa Dystrophica | Spinocerebellar Ataxia Type 2 | Zellweger Syndrome | Lymphangioleiomyomatosis | Hepatoblastoma | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Behavioral Variant Of Frontotemporal Dementia | Arthritis, Gouty | Primary Familial Brain Calcification | Scapuloperoneal Myopathy, X-linked Dominant | Hyperacusis | Poirier-Bienvenu Neurodevelopmental Syndrome | Polycythemia | Agranulocytosis | Deafness, Dystonia, And Cerebral Hypomyelination | Myofibromatosis | Gardner Syndrome | Bronchitis | McCune-Albright Syndrome | Neurogenic Bladder | Macrodactyly | HELLP Syndrome | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Peritonitis | B-cell Chronic Lymphocytic Leukemia | Sarcoma, Ewing | Hypertelorism | Potocki-Shaffer Syndrome | Kaposi Sarcoma | Barrett Esophagus | Unverricht-Lundborg Syndrome | Renal Hypomagnesemia 3 | Glycogen Storage Disease Type 1b | Cardiomyopathy, Restrictive | Onchocerciasis | Camurati-Engelmann Disease | Congenital Stationary Night Blindness | Proximal Symphalangism | Renpenning Syndrome | Kallmann Syndrome | Agnathia-Otocephaly Complex | Pseudohypoaldosteronism | Castleman Disease | Prolidase Deficiency | Reticular Dysgenesis | Li-Fraumeni Syndrome | Cataplexy | Primary Progressive Nonfluent Aphasia | Colon Adenoma | Spinal Muscular Atrophy Type 3 | Colitis, Lymphocytic | Congenital Hypofibrinogenemia | Enhanced S-cone Syndrome | Cholestasis | Inflammatory Joint Disease | AIDS | Giant Cell Glioblastoma | Cryptorchidism | Wiskott-Aldrich Syndrome | Aspartylglycosaminuria | Occipital Neuralgia | Guanidinoacetate Methyltransferase Deficiency | Sjogren Syndrome | Primary Lateral Sclerosis | GATA2 Deficiency | Juvenile Hyaline Fibromatosis | Congenital Disorders Of Glycosylation Type II | Lung Diseases | Hepatitis C, Chronic | Demyelinating Diseases | Genitopatellar Syndrome | Dwarfism | Sensorineural Hearing Loss | Asplenia | Retinal Vasculitis | Leukocyte Adhesion Deficiency Type 1 | Cold Agglutinin Disease | Pigment Dispersion Syndrome | Vitamin K Deficiency | Porphyria, Acute Intermittent | Hypotrichosis | Osteoporosis, Postmenopausal | Cholangitis | Meningioma | Sertoli Cell-only Syndrome | Colitis | Panic Disorder | Hypoplastic Left Heart Syndrome | Hydrolethalus Syndrome | Ligneous Conjunctivitis | Hypoproteinemia, Hypercatabolic | Myotonic Disorders | Macular Corneal Dystrophy | Japanese Encephalitis | Gastroenteritis | Osteogenesis Imperfecta Type II | Heroin Dependence | Usher Syndrome Type II | Blepharoconjunctivitis | Dysgerminoma | Ventricular Septal Defect | Dent Disease | Superficial Spreading Melanoma | T-cell Chronic Lymphocytic Leukemia | Schizencephaly | Transcobalamin Deficiency | Klippel-Feil Syndrome | Hyperprolactinemia | Polyradiculopathy | Lymphoproliferative Disorders | Oculocutaneous Albinism Type 2 | Multiple Sclerosis | Pancreatitis, Chronic | Dupuytren Disease | Sleep Apnea | Adenoma, Pleomorphic | Fascioliasis | Aicardi-Goutieres Syndrome | Scleroderma, Diffuse | Nephropathy | Lathosterolosis | Dystonia Musculorum Deformans | Pyruvate Carboxylase Deficiency Disease | Atrioventricular Septal Defect | Familial Hyperaldosteronism | Acute Coronary Syndrome | Ectopia Lentis, Isolated, Autosomal Recessive | Malaria, Cerebral | Leri-Weill Dyschondrosteosis | Long QT Syndrome Type 3 | Adenoma, Villous | GLUT1 Deficiency Syndrome | Acrocallosal Syndrome | Otitis Externa