Spinocerebellar Ataxia Type 6

About the Disease
Spinocerebellar Ataxia 6, also known as spinocerebellar ataxia type 6, is related to spinocerebellar ataxia 1 and spinocerebellar ataxia 2, and has symptoms including cerebellar ataxia An important gene associated with Spinocerebellar Ataxia 6 is CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A), and among its related pathways/superpathways are ERK Signaling and MIF Mediated Glucocorticoid Regulation. The drugs Glutamic acid and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cerebellum and eye, and related phenotypes are gait ataxia and unsteady gait

Common Targets
SLC1A3 | KCND3 | HDAC1 | Voltage-Gated Sodium Channel Complex | HDAC3 | Glutamate Transporter (nonspecified subtype) | Sodium channel (nonspecified subtype) | CACNA1A | HDAC2

Note: If you'd like to get a target analysis report for Spinocerebellar Ataxia Type 6, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Spinocerebellar Ataxia Type 6 at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Exocrine Pancreatic Insufficiency | Neutrophilia | Sick Sinus Syndrome 1 | Atrioventricular Septal Defect | Hereditary Sensory And Autonomic Neuropathy | Ectodermal Dysplasia | Neurodegeneration With Brain Iron Accumulation | Familial Partial Lipodystrophy | Hypoalbuminemia | Left Ventricular Noncompaction | Acrocallosal Syndrome | WAGR Syndrome | Conjunctivitis | Geleophysic Dysplasia | Porphyria Cutanea Tarda | Congenital Aniridia | Mabry Syndrome | Otopalatodigital Syndrome Type 2 | Early Infantile Epileptic Encephalopathy 4 | Spinocerebellar Ataxia | KBG Syndrome | Myopia | Adrenal Insufficiency | Speech Disorders | Compartment Syndrome | Takayasu's Arteritis | Polyneuropathy | Cluster Headache | Farber Disease | Neurocysticercosis | Distal Spinal Muscular Atrophy | Sarcoma, Alveolar Soft Part | Familial Thoracic Aortic Aneurysm | Sertoli Cell-only Syndrome | Keloid | Primary Progressive Aphasia | Chorea | Wagner Disease | Histiocytosis | Iron Overload | Leishmaniasis, Visceral | Sarcomatoid Carcinoma Of The Lung | Kernicterus | Wolman Disease | Cancer, Skin | Tyrosine Hydroxylase Deficiency | Leukocyte Adhesion Deficiency Type 1 | Thrombocytopenia | Epidermolysis Bullosa Simplex, Generalized | Diabetes Insipidus | N-acetylglutamate Synthase Deficiency | Cholestasis | Porencephaly | Alcoholism | Non-proliferative Diabetic Retinopathy | Hernia, Inguinal | Poirier-Bienvenu Neurodevelopmental Syndrome | Rhizomelic Chondrodysplasia Punctata | Ulcerative Colitis | Primary Aldosteronism | Cantu Syndrome | Erythematotelangiectatic Rosacea | LEOPARD Syndrome | Progressive External Ophthalmoplegia | Ocular Hypertension | Nail-Patella Syndrome | Microcephaly | Keratosis | Diabetes | Multicentric Carpotarsal Osteolysis Syndrome | Sturge-Weber Syndrome | Spinal Muscular Atrophy | Hyperinsulinemic Hypoglycemia | Coenzyme Q10 Deficiency | Tyrosinemia | Inflammatory Bowel Disease | Camptocormia | Hereditary Coproporphyria | Angelman Syndrome | Autosomal Recessive Spastic Paraplegia Type 35 | Orotic Aciduria | Pearson Syndrome | Occipital Neuralgia | Pure Autonomic Failure | Blomstrand Osteochondrodysplasia | Postaxial Polydactyly | Mountain Sickness | Metachondromatosis | Cannabis Abuse | Chronic Neutrophilic Leukemia | Analgesia | Optic Neuropathy, Anterior Ischemic | Uveitis, Anterior | Japanese Encephalitis | Neural Tube Defect | Central Pain Syndrome | Zollinger-Ellison Syndrome | Esotropia | Otitis Media | Osteoarthritis | Diabetes Insipidus, Nephrogenic | Premature Ejaculation | Anxiety Disorders | Crigler-Najjar Syndrome | Ornithine Transcarbamylase Deficiency | Familial Hemiplegic Migraine | Metatropic Dysplasia | Osteoporosis, Postmenopausal | Sengers Syndrome | Glaucoma | Pituitary Stalk Interruption Syndrome | Conjunctivitis, Allergic | Hypertensive Nephropathy | Congenital Diaphragmatic Hernia | Low Phospholipid Associated Cholelithiasis | Carcinoma, Squamous Cell | Macular Degeneration | Glaucomatocyclitic Crisis | Retinitis | Thyroiditis, Autoimmune | Enlarged Vestibular Aqueduct | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Erythropoietic Protoporphyria | Esthesioneuroblastoma | Benign Hereditary Chorea | 3-methylglutaconic Aciduria Type IV | Acute Leukemia | Diffuse Mesangial Sclerosis | Astrocytoma, Anaplastic | Congenital Bilateral Absence Of Vas Deferens | Chudley-McCullough Syndrome | Spastic Paraplegia Type 7 | Isobutyryl-CoA Dehydrogenase Deficiency | Mitochondrial Encephalomyopathy | DNA Ligase IV Deficiency | Canavan Disease | Pathological Gambling | Cystinosis | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Limb Girdle Muscular Dystrophy | Cushing Syndrome | Larsen Syndrome | Chronic Myelomonocytic Leukemia | Pityriasis Rubra Pilaris | Postpartum Depression | Basal Ganglia Disease, Biotin-responsive | Rothmund-Thomson Syndrome | Nemaline Myopathy 8 | H Syndrome | Hereditary Folate Malabsorption | Congenital Myopathy | Neurofibroma, Plexiform | Hoyeraal-Hreidarsson Syndrome | Porphyria, Variegate | Pheochromocytoma | Aplastic Anemia | Schuurs-Hoeijmakers Syndrome | Swine Influenza | Micro Syndrome | Vitamin K Deficiency | Hydrocephalus, Normal Pressure | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Lichen Sclerosus | Prader-Willi Syndrome | Paraplegia | Conduct Disorder | Skin Papilloma | Barakat Syndrome | Noonan Syndrome | Pneumonia, Bacterial | Meckel-Gruber Syndrome | Holoprosencephaly | Cold-induced Sweating Syndrome | Neurodevelopmental Disorders | Adenylosuccinate Lyase Deficiency | Corneal Edema | Anovulation | Craniosynostosis | Angiomyolipoma | Pancreatitis | IMAGe Syndrome | Centronuclear Myopathy | Pineoblastoma | Connective Tissue Disorders | Blau Syndrome | Fibronectin Glomerulopathy | Usher Syndrome | Ameloblastic Carcinoma | Waardenburg Syndrome Type 1 | McCune-Albright Syndrome | Myoclonic Epilepsy With Ragged Red Fibers | Spinocerebellar Ataxia Type 21 | Hypodontia | Cancer, Prostate | Neurofibroma | Eczema | Keratoconus | Ganglioneuroma | Oguchi Disease-2 | Multiple Epiphyseal Dysplasia | Mitochondrial Myopathy | Von Willebrand Disease | Adenomatoid Tumor | Maple Syrup Urine Disease | Cramp Fasciculation Syndrome | Erdheim-Chester Disease | Rheumatic Heart Disease | Aldosterone Synthase Deficiency | Autosomal Recessive Bestrophinopathy | Amenorrhea | Keratosis, Actinic | Optic Neuritis | Ophthalmia, Sympathetic | Neurofibrosarcoma | Cataract | Primary Torsion Dystonia | Glycogen Storage Disease Type 1b | Retinal Detachment | Stickler Syndrome | Hepatitis A | Homocystinuria | Progressive Familial Intrahepatic Cholestasis Type 2 | Nephrosclerosis | Meningioma | Encephalopathy, Ethylmalonic | Parkinson Disease 6, Autosomal Recessive Early-onset | Graves Disease | Cryopyrin-associated Periodic Syndromes | Acute Generalized Exanthematous Pustulosis | Sialidosis Type I | Neuromyotonia | Chitayat Syndrome | Overactive Bladder | Fowler's Syndrome | Progressive Familial Intrahepatic Cholestasis | Panuveitis | Birk-Barel Syndrome | Costello Syndrome | Hyperbilirubinemia, Neonatal | Liver Failure | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Coronary Artery Disease | Hypertriglyceridemia | Monilethrix | Giant Cell Glioblastoma | Burn-McKeown Syndrome | Seborrheic Dermatitis | Amish Infantile Epilepsy Syndrome | Traboulsi Syndrome | Stomatitis | Congenital Fiber-type Disproportion Myopathy | Ichthyosis Bullosa Of Siemens | Congenital Poikiloderma | Amyotrophic Lateral Sclerosis, Juvenile | Paraganglioma | Neurodermatitis | Leukemia | Sarcosinemia | Cone Dystrophy | Dysthymia | Polycystic Ovary Syndrome | Cohen Syndrome | Gangliosidosis | GM2-gangliosidosis AB Variant | Rhabdomyosarcoma | Vasculitis | Pulverulent Zonular Cataract | Fanconi Syndrome | Kearns-Sayre Syndrome | Marinesco-Sjogren Syndrome | Neuroendocrine Cancer | GLUT1 Deficiency Syndrome | Epidermolytic Palmoplantar Keratoderma | ADNP Syndrome | Fibrosarcoma | Amebiasis | Hyperparathyroidism | Lymphopenia | Niemann-Pick Disease, Type B | Pancytopenia | Lymphangioma | Short-chain Acyl-CoA Dehydrogenase Deficiency | Jaundice, Obstructive | Inflammatory Joint Disease | Oral Lichen Planus | Microphthalmia | Blue Rubber Bleb Nevus Syndrome | Chondroma | Glycogen Storage Disease Type 1 | Cholelithiasis | Exotropia | Prurigo Nodularis | Hypoglycemia | Neuroectodermal Tumors, Primitive | Hypoproteinemia, Hypercatabolic | Lipid Metabolism Disorders | Pelvic Inflammatory Disease | Lewy Body Dementia | Primary Cutaneous Amyloidosis | Mitochondrial Cytopathy | Hypotonia-cystinuria Syndrome | Cutaneous T-cell Lymphoma | Acne | Hyperkeratosis | Muscle Wasting | Hemosiderosis | Congenital Nystagmus | Duodenal Atresia | Facioscapulohumeral Muscular Dystrophy | Temtamy Preaxial Brachydactyly Syndrome | Neurofibromatosis Type 2 | Paraganglioma, Carotid Body | Hepatorenal Syndrome | Apert Syndrome | Gastric Atrophy | Blepharophimosis Syndrome | Familial Episodic Pain Syndrome | Basal Ganglia Cerebrovascular Disease | Proopiomelanocortin Deficiency | Follicular Dendritic Cell Sarcoma | Atherosclerosis | Lymphoma, Mantle Cell | Spondyloepiphyseal Dysplasia Tarda, X-linked | Small Lymphocytic Lymphoma | Lymphomatoid Granulomatosis | Autosomal Recessive Congenital Ichthyosis | Delayed Sleep Phase Syndrome | Arthritis, Gouty | Chromosome 8q21.11 Deletion Syndrome | Smith-Lemli-Opitz Syndrome | Infantile Neuroaxonal Dystrophy | Reticular Dysgenesis | Facioscapulohumeral Muscular Dystrophy Type 1 | Plasmacytoma | Pierson Syndrome | Camurati-Engelmann Disease | Trismus-pseudocamptodactyly Syndrome | Desbuquois Syndrome | B-cell Chronic Lymphocytic Leukemia | Duchenne Muscular Dystrophy | Systemic Lupus Erythematosus | Asplenia | Behavioral Variant Of Frontotemporal Dementia | Hypertrophy | Congenital Generalized Lipodystrophy | Atopy | Agoraphobia | Primary Erythromelalgia | Trigonocephaly | Hepatitis E | Lipoma | Osteonecrosis | Cleidocranial Dysplasia | Hidradenitis Suppurativa | Cholera | Rickets | Mucormycosis | GATA2 Deficiency | Kleine-Levin Syndrome | Charcot-Marie-Tooth Disease Type 3 | Adenoma, Pituitary | Bursitis | Bladder Exstrophy | Donnai-Barrow Syndrome | Leukoplakia, Oral | Hemolytic Anemia | Reye Syndrome | Posterior Polar Cataract | Retinal Dystrophy | Dominant Optic Atrophy | Onchocerciasis | Depression | Familial Exudative Vitreoretinopathy | Synpolydactyly | Hydrocephalus | Van Der Knaap Disease | Corticobasal Syndrome | Hereditary Spherocytosis | Psoriasis | Methemoglobinemia Type IV | Anterior Segment Dysgenesis | Aneurysm, Thoracic Aortic | Anodontia | Smith-Kingsmore Syndrome | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Anorectal Malformations | Roberts Syndrome | Autoimmune Hemolytic Anemia | Diffuse Palmoplantar Keratoderma | Glutathione Synthetase Deficiency | Osteochondroma | Neuronal Ceroid Lipofuscinosis | Autoimmune Polyendocrine Syndrome | Hyperlipidemia, Familial Combined | Mevalonate Kinase Deficiency | Infectious Diarrhea | Aromatic L-amino Acid Decarboxylase Deficiency | Localized Scleroderma | Pseudohypoparathyroidism Type 1B | Myeloid Leukemia