Leukemia

About the Disease
Leukemia, also known as leukaemia, unspecified, without mention of remission, is related to myeloid leukemia and leukemia, chronic myeloid, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia is MIR27A (MicroRNA 27a), and among its related pathways/superpathways are NF-kappaB Signaling and Imatinib and chronic myeloid leukemia. The drugs Azacitidine and Decitabine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and t cells, and related phenotypes are Increased HDAC inhibitor resistance and endocrine/exocrine gland

Common Targets
PIK3CG | KDR | HLA-DRB9 | XRCC1 | YES1 | KIR3DL2 | G6714 | SIRT2 | BRD7 | HCK | PVT1 | DNA Methyltransferase (DNMT) (nonspecified subtype) | CEBPE | CYBA | AURKA | TEC | NT5C2 | G472 | APIP | DNA-Directed DNA Polymerase Complex | KCNH2 | ABL1 | G1956 | FGR | Cyclin B (nonspecified subtype) | JAK2 | NBN | G3576 | Sphingosine kinase (nonspecified subtype) | G3845 | WDR5 | CASP7 | RUNX2 | CDK4/Cyclin D1 | Protein farnesyltransferase | SNCA | PSMB5 | IL1B | DPYD | Integrin alpha4beta1 (VLA-4) receptor | MALT1 | Protein Phosphatase 2A | HLA-E | IL-15 receptor | ASNS | PRMT6 | PTPN7 | IL12B | ALDH1A2 | Protein arginine N-methyltransferase (nonspecified subtype) | G3569 | G6774 | CDK2 | gamma-Secretase | G7015 | CD6 | ASXL1 | CA5A | CSK | TFRC | G1026 | Tyrosine-Protein Kinases Src (nonspecified subtype) | Serine/Threonine Kinase (nonspecified subtype) | MKNK2 | BTK | HDAC6 | PRMT8 | HDAC2 | Tachykinin Receptor (nonspecified subtype) | Cyclophilins (nonspecified subtype) | HDAC8 | SMO | LILRB4 | CCNH | G3620 | CD1A | Heat shock protein 90 (nonspecified subtype) | AMP-activated protein kinase (AMPK) | RARA | CDK5/p25 | IFNL3 | IFI44L | HOXA9 | Inhibitor of Apoptosis Proteins (IAPs) (nonspecified subtype) | GATA1 | G595 | HOXB13 | RAC2 | VSTM1 | Interferon-gamma Receptor | MLL1/MLL Complex | Thioredoxin-disulfide reductase (TrxR) (nonspecified subtype) | G1/S-specific cyclin-E (nonspecified subtype) | TSPAN33 | OPRM1 | CHEK1 | NPM1 | NRAS | CDK6 | TRAC | ROCK1 | IL2RA | SLC7A5 | GP1BA | PRKCA | Protein Kinase B (PKB/Akt) (nonspecified subtype) | Folate Receptor (nonspecified subtype) | NF-kappaB (NFkB) | DGAT2 | AURKB | AXL | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | CA1 | Hedgehog Protein (nonspecified subtype) | Ephrin Receptor (nonspecified subtype) | AK2 | CCR4 | BMX | LCK | Protein kinase C (nonspecified subtype) | G598 | CD3 Complex (T Cell Receptor Complex) | ETV6 | Casein kinase I (nonspecified subtype) | TYK2 | G5133 | HLA class II histocompatibility antigen DR (HLA-DR) | CSF1R | LOC102724428 | BRD2 | PPARA | JMJD1C | CORO1A | KIT | G1950 | TET3 | SLC39A7 | G842 | CEBPA | Phospholipase C (nonspecified subtype) | PIM3 | ALDH2 | XRCC6 | CDK4 | CDK5 | IKZF1 | TNFSF13B | mTOR complex 1 | G29126 | Integrin Receptor (nonspecified subtype) | IL3RA | DHODH | HLA-G | TFIP11 | CSF3R | DCK | TOP1 | G4780 | CD2 | HSF1 | CDK9/Cyclin T1 | G7852 | MKNK1 | MAP3K14 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | ADAM17 | TNFSF11 | DDR2 | PIK3CB | ESR2 | BCR | MAP2K1 | FCRL1 | CYP1A1 | BRD4 | ASH1L | HLA-DRB1 | IL-2 receptor | NCF4 | PIK3CD | XIAP | DNA Topoisomerase II (nonspecified subtype) | Adenylate Cyclase (nonspecified subtype) | FGFR3 | G23411 | PIP4K2B | CDK9 | Adenosine deaminase (nonspecified subtype) | IMPDH1 | LGALS9 | ARID5B | UBE2K | G673 | ADA | HDAC3 | CCN2 | CD52 | CD44 | FCRL3 | BCHE | Integrin alpha5beta1 (VLA-5) receptor | DYRK1A | CD38 | CD40 | LAIR1 | XPO1 | CD22 | PRMT1 | PYGL | G5595 | CLEC12A | Histone acetyltransferase (HAT) (nonspecified subtype) | SYK | PDGFRB | G142 | ITK | NCK1 | KDM2A | SETBP1 | HLA-DRA | KLRK1 | PPARD | CEACAM8 | Interleukin-12 (IL-12) | MAP4K4 | FOXA1 | MSLN | HDAC1 | G581 | CCNT1 | G4170 | LILRB3 | Tyrosine Kinase (nonspecified subtype) | Reverse transcriptase (Telomerase) | FCGR3A | EPHA3 | DDX41 | MUC1 | G4609 | TET1 | S100A8 | PTCH1 | STAT5 (nonspecified subtype) | IMPDH2 | PRKCD | PPARG | IL-6 receptor | ALDH1A1 | PRF1 | PTPN1 | CASP8 | FCRL2 | HLA-A | G920 | ACHE | GSK3B | TSPO | G9429 | Heme Oxygenase (HO) (nonspecified subtype) | MS4A1 | MEN1 | G2475 | LYPLA1 | Interferon alpha/beta Receptor (nonspecified subtype) | CD7 | CD70 | DNA-Directed RNA Polymerase II | CDK1/Cyclin B | XRCC3 | MME | PNP | MERTK | Retinoid acid receptor (nonspecified subtype) | IRF5 | ZFPM2 | AURKC | CXXC4 | TRBV3-1 | G3480 | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | FLT4 | EPHB6 | CCND3 | CCR9 | FBXL19 | Vacuolar H+ ATPase | LRP1 | BPTF | KDM2B | CD33 | JOSD1 | FOLH1 | Glycylpeptide N-tetradecanoyltransferase (nonspecified subtype) | TNFRSF11A | Elastase (nonspecified subtype) | NR1H4 | KIF11 | PDE6D | PIK3C3 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | KMT2A | HDAC4 | IDH2 | Integrin alphaLbeta2 (LFA-1) receptor | CUX1 | G2033 | BRPF1 | IL1RAP | MLL/SET1 Complex | KDM1A | Mitogen-Activated Protein Kinase (nonspecified subtype) | G2099 | FRK | FLT1 | G836 | PGAM1 | ADP/ATP Translocase (nonspecified subtype) | alpha-beta T Cell Receptor Complex (TCR) | Caspase (nonspecified subtype) | TEX48 | CD3E | G7157 | TYRO3 | CDK2/Cyclin A | KLRG1 | HLA-DRB3 | BLK | SPI1 | ROR1 | KLRC4-KLRK1 | LYPLA2 | TNFRSF13C | G4318 | CCNE1 | BCL2L2 | TNFRSF17 | Heat shock protein 70 (nonspecified subtype) | PROM1 | gamma-delta T Cell Receptor (TCR) Complex | TDO2 | SIK2 | PPFIA1 | MLLT1 | UCHL1 | DOT1L | USP30 | DDR1 | FPGS | SMN1 | TPCN2 | PIM1 | Poly [ADP-ribose] polymerase (nonspecified subtype) | ERN1 | IL1A | G4193 | IL16 | PLA2R1 | IL12A | BRD3 | VCP | VPREB1 | XRCC4 | CA2 | CDK8 | IL2 | POLA1 | NAPRT | MYB | ABHD17B | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) (nonspecified subtype) | SRSF2 | CXCR2 | Tubulin | TMEFF1 | LYN | FCAR | CDK2/Cyclin E | TTLL5 | METAP2 | Aurora Kinase (nonspecified subtype) | TIGIT | GAA | OTUB1 | MAP2K2 | CA5B | PRKCQ | DHX33 | SIK1 | SPN | G1786 | CALR | G6776 | PALB2 | RUNX1 | TLR9 | CD79B | Cyclin A (nonspecified subtype) | CDK7/Cyclin H | SMN2 | CASP1 | G5743 | CTLA4 | VDR | NAMPT | WT1 | TNFRSF8 | G4233 | PIK3CA | TYMS | PIP4K2A | CD47 | HLA-DRB5 | GGH | G7124 | CD37 | G2064 | ULBP1 | alpha-Amylase (nonspecified subtype) | ALB | FLT3 | ABCC1 | FYN | BIRC5 | PTPN11 | STING1 | PDGFRA | HLA-DRB6 | PRMT3 | ANPEP | PTPRC | BRD9 | MTHFR | HLA-DRB7 | DHFR | LTA4H | Proteasome Complex | VHL | G2146 | MGMT | ALDH1A3 | ARID1A | TAOK2 | Histone deacetylase (nonspecified subtype) | TOP2A | TXK | FCRL5 | G5243 | CD5 | PPARGC1A | MTR | ENOX2 | ALOX5 | CDK1 | IFNAR2 | SIK3 | LINC00467 | CD19 | Glutathione peroxidase (nonspecified subtype) | U2AF1 | RNASEL | TRBC2 | HLA-DRB8 | PI3 | CDK7 | DUSP1 | ASRGL1 | JAK3 | G238 | IL13 | PIM2 | JAK1 | PRAME | GSTP1 | G596 | TRBC1 | HMOX1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | G5347 | CHEK2 | TGFBI | TNFRSF10B | CDK4/Cyclin D3 | CRBN

Note: If you'd like to get a target analysis report for Leukemia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Leukemia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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